Oral delivery of hydrophobic flavonoids and their incorporation into functional foods: Opportunities and challenges

Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies

“…10), in close agreement with other microphysiological models of the placenta. 23,[25][26][27][28][29][30][31][32][33][34] One group of chips was fixed with paraformaldehyde to arrest any physiological activity within the cells, including glucose transporters while maintaining structural integrity; 94 this setup was used as a positive control for this experiment. Placental glucose transport post-fixation with paraformaldehyde resulted in the highest percentage In summary, we demonstrated that overall placental glucose transport was unaffected regardless of exposure, suggesting that low levels of inflammation induced by these compounds did not significantly impact glucose transport at concentrations even higher than those reported in adverse pregnancy outcomes.…”

“…The latest advancements in the placenta OOC model have been recently summarized by Elzinga et al 22 The most widely described models include two-cell chips, which have trophoblasts and endothelial cell compartments. [23][24][25][26][27][28][29][30][31][32] Single-cell chips have also been developed, in which only trophoblast cells are maintained, 33,34 while a three-chamber chip has also been developed from the Menon Laboratory, which includes cytotrophoblasts, syncytiotrophoblasts, and endothelial cells. 21 The main thrust of the study is to provide a new model that incorporates multiple cells representative of the placental architecture while preserving necessary intercellular connections through microchannels.…”

“…The latest advancements in the placenta OOC model have been recently summarized by Elzinga et al 22 The most widely described models include two-cell chips, which have trophoblasts and endothelial cell compartments. 23–32 Single-cell chips have also been developed, in which only trophoblast cells are maintained, 33,34 while a three-chamber chip has also been developed from the Menon Laboratory, which includes cytotrophoblasts, syncytiotrophoblasts, and endothelial cells. 21…”

Bioavailability Improvement Strategies for Icariin and Its Derivates: A Review

“…Absorption enhancers are a widely used method for increasing the water solubility of poorly soluble drugs. The better solubilization of those bioactive compounds leads to increased intestinal absorption, thus improving their bioavailability [ 103 ]. The flavonoids can be hydrolyzed into their secondary glycoside and aglycone forms.…”

Synergistic Effect of Acarbose–Chlorogenic Acid on α-Glucosidase Inhibition: Kinetics and Interaction Studies Reveal Mixed-Type Inhibition and Denaturant Effect of Chlorogenic Acid

“…14 Despite the challenges that accompany natural food-based therapeutics such as low bioavailability and biostability, the potential of food-derived compounds as drug adjuvants is a promising method of treatment that is easily implementable. 15,16 For example, the use of natural compounds as an adjuvant in treating diseases is a research area gaining traction. Additionally, supplementing drug therapy with natural compounds known to have similar biofunctional activities can allow for the minimization of drug reliance and their resulting side effects while maintaining the desired treatment outcome.…”