Oral candidiasis in patients hospitalised in the intensive care unit: Diagnosis through clinical and cytopathological examinations

Freire, Fabiane Marques Dos Santos; Marques, Letícia Côgo; Silva, Natasha Camargo Da; Cunha, Karin Soares Gonçalves; Conde, Danielle Castex; Milagres, Adrianna; Gonçalves, Lúcio Souza; Silva, Arley

doi:10.1111/cyt.13243

Cytopathology

2023

DOI: 10.1111/cyt.13243

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Oral candidiasis in patients hospitalised in the intensive care unit: Diagnosis through clinical and cytopathological examinations

Fabiane Marques Dos Santos Freire

Letícia Côgo Marques

Natasha Camargo Da Silva

et al.

Abstract: Objective: To evaluate the prevalence and clinical aspects of oral candidiasis in patients hospitalised in the intensive care unit.Methods: This is a longitudinal and prospective study that included 48 participants hospitalised in the intensive care unit. Sociodemographic data, presence of systemic disorders, use of medications, laboratory tests, cause of hospital admission, type of breathing, and length of hospital stay were obtained from medical records. Oral How to cite this article: dos Santos Freire FM, M… Show more

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2024

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Early Candida colonisation impact on patients and healthcare professionals in an intensive care unit

Dalben,

Pimentel,

Maifrede

et al. 2024

Mycoses

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ObjectivesCandida spp. is an opportunistic pathogen that causes superficial and invasive infections with nosocomial outbreaks without strict hygiene protocols. Herein, we assessed oral colonisation by Candida spp. in 209 Intensive Care Unit (ICU) patients between July 2021 and April 2022, conducting clinical, epidemiological, and microbiological characterisation of those developing oral or invasive candidiasis.MethodsInitial oral swabs were collected within 24 h of admission in the ICU, followed by collections on Days 2, 4, 6 and 8. Swabs from denture‐wearing patients, abiotic surfaces, healthcare professionals' hands, and retroauricular regions were also obtained. Recovered yeasts and filamentous fungi were identified using MALDI‐TOF MS and morphological characteristics, respectively. Genetic similarity of Candida spp. isolates was evaluated using Amplified fragment length polymorphism (AFLP), and the antifungal susceptibility profile was determined by broth microdilution.ResultsIn the study, 64.11% of patients were orally colonised by Candida spp. Of these, 80.59% were colonised within the first 24 h. Oral colonisation also occurred on subsequent days: 50%/Day 2, 26.92%/Day 4, and 11.53%/Days 6 and 8. Of the patients, 8.61% had oral candidiasis, mainly pseudomembranous. Among orally colonised patients, 2.23% developed invasive candidiasis. Besides, 89.47% of healthcare professionals evaluated were colonised. MALDI‐TOF MS identified different yeast species, and C. albicans (45.34%), C. tropicalis (15.7%), and C. parapsilosis sensu stricto (9.88%) were the most prevalent. AFLP analysis indicated a high genetic correlation (≥97%) between C. parapsilosis sensu stricto isolates from patients and professionals. Three resistant C. albicans isolates were also found.ConclusionThis study reported a diversity of yeast and filamentous fungi species in ICU patients and highlighted early Candida spp. colonisation risks for invasive candidiasis, as well as the potential horizontal transmission in the nosocomial setting, emphasising the need for effective infection control measures.

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Early Candida colonisation impact on patients and healthcare professionals in an intensive care unit

Dalben,

Pimentel,

Maifrede

et al. 2024

Mycoses

View full text Add to dashboard Cite

show abstract

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Oral candidiasis in patients hospitalised in the intensive care unit: Diagnosis through clinical and cytopathological examinations

Cited by 1 publication

References 51 publications

Early Candida colonisation impact on patients and healthcare professionals in an intensive care unit

Early Candida colonisation impact on patients and healthcare professionals in an intensive care unit

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