Oral cavity response to air pollutant exposure and association with pulmonary inflammation and symptoms in asthmatic children

He, Linchen; Norris, Christina; Cui, Xiaojie; Li, Zhen; Barkjohn, Karoline K.; Teng, Yanbo; Lin, Fang; Lin, Lili; Wang, Qian; Zhou, Xin; Hong, Jian‐Guo; Li, Feng; Zhang, Yinping; Schauer, James J.; Black, Marilyn; Bergin, Michael H.; Zhang, Junfeng Jim

doi:10.1016/j.envres.2021.112275

Cited by 15 publications

(6 citation statements)

References 81 publications

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“…Exposure to air pollution causes inflammation in the oral cavity, which may exacerbate airway inflammation and asthma symptoms. He et al [ 39 ] reported that asthmatic children had an elevated salivary IL-6 level, a biomarker of an increased PM 2.5 level, and exacerbation of asthma symptoms. They used a specific sensor which checked the average of weekly exposure for each individual and also used the analysis technology suggested in previous research [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Biomarkers of the relationship of particulate matter exposure with the progression of chronic respiratory diseases

Kim,

Chung,

Kim

2024

Korean J Intern Med

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A high level of particulate matter (PM) in air is correlated with the onset and development of chronic respiratory diseases. We conducted a systematic literature review, searching the MEDLINE, EMBASE, and Cochrane databases for studies of biomarkers of the effect of PM exposure on chronic respiratory diseases and the progression thereof. Thirty-eight articles on biomarkers of the progression of chronic respiratory diseases after exposure to PM were identified, four of which were eligible for review. Serum, sputum, urine, and exhaled breath condensate biomarkers of the effect of PM exposure on chronic obstructive pulmonary disease (COPD) and asthma had a variety of underlying mechanisms. We summarized the functions of biomarkers linked to COPD and asthma and their biological plausibility. We identified few biomarkers of PM exposure-related progression of chronic respiratory diseases. The included studies were restricted to those on biomarkers of the relationship of PM exposure with the progression of chronic respiratory diseases. The predictive power of biomarkers of the effect of PM exposure on chronic respiratory diseases varies according to the functions of the biomarkers.

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Section: Resultsmentioning

confidence: 99%

Biomarkers of the relationship of particulate matter exposure with the progression of chronic respiratory diseases

Kim,

Chung,

Kim

2024

Korean J Intern Med

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“…Fine particulate matter (PM 2.5 ) and ozone (O 3 ) were also measured by the air sensor box used in this study [ 22 , 23 ]. We further calculated personal exposures to PM 2.5 and O 3 , as they might affect asthma symptoms [ 16 , 17 , 24 ]. The detailed method for personal air pollution exposure assessment has been published previously [ 25 ], and the results are shown in S3 Table .…”

Section: Methodsmentioning

confidence: 99%

Associations between personal apparent temperature exposures and asthma symptoms in children with asthma

He,

Evans,

Norris

et al. 2023

PLoS ONE

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Ambient temperature and relative humidity can affect asthma symptoms. Apparent temperature is a measure of temperature perceived by humans that takes into account the effect of humidity. However, the potential link between personal exposures to apparent temperature and asthma symptoms has not been investigated. We conducted a panel study of 37 asthmatic children, aged 5–11 years, during an early spring season (average daily ambient temperature: 14°C, range: 7–18°C). Asthma symptoms were measured 4 times for each participant with a 2-week interval between consecutive measurements using the Childhood Asthma-Control Test (C-ACT). Average, minimum, and maximum personal apparent temperature exposures, apparent temperature exposure variability (TV), and average ambient temperature were calculated for the 12 hours, 24 hours, week, and 2 weeks prior to each visit. We found that a 10°C lower in 1-week and 2-week average & minimum personal apparent temperature exposures, TV, and average ambient temperature exposures were significantly associated with lower total C-ACT scores by up to 2.2, 1.4, 3.3, and 1.4 points, respectively, indicating worsened asthma symptoms. Our results support that personal apparent temperature exposure is potentially a stronger driver than ambient temperature exposures for the variability in asthma symptom scores. Maintaining a proper personal apparent temperature exposure could be an effective strategy for personalized asthma management.

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“…Tobacco smoke exposure, either first-or second-hand, has similar effects and may also trigger severe exacerbations [167]. In a prospective study of asthmatic Thai children, daily PM 2.5 exposure to levels above 12 mcg/m 3 was associated with asthma exacerbation within the next three days [168]. Accumulating evidence suggests that longterm exposure to air pollution, especially traffic-related air pollution (TRAP), can contribute to new-onset asthma in children and adults [169][170][171].…”

Section: Environmental Exposuresmentioning

confidence: 99%

Prediction of Asthma Exacerbations in Children

Sarikloglou,

Fouzas,

Paraskakis

2023

JPM

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Asthma exacerbations are common in asthmatic children, even among those with good disease control. Asthma attacks result in the children and their parents missing school and work days; limit the patient’s social and physical activities; and lead to emergency department visits, hospital admissions, or even fatal events. Thus, the prompt identification of asthmatic children at risk for exacerbation is crucial, as it may allow for proactive measures that could prevent these episodes. Children prone to asthma exacerbation are a heterogeneous group; various demographic factors such as younger age, ethnic group, low family income, clinical parameters (history of an exacerbation in the past 12 months, poor asthma control, poor adherence to treatment, comorbidities), Th2 inflammation, and environmental exposures (pollutants, stress, viral and bacterial pathogens) determine the risk of a future exacerbation and should be carefully considered. This paper aims to review the existing evidence regarding the predictors of asthma exacerbations in children and offer practical monitoring guidance for promptly recognizing patients at risk.

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Oral cavity response to air pollutant exposure and association with pulmonary inflammation and symptoms in asthmatic children

Cited by 15 publications

References 81 publications

Biomarkers of the relationship of particulate matter exposure with the progression of chronic respiratory diseases

Biomarkers of the relationship of particulate matter exposure with the progression of chronic respiratory diseases

Associations between personal apparent temperature exposures and asthma symptoms in children with asthma

Prediction of Asthma Exacerbations in Children

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