Oral controlled release drug delivery system and Characterization of oral tablets; A review

Abstract

Oral route of drug administration is considered as the safest and easiest route of drug administration. Control release drug delivery system is the emerging trend in the pharmaceuticals and the oral route is most suitable for such kind of drug delivery system. Oral route is more convenient for It all age group including both pediatric and geriatrics. There are various systems which are adopted to deliver drug in a controlled manner to different target sites through oral route. It includes diffusion controlled drug delivery systems; dissolution controlled drug delivery systems, osmotically controlled drug delivery systems, ion-exchange controlled drug delivery systems, hydrodynamically balanced systems, multi-Particulate drug delivery systems and microencapsulated drug delivery system. The systems are formulated using different natural, semi-synthetic and synthetic polymers. The purpose of the review is to provide information about the orally controlled drug delivery system, polymers which are used to formulate these systems and characterizations of one of the most convenient dosage form which is the tablets.

Sustained Release for St. John?s Wort: A Rational Idea?

“…Dissolution target profiles with drug release longer than 8 hours demand for hydrodynamic systems (floating systems) that float over the gastric content for a prolonged period of time [39] while drug release. The active substance is secreted this way into small intestine continuously, where absorption processes can take place.…”

Recent advances in "smart" delivery systems for extended drug release in cancer therapy

“…Diffusion system -reservoir [159][160][161] Drug-coated with polymers and released through slow diffusion out of the polymer Drugs with higher molecular weight have difficulty diffusing through the membrane Diffusion system -matrix 162 Drug dispersed within the polymer and diffuses slowly Matrix device cannot achieve zero-order release Dissolution reservoir 163 Drug coated with slowly dissolving surface Different drug solubility and half-lives need to be considered Dissolution matrix 164,165 Drug placed in a slowly dissolving matrix Different drug solubility and half-lives need to be considered Osmotic systems [166][167][168][169] Drug surrounded by semipermeable membrane held in a rigid tablet with laser drilled holes; as the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure pushes the active drug through the opening in the tablet…”

In vitro and ex vivo assessment of hydrophilic polymer‐ and plasticizer‐based thin buccal films designed by using central composite rotatable design for the delivery of meloxicam

“…They dissolve or disintegrate in the oral cavity, without the need of water, offering a suitable way of medicating to special population groups who have difficulty swallowing, as well as to the general population. [10,11] Meloxicam (MLX), the member of the oxicam family is a non-steroidal anti-inflammatory drug (NSAID) and belongs to BCS class II drugs. [5,6] Numerous film forming polymers are reported in literatures which are effectively used in buccal films.…”