Oral contraception, body mass index, and asthma: A cross-sectional Nordic-Baltic population survey

Macsali, Ferenc; Real, Francisco Gómez; Omenaas, Ernst; Bjørge, Line; Janson, Christer; Franklin, Karl A.; Svanes, Cecilie

doi:10.1016/j.jaci.2008.10.041

Cited by 57 publications

(51 citation statements)

References 42 publications

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“…By stratifying the analyses by body mass index, the increased risk of asthma and allergy was specific to normal weight and overweight women but not in lean women. 18 Both the independent associations between use of oral contraceptive pills and its interaction with body mass index as observed in Macsali et al study are contrary to our observations. Overall, the use of combined oral contraceptives was equivocally associated with reductions in asthma care episodes in our study.…”

Section: Discussioncontrasting

confidence: 99%

“…By assuming a conservative prevalence of current use of any hormonal contraceptives among women 16-45 years at 30% and a 20% prevalence of ever having physician-diagnosed asthma (as reported in the combined 2008 and 2010 Scottish Health Surveys), we estimated that we would need a sample size of 2494 to have 90% power to detect an odds ratio of 1.40 for the use of combined oral contraceptives. 18 …”

Section: Sample Size Determinationmentioning

confidence: 99%

“…Our secondary aim was to investigate whether there is any evidence of biological interaction between use of hormonal contraceptives and body mass index in relation to the risk of asthma. 18 …”

Section: Introductionmentioning

confidence: 99%

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Hormonal contraceptives and asthma in women of reproductive age: analysis of data from serial national Scottish Health Surveys

Nwaru

Sheikh

2015

J R Soc Med

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Objectives: Sex steroid hormones may explain known gender-related variations in asthma prevalence and clinical manifestation. We investigated the relationship between use of hormonal contraceptives and asthma in women, and assessed evidence of biological interaction between use of hormonal contraceptives and body mass index in this relationship. Design: Population-based analysis using data from serial Exposure: Current use of hormonal contraceptives. Main outcome measures: Self-reported current physiciandiagnosed asthma, current wheezing symptoms, wheezing attacks and treatment for asthma or wheeze. Results: Women comprising 30.9% (95% confidence interval 29.3-32.5) were currently using any hormonal contraceptive and current physician-diagnosed asthma was present in 6.5% (95% confidence interval 5.7-7.4). Use of any hormonal contraceptive was associated with reduced risk of current physician-diagnosed asthma (odds ratio 0.68; 95% confidence interval 0.47-0.98) and receiving !3 asthma care episodes (odds ratio 0.45; 95% confidence interval 0.25-0.82), but the evidence was equivocal for wheezing attacks. Use of hormonal contraceptives among overweight or obese women was non-statistically significantly associated with asthma, but there was 42-135% increased risk in overweight and obese non-contraceptive using women. Conclusions: Use of hormonal contraceptives may reduce asthma exacerbations and number of care episodes. Overweight and obese non-contraceptive-using women may be at increased risk of asthma. Prospective studies are now needed to confirm these findings. Both oestrogen and progesterone may stimulate smooth airway muscle function and inhibit the activities of TH2 responses. Future studies should investigate these underlying mechanisms.

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Section: Discussioncontrasting

confidence: 99%

Section: Sample Size Determinationmentioning

confidence: 99%

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Hormonal contraceptives and asthma in women of reproductive age: analysis of data from serial national Scottish Health Surveys

Nwaru

Sheikh

2015

J R Soc Med

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“…7,36 Some studies have suggested that use of contraceptives is a risk factor for development or exacerbation of asthma crises. 7,36 The association between asthma and use of combined contraceptives (estrogen and progesterone) is unclear.…”

Section: Use Of Hormone Contraceptives and Asthmamentioning

confidence: 99%

“…5 Among adults, epidemiological studies have demonstrated that the prevalence of asthma is higher among females than among males. [6][7][8] The relationship between sex hormones and asthma has been evaluated in several studies. 9,10 Sex-related differences in the risk, incidence and pathogenesis of a variety of lung diseases exist in humans.…”

Section: Introductionmentioning

confidence: 99%

Association between asthma and female sex hormones

Baldaçara

Silva

2017

Sao Paulo Med. J.

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CONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de São Paulo (Unifesp). METHODS:We searched the CAPES journal portal, a Brazilian platform that provides access to articles in the MEDLINE, PubMed, SciELO, and LILACS databases. The following keywords were used based on Medical Subject Headings: asthma, sex hormones, women and use of oral contraceptives. RESULTS:The associations between sex hormones and asthma remain obscure. In adults, asthma is more common in women than in men. In addition, mortality due to asthma is significantly higher among females. The immune system is influenced by sex hormones: either because progesterone stimulates progesterone-induced blocking factor and Th2 cytokines or because contraceptives derived from progesterone and estrogen stimulate the transcription factor GATA-3. CONCLUSIONS:The associations between asthma and female sex hormones remain obscure. We speculate that estrogen fluctuations are responsible for asthma exacerbations that occur in women. Because of the anti-inflammatory action of estrogen, it decreases TNF-α production, interferon-γ expression and NK cell activity. We suggest that further studies that highlight the underlying physiopathological mechanisms contributing towards these interactions should be conducted. RESUMO CONTEXTO E OBJETIVO:A relação entre os hormônios sexuais e a asma tem sido investigada em diversos estudos. Esta revisão tem como objetivo descrever a relação entre hormônios sexuais (endógenos e exó-genos) e a inflamação nas vias aéreas, especialmente na asma, em eventos diferentes (na asma pré-menstrual, durante o uso de anticoncepcionais, na menopausa, no uso de terapia hormonal e na gestação). TIPO DE ESTUDO E LOCAL:Revisão narrativa da literatura médica, Universidade Federal do Tocantins (UFT) e Universidade Federal de São Paulo (Unifesp). MÉTODO: Pesquisamos o Portal de Periódicos Capes, uma plataforma brasileira que fornece acesso a artigos nas bases de dados MEDLINE, PubMed, SciELO e LILACS. Os descritores utilizados foram asma, hormônios sexuais, mulheres e uso de anticoncepcionais, com base no "Medical Subject Headings". RESULTADOS: As associações entre hormônios sexuais e asma ainda permanecem obscuras. Em adultos, a asma é mais frequente em mulheres do que em homens. Além disso, a mortalidade por asma é significativamente maior no sexo feminino, destacando-se que o sistema imunológico sofre influência de hormônios sexuais, seja porque a progesterona estimula o fator bloqueador induzido pela progesterona e citocinas Th2 ou porque contraceptivos derivados de progesterona e estrógeno estimulam o fator de transcriç...

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Association of Estrogen-Related Traits with Allergic Rhinitis

Kliś

Wronka

2017

Advances in Experimental Medicine and Biology

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Estrogen's role in allergic diseases has recently been of considerable interest. The present article seeks to determine the relationship between estrogen-dependent traits and allergic rhinitis. The following traits were considered: digit ratio, age at menarche, regularity of menstrual cycles, and the waist to hip ratio. The study consisted of surveys and measurement data collected from 768 female university undergraduates. One hundred and sixty eight undergraduates (21.9%) had been diagnosed with allergic rhinitis. The results of logistic regression show that in women with a high digit ratio, indicating exposure to a higher estrogen level in the prenatal period, the risk of allergic rhinitis was almost twice as high as that in those with an average value of the ratio. The difference in the digit ratio was greater for the right than left hand. A significantly higher risk of allergic rhinitis was also observed in women who experienced first menstruation at a younger age. No differences in risk of allergic rhinitis were noted due to general obesity, abdominal obesity, or irregularity of menstrual cycles. We conclude that a higher digit ratio is suggestive of a propensity to allergies in adulthood plausibly having to do with greater exposure to estrogen at early stages of ontogenetic development.

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Oral contraception, body mass index, and asthma: A cross-sectional Nordic-Baltic population survey

Cited by 57 publications

References 42 publications

Hormonal contraceptives and asthma in women of reproductive age: analysis of data from serial national Scottish Health Surveys

Hormonal contraceptives and asthma in women of reproductive age: analysis of data from serial national Scottish Health Surveys

Association between asthma and female sex hormones

Association of Estrogen-Related Traits with Allergic Rhinitis

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