Oral candidiasis established in the sialoadenectomised rat

Jorge, Antônio Olavo Cardoso; Totti, Marilda Aparecida Gonçalves; Almeida, OP; Scully, Crispian

doi:10.1111/j.1600-0714.1993.tb00042.x

Cited by 26 publications

(19 citation statements)

References 11 publications

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“…The relationship between xerostomia and oral candidiasis was investigated in the monkey model (133), as described earlier in this review. Jorge et al (83) used Wistar rats to further study this phenomenon. They rendered 20 Wistar rats xerostomic by surgical removal of the major salivary glands (parotid, sublingual, and submandibular) and orally inoculated them with C. albicans three times a week for 32 weeks.…”

Section: Wistar Rat Modelmentioning

confidence: 99%

“…Other predisposing factors for oral candidiasis that have come under scrutiny in a number of animal models include broad-spectrum antibiotic therapy (5,82,(155)(156)(157), carbohydrate-rich diets (66,154,155), topical use of corticosteroids (47), corticosteroid inhalation (28), trauma (131), iron deficiency (147,185), diabetes (51), xerostomia (1,83,84,119,133), decrease in CD4 ϩ T-cell counts and phagocytic function (31,32), defective T-cell function (16), and immunosuppressive therapy (27,172). Undoubtedly, these studies have helped us to understand the etiology of oral candidiasis and the development of the management protocols that are currently prevalent.…”

Section: Need For and Clinical Relevance Of Animal Modelsmentioning

confidence: 99%

“…The protective role of saliva in preventing oral candidiasis has been studied previously in the Wistar rat model (83,84). To further investigate this in SD models, hyposalivatory rats have been used (119).…”

Section: Sprague-dawley Rat Modelmentioning

confidence: 99%

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Experimental Oral Candidiasis in Animal Models

2001

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Oral candidiasis is as much the final outcome of the vulnerability of the host as of the virulence of the invading organism. We review here the extensive literature on animal experiments mainly appertaining to the host predisposing factors that initiate and perpetuate these infections. The monkey, rat, and mouse are the choice models for investigating oral candidiasis, but comparisons between the same or different models appear difficult, because of variables such as the study design, the number of animals used, their diet, the differences in Candida strains, and the duration of the studies. These variables notwithstanding, the following could be concluded. (i) The primate model is ideal for investigating Candida-associated denture stomatitis since both erythematous and pseudomembranous lesions have been produced in monkeys with prosthetic plates; they are, however, expensive and difficult to obtain and maintain. (ii) The rat model (both Sprague-Dawley and Wistar) is well proven for observing chronic oral candidal colonization and infection, due to the ease of breeding and handling and their ready availability. (iii) Mice are similar, but in addition there are well characterized variants simulating immunologic and genetic abnormalities (e.g., athymic, euthymic, murine-acquired immune deficiency syndrome, and severe combined immunodeficient models) and hence are used for short-term studies relating the host immune response and oral candidiasis. Nonetheless, an ideal, relatively inexpensive model representative of the human oral environment in ecological and microbiological terms is yet to be described. Until such a model is developed, researchers should pay attention to standardization of the experimental protocols described here to obtain broadly comparable and meaningful data

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Section: Wistar Rat Modelmentioning

confidence: 99%

Section: Need For and Clinical Relevance Of Animal Modelsmentioning

confidence: 99%

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Experimental Oral Candidiasis in Animal Models

2001

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“…Long term of smoking will change salivary flow rates and pH of saliva [2,6,15,24,25]. The change of salivary flow rates has important role in pathogenesis of candidiasis [17,21,22]. Smoking also causes decreasing the antibody in saliva, and affects the amount of microorganism in saliva.…”

Section: Resultsmentioning

confidence: 99%

“…Research done by Navazesh et al (1995) showed relation that inversely proportional between salivary flow rate and amount of candida in saliva [21,22]. The research done by Torrest et al (2002) also proved that subject with low salivary flow rate has higher amount of candida [23].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Salivary Flow Rates and The Amount of Candida in Saliva in Smokers

Nelis¹

2018

Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)

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Abstract-Smoking is one of the predisposing factors for oral candidiasis. The mechanism is possibly caused by chemical substances in cigarettes that can provide nutritionS for candida, local changes in epithelium that which leads to candida colonization, decreased antibodies in saliva and decreased salivary flow rates. The objective of this study was to investigate the relationship between salivary flow rates and the amount of Candida in smoker's saliva. This research was an observational analytic with cross sectional design. The samples consist of 40 healthy smokers with age range between 20-45 years. The method used to collect unstimulated salivary is spitting method. Quantity of candida is counted using colony counter and ISO 7218 formula. Data was analyzed by Anova and Pearson correlation. The result showed that the difference of average candida in every group of salivary flow rates was not significant (p=0.852). Pearson correlation analysis confirmed that correlation were in the weak category (close to 0) with value of significance 0.308. As conclusion, salivary flow rates didn't have significant effect toward amount of candida in the smoker's saliva.

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Innate Defense Mechanisms in Oral Candidiasis

Dongari-Bagtzoglou

2005

Fungal Immunology

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Oral candidiasis established in the sialoadenectomised rat

Cited by 26 publications

References 11 publications

Experimental Oral Candidiasis in Animal Models

Experimental Oral Candidiasis in Animal Models

Relationship between Salivary Flow Rates and The Amount of Candida in Saliva in Smokers

Innate Defense Mechanisms in Oral Candidiasis

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