Oral Contraceptives and Malignant Hepatoma

Glassberg, AlanB.; Rosenbaum, ErnestH.

doi:10.1016/s0140-6736(76)91494-x

Cited by 31 publications

(2 citation statements)

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“…Long-term oral contraceptives, androgenic and anabolic steroid administration has been shown to be associated with an increased incidence of nodular hyperplasia of the liver, hepatic adenomas and hepatocellular carcinomas (Glassberg & Rosenbaum, 1976;Henderson et al, 1983). More commonly these hormones also induce vascular changes in the liver varying from focal dilatation of the periportal sinusoids to the presence of large parenchymal channels engorged with blood, the condition known as peliosis hepatis (Winkler & Poulsen, 1975;Zafrani et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Fatal intraperitoneal haemorrhage of hepatic origin

Fidas-Kamini

Busuttil

1986

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 99%

Fatal intraperitoneal haemorrhage of hepatic origin

Fidas-Kamini

Busuttil

1986

Postgraduate Medical Journal

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“…Subsequently, Meyer et al ( 2 1) described an 18-year-old who developed a hepatoblastoma after taking oral contraceptives for 15 months. A recent report describes a patient with hepatocellular carcinoma developing in both lobes after 11 years of birth control pills (22). In the most extensive series to date, Mays et al (23) report nine benign and four malignant hepatic tumors in women taking birth control pills.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma in a young woman with prolonged exposure to oral contraceptives

Gattanell

Perloff

Holland

1978

Med. Pediatr. Oncol.

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A case of hepatocellular carcinoma in a young female is presented in which the apparent etiology was the use of oral contraceptives for 5 1/2 years. Sequential therapeutic trials with intraarterial 5-fluorouracil, intraarterial adriamycin, and intravenous 1,3 bis[2-chloroethyl]-1-nitrosourea (BCNU) were unsuccesful. The adverse effects of oral contraceptives on the structure and function of hepatic tissue are reviewed.

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Multiple hepatic adenomas and a hepatocellular carcinoma in a man on oral methyl testosterone for eleven years

Boyd

Mark

1977

Cancer

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NDROGENIC, ESTROGENIC, AND PROCES-A togenic steroids all exert a metabolic and morphologic effect on the The female and male hormones have different but overlapping effects on the liver. Ingestion of estrogens and progesterones is associated with intrahepatic cholestasis, rise in serum transaminase, increased Bromsulphalein retention, and focal nodular hyperplasia. Ingestion of androgens is associated with cholestasis, peliosis hepatis, and hepatocellular carcinoma. The progesterones and 17-alkylated anabolic steroids affect mainly the smooth endoplasmic reticulum, whereas estrogens affect mainly protein synthesis in rough endoplasmic reticulum. All patients developing jaundice or hepatocellular carcinoma after treatment with anabolic steroids invariably have received compounds containing a methyl or ethyl group at the 17 position, e.g., oxymetholone or methyltestosterone. More From the .James Homer

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Oral Contraceptives and Malignant Hepatoma

Cited by 31 publications

References 8 publications

Fatal intraperitoneal haemorrhage of hepatic origin

Fatal intraperitoneal haemorrhage of hepatic origin

Hepatocellular carcinoma in a young woman with prolonged exposure to oral contraceptives

Multiple hepatic adenomas and a hepatocellular carcinoma in a man on oral methyl testosterone for eleven years

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