Oral Crohn's disease with late intestinal manifestations

Ghandour, Khalil; Issa, M A

doi:10.1016/0030-4220(91)90495-x

Cited by 39 publications

(18 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These oral lesions may predate bowel symptoms by years 7. Various studies have looked at the prevalence of asymptomatic intestinal Crohn’s disease in patients presenting with oral lesions and this ranges from 0 to 48% 8…”

mentioning

confidence: 99%

Search for Mycobacterium paratuberculosis DNA in orofacial granulomatosis and oral Crohn’s disease tissue by polymerase chain reaction

Riggio¹,

Gibson²,

Lennon³

et al. 1997

Gut

View full text Add to dashboard Cite

Background-Although intestinal Crohn's disease has long been suspected to have a mycobacterial cause, possible mycobacterial involvement in orofacial granulomatosis (OFG) and oral lesions of Crohn's disease has not yet been investigated. Aims-As the slow growing Mycobacterium paratuberculosis has been implicated in the aetiology of intestinal Crohn's disease, the potential involvement of this mycobacterial species in OFG and oral lesions of Crohn's disease was investigated. Patients-To attempt detection of the organism in OFG and oral Crohn's disease tissue samples, a polymerase chain reaction (PCR) assay was used on archival formalin fixed, paraYn wax embedded oral tissue sections from 30 patients with OFG, seven with Crohn's disease, and 12 normal controls. Methods-The PCR assay used was based on primers targeting the 5' region of the multicopy IS900 DNA insertion element of the M paratuberculosis genome. In order to achieve maximum sensitivity, two rounds of PCR were carried out and amplicons confirmed by Southern blot hybridisation to a digoxigenin labelled IS900 DNA probe. Results-None of the OFG and oral lesions of Crohn's disease samples were positive for M paratuberculosis and all normal controls were also negative. Conclusions-These results suggest that M paratuberculosis may not be a major aetiological agent in OFG or oral Crohn's disease lesions, although the use of paraffin wax embedded tissue as opposed to fresh tissue as a sample source could underestimate the true prevalence of the organism. (Gut 1997; 41: 646-650)

show abstract

mentioning

confidence: 99%

Search for Mycobacterium paratuberculosis DNA in orofacial granulomatosis and oral Crohn’s disease tissue by polymerase chain reaction

Riggio¹,

Gibson²,

Lennon³

et al. 1997

Gut

View full text Add to dashboard Cite

show abstract

“…Several cases of nasal involvement in CD have been published, the first in 1985 (Kinnear, 1985;Ghandour and Issa, 1991;Ernst et al, 1993;Pochon et al, 1995;Ferjaoui et al, 1999;Kriskovich et al, 2000;Ulnick et al, 2001;Venail et al, 2002;Merkonidis et al, 2005;Kryssia and Henry, 2006;Sari et al, 2007;Michailidou et al, 2009). Saddle nose deformity in a patient with CD was first described by Merkonidis et al (2005).…”

Section: Discussionmentioning

confidence: 95%

“…The mucocutaneous manifestations of Crohn's disease in the orofacial region are multiple, including oral Crohn's disease, metastatic Crohn's disease in sites noncontiguous with the bowel system, and reactive disorders such as pyoderma gangrenosum . Nasal manifestations are extremely rare and only a few cases have been reported up to date in the literature (Kinnear, 1985;Ghandour and Issa, 1991;Ernst et al, 1993;Pochon et al, 1995;Ferjaoui et al, 1999;Kriskovich et al, 2000;Ulnick and Perkins, 2001;Venail et al, 2002;Merkonidis et al, 2005;Kryssia and Henry, 2006;Sari et al, 2007;Michailidou et al, 2009). Persistent truncus arteriosus is an uncommon congenital cardiac malformation accounting for approximately 1.2% of all congenital heart malformations (Friedman, 1997;Williams et al, 1999).…”

Section: Introductionmentioning

confidence: 95%

Saddle nose deformity, palatal perforation and truncus arteriosus in a patient with Crohn’s disease

Oğhan

Pekkan

Özveren

2012

Journal of Cranio-Maxillofacial Surgery

View full text Add to dashboard Cite

“…Sattelnasendeformi t ä ten ist in der Literatur bisher nicht diskutiert worden. Muschelteilresektionen wurden durchgef ü hrt [107] . Au ß erdem k ö nnen Heruntergeladen von: WEST VIRGINIA UNIVERSITY.…”

Section: Abb 5 Mikroskopische Polyangiitis Prominente Gef ä ß E In unclassified

Rhinochirurgie bei Systemerkrankungen

Sachse¹,

Stoll²

2010

Laryngo-Rhino-Otol

View full text Add to dashboard Cite

Systemic disorders represent a heterogenous group of diseases which can primarily manifest at the nose and sinuses as limited disease or secondarily as part of the systemic involvement. Rhinologists therefore play an important role in the diagnostic but also therapeutic process. Although therapy of systemic disorders is primary systemic, additional nasal surgery may become necessary. Surgical procedures include sinus surgery for the treatment of complications of the orbit and the lacrimal duct, septorhinoplasty due to saddle nose deformity and closure of septal perforation. Since many systemic disorders represent very rare diseases, recommendations are based on the analysis of single case reports and studies with a limited number of patients. Even though data is still limited, experiences published so far have shown that autogenous cartilage or bone transplants can be used in nasal reconstruction of deformities caused by tuberculosis, leprosy, wegener's granulomatosis, sarcoidosis and relapsing polychondritis. Experiences gained from these diseases support our observation that well-established techniques of septorhinoplasty can be used in systemic disorders as well. However, reaching a state of remission is an essential condition before considering any rhinosurgery in these patients. Under these circumstances revision surgery has to be expected more frequently compared to the typical collective of patients undergoing septorhinoplasty. These observations in part may also be useful for the treatment of nasal septal perforations since implantation of cartilage- or bone grafts represents an essential step in the closure of septal perforations. Apart from the treatment of orbital complications, sinus surgery has been proven beneficial in reducing nasal symptoms and increasing quality of life in patients refractory to systemic treatment.

show abstract

Oral Crohn's disease with late intestinal manifestations

Cited by 39 publications

References 4 publications

Search for Mycobacterium paratuberculosis DNA in orofacial granulomatosis and oral Crohn’s disease tissue by polymerase chain reaction

Search for Mycobacterium paratuberculosis DNA in orofacial granulomatosis and oral Crohn’s disease tissue by polymerase chain reaction

Saddle nose deformity, palatal perforation and truncus arteriosus in a patient with Crohn’s disease

Rhinochirurgie bei Systemerkrankungen

Contact Info

Product

Resources

About