Oral candidiasis prevalence in human immunodeficiency virus-1 and pulmonary tuberculosis coinfection: A systematic review and meta-analysis

Peña, Diana Estefania Ramos; Innocentini, Lara Maria Alencar Ramos; Saraiva, Maria da Conceição Pereira; Lourenço, Alan Grupioni; Motta, Ana Carolina Fragoso

doi:10.1016/j.micpath.2020.104720

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…However, various other Candida species (Candida tropicalis, Candida parapsilosis, Candida dubliniensis, Candida famata, Candida krusei, and Candida glabrata) have also contributed. 1,12,13,25,30,36,[39][40][41][42][43][44] Candida dubliniensis was found relatively more often in HIV-infected individuals. 45 Oral candidiasis in HIV infection has a variety of clinical patterns (pseudomembranous, erythematous, hyperplastic, and angular cheilitis), as seen in all the cases.…”

Section: Discussionmentioning

confidence: 95%

Clinical Assessment and Management in Improving the Quality of Life of HIV/AIDS Patients with Oral Candidiasis: A Case Series

Novianti,

Sufiawati

2023

HIV

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Introduction: Oral candidiasis is the most prevalent opportunistic infection in patients with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS), impacting their quality of life. This report aims to emphasize the importance of clinical assessment and management of HIV/AIDS patients with oral candidiasis to improve their quality of life. Case: Five male patients, aged between 32 and 71 years, came to the HIV clinic and complained of white plaques in their mouths and painful swallowing. The World Health Organization's (WHO) clinical staging of all patients was 4. Three patients had not yet received antiretroviral therapy (ART), and their total lymphocyte counts (TLC) of <1.170 cells/mm 3 . Two patients had dropped out of ART with CD4 counts were <40 cells/mm 3 . The body mass index of two patients was underweight, while the others were normal. The oral hygiene index simplified (OHI-S) of the patients was fair to poor. The quality of life assessment using the oral health impact profile 14 (OHIP-14) questionnaires before therapy showed values from 6-20. Clinical examination defined the diagnosis as oral candidiasis, exfoliative cheilitis, oral hairy leukoplakia, and a cytomegalovirus-related ulcer. Case Management: The patients were treated with fluconazole, 0.2% chlorhexidine gluconate mouthwash, 2% miconazole cream, diphenhydramine, and multivitamins. The oral lesions were improved within 14 days to a month of treatment, and OHIP-14 scores were significantly reduced (0-3). Conclusion: Clinical assessment is important in managing HIV/AIDS patients with oral candidiasis, which improves the patient's quality of life. Therefore, routine clinical assessment and management of HIV/AIDS patients are strongly recommended.

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Section: Discussionmentioning

confidence: 95%

Clinical Assessment and Management in Improving the Quality of Life of HIV/AIDS Patients with Oral Candidiasis: A Case Series

Novianti,

Sufiawati

2023

HIV

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“…Two issues have not been resolved in this regard: the toxicity of antifungals and the development of resistance by Candida species or the colonization of Candida species resistant to antifungals. Some antifungals have been reported to increase their power by acting by contact (topically) [ 27 ]. To our knowledge, no local side effects, such as type I hypersensitivity or contact stomatitis, have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, Candida spp. arises as a highly potential pathogenic fungus in patients with HIV and bronchopulmonary diseases [ 27 ].…”

Section: Brief Overview Of Hiv and Candida Sppmentioning

confidence: 99%

Punica granatum as Anticandidal and Anti-HIV Agent: An HIV Oral Cavity Potential Drug

Huerta-Reyes

Gaitán-Cepeda

Sánchez-Vargas

2022

Plants

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The oral cavity is crucial from diagnosis to adherence to HAART therapy in the HIV/AIDS population; consequently, drugs that can maintain healthy conditions in the oral cavity are necessary for patients with HIV/AIDS. Punica granatum (pomegranate) is a tree that has been employed extensively for centuries in the traditional medicine of ancient cultures for the treatment of a wide range of diseases, including oral and dental diseases. In recent decades, its potent anticandidal properties have been shown, especially on Candida albicans, the cause of the most common clinical manifestation in HIV patients. The present work contributes to the review of the anti-HIV and anticandidal properties of the plant species P. granatum as involved with the oral cavity. The literature reviewed revealed that crude extracts of pomegranate and its main isolated compounds possess inhibitory activity on different HIV targets, including binding viral proteins and the three replicative HIV enzymes. In addition, in the literature reviewed, pomegranate exhibited anticandidal effects on 10 different species. Thus, pomegranate appears to be an excellent candidate to explore and incorporate into the treatment of the oral cavity of HIV/AIDS patients, in that, in addition to its pharmacological effects such as antiviral and anticandidal, pomegranate represents an easily available, inexpensive, and safe natural source.

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“…The oral cavity is the house of an exclusive complexed ecosystem called oral microbiota which is constructed of hundreds of fungal and bacterial species, one of the very important microbiota is CA. In addition, that CA is the most common opportunistic ubiquitous yeast which is the most etiological agent of invasive and mucosal human fungal infections 52,53 .…”

Section: Introductionmentioning

confidence: 99%

Oral candidiasis of tobacco smokers: A literature review

El-Sakhawy¹,

Donia²,

Kobisi³

et al. 2023

Pakistan J. of Biological Sciences

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The mouth is a vital point of entry into the human body, the health of the mouth entails mental, physical as well as social well-being. Studying diseases, microbiota and environmental conditions of the mouth is important to maintain oral health and all body. The smoke of tobacco cigarettes is one of the worst habits that affect the health of the mouth and the body. Therefore, this review has been conducted to study the effect of smoking on the balance of the oral microbiota and the opportunistic organisms, one of the most important of them Candida. Although a few studies have found that cigarette smoking does not influence carriage by Candida significantly. However, most of the studies had results completely contrary to that, smoking cigarettes affect Candida pathogenic characteristics such as a transition from yeast to hyphal form, biofilm formation and, virulence-related gene expressions. Tobacco is not only an inducer of the transition process but it considers an excellent medium for this process. Furthermore, smoking was significantly associated with Candida pathogenicity in patients with clinically suspected oral leukoplakia and smoking worsens oral candidiasis and dampens epithelial cell defense response. Nicotine significantly altered the composition and proportion of yeast cells, as well as the extracellular polysaccharide amounts which increase biofilm matrix and thickness which could promote oral candidiasis. Smoking has the potential to alter the oral condition and cause severe oxidative stress, thereby damaging the epithelial barrier of the mouth. These oxidative molecules during smoking activate epithelial cells proteins called oxidative stress-sensing proteins. If some of these proteins induced, widely thought to have anti-inflammatory properties, inhibit the secretion of pro-inflammatory cytokines and are linked to inflammation and oxidative stress is thought to be a possible therapeutic objective and a crucial regulator for smoking-related oral diseases and mouth candidiasis for instance leukoplakia. Also, it is transported into the cell nucleus in the existence of additional electrophilic chemicals to activate antioxidant enzyme gene expression. Therefore, smoking cigarettes destroys oral health and consequently destroys the health of the whole body.

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Oral candidiasis prevalence in human immunodeficiency virus-1 and pulmonary tuberculosis coinfection: A systematic review and meta-analysis

Cited by 4 publications

References 14 publications

Clinical Assessment and Management in Improving the Quality of Life of HIV/AIDS Patients with Oral Candidiasis: A Case Series

Clinical Assessment and Management in Improving the Quality of Life of HIV/AIDS Patients with Oral Candidiasis: A Case Series

Punica granatum as Anticandidal and Anti-HIV Agent: An HIV Oral Cavity Potential Drug

Oral candidiasis of tobacco smokers: A literature review

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