Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient

Biomarkers in fibromyalgia: a review

“…Cordero et al have published work on the efficacy of coenzyme Q10 in relieving pain and other FM symptoms. 25,26 Similar results were found by Miyamae et al, who studied the oral supplementation with coenzyme Q10 in ten juvenile FM patients. 27 However, even if oxidative stress plays a pivotal role in FM, there aren't any specific biomarkers able to evaluate it.…”

“…18 Another example of how biomarkers could be used to better assess both syndrome severity and therapy response is represented by plasma coenzyme Q10 levels: it has been shown that where supplementation with coenzyme Q10 obviously led to increased plasmatic levels, at the same time, patients seemed to report an improvement of pain. 25,26 However, the results observed in the literature are not consistent and far from allow the use of such biomarkers, in clinical practice, to assess patients' outcomes in an effective and reliable way. Nonetheless, the genetic studies discussed here, despite being nonhomogeneous in terms of study design and methods, were focused on the same pathway (nociception) and found alterations in biogenic amine expression (5HT, noradrenaline, and dopamine) and metabolism (catechol-O-methyltransferase [COMT] and monoamine oxidase [MAO] enzymes).…”

“…For instance, few works describe the clinically significant improvement of FM patients treated with oral supplementation of coenzyme Q10, a cofactor known to play an important role in the scavenging of reactive oxygen species. 25,26 Coenzyme Q10 is a membrane stabilizer and a vital cofactor in the mitochondrial electron transport chain, enabling the generation of adenosine triphosphate (ATP). Cordero et al have published work on the efficacy of coenzyme Q10 in relieving pain and other FM symptoms.…”

Recomendações Nutricionais Para O Tratamento Da Fibromialgia

“…Dessa forma, os artigos que foram lidos na íntegra e não incluídos na análise crítica, por não preencherem os critérios de inclusão, muitas vezes foram citados na discussão. Os temas abordados nesses artigos foram o estresse oxidativo e a suplementação com coenzima Q10 (coQ10), 25,[27][28][29][30]32 composição corporal e sintomas da fibromialgia 35,37,39 e deficiência de vitamina D e sua influência na fibromialgia. 41 17 os autores analisaram artigos sobre dietas vegetarianas, ricas em antioxidantes, embora existam poucos estudos e com número pequeno de indivíduos.…”

“…Contudo, mais investigações são necessárias para esclarecer mecanismos precisos pelos quais a CoQ10 pode contribuir para os processos patológicos e terapêuticos. 27 A suplementação com a coenzima Q10 (CoQ10) melhorou o sono e o estado de alerta mental, reduziu a dor nas articulações, episódios e intensidade de dor de cabeça, número de tender points e peroxidação lipídica, além de melhorar sintomas de fadiga, depressão e ansiedade. [28][29][30] A disfunção mitocondrial pode estar envolvida em diversos sintomas observados na fibromialgia.…”