Oral field cancerization: A critical appraisal

Desai, Rajiv S.; Shirsat, Pankaj M; Bansal, Shivani; Prasad, Pooja; Arvandekar, Ankita Satish

doi:10.1016/j.oraloncology.2021.105304

Cited by 4 publications

(5 citation statements)

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“…Oral cancer patients often show multiple cancers in the oral cavity and other organs, such as the upper gastrointestinal tract. This phenomenon is explained by the concept of “field cancerization” proposed by Slaughter, et al in 1953 [ 12 ], but the risk factors may involve not only smoking and alcohol drinking, but also the oral microbiome and virome [ 13 – 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Oral cancer patients frequently have multiple primary cancers in the oral cavity and other organs, such as the upper gastrointestinal tract and lungs [7][8][9][10][11]. Such phenomena are explained by the concept of field cancerization and cell competition, in which various gene mutations and epigenetic abnormalities accumulate in tissues and organs that have been exposed to cancer-inducing factors over a prolonged period [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Detection of Merkel cell polyomavirus in multiple primary oral squamous cell carcinomas

et al. 2023

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Oral microbiome studies have mainly focussed on bacteria, with the relationship between viruses and oral cancers remaining poorly understood. Oral cancers can develop even in the absence of any history of daily smoking or drinking. Oral cancer patients frequently have multiple primary cancers in the oral cavity and other organs, such as the upper gastrointestinal tract. Merkel cell polyomavirus (MCPyV) is a novel oncovirus identified from a subtype of skin cancer in 2008. In this study, we investigated the potential involvement of MCPyV in the pathogenesis of oral squamous cell carcinoma (OSCC). Participants comprised 115 Japanese patients with OSCC (single primary: 109 tumours in 109 patients; multiple primaries: 16 tumours in 6 patients) treated in our department between 2014 and 2017. DNA was extracted from formalin-fixed paraffin-embedded specimens of primary lesions. MCPyV DNA copy counts were analysed by quantitative real-time polymerase chain reaction. Twenty-four of the 115 patients (20.9%) were positive for MCPyV DNA. No association was found between presence or absence of MCPyV DNA and clinical characteristics other than number of primary lesions. The MCPyV DNA-positive rate was significantly higher for multiple primary OSCCs (62.5%, 10/16 tumours) than for single primary OSCCs (16.5%, 18/109 tumours; P < 0.001). Furthermore, MCPyV DNA load was significantly higher for patients with multiple primaries (P < 0.05). MCPyV was observed more frequently and DNA load was significantly higher with multiple primary OSCCs than with single primary OSCC. MCPyV may play some role as an oncovirus for multiple primary OSCCs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of Merkel cell polyomavirus in multiple primary oral squamous cell carcinomas

et al. 2023

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“…1 In 1953, Slaughter published an article emphasizing the importance of examining and investigating the "field" surrounding an oral cancer lesion. 8 This should be done at the risk-assessment stage and must be part of the comprehensive management of oral cancer. Since then, many studies have used molecular techniques to explore this concept.…”

Section: Introductionmentioning

confidence: 99%

Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders

et al. 2023

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Background: Oral cancer therapy, such as radiation or surgical treatment, has pernicious long-term effects that patients suffer throughout their life, the disability being considerable with delayed diagnosis. It is well known that many oral cancers develop from oral potentially malignant disorders (OPMDs). Patients diagnosed with OPMDs may have an increased risk of developing cancer anywhere in the oral cavity. Early detection and intervention could be essential prevention strategies to inhibit oral cancer progression. OPMDs may not immediately develop into carcinoma. However, this condition provides a “field” of specific abnormalities wherein evolving altered genetic cells can be explained with the “field cancerization” concept. Purpose: This review aims to describe the “field cancerization” concept in oral cancer and OPMD, which is expected to contribute to a better clinical management strategy for oral cancer prevention. Review: “Oral field cancerization” describes oral cancers that develop in multifocal areas of pre-cancerous changes. It can be found as histologically abnormal tissue surrounding the tumor, suggesting that oral cancer often consists of multiple independent lesions. Conclusion: The oral field cancerization concept should prompt healthcare professionals to remind their patients that frequent oral examination with histological studies and molecular testing is mandatory for those at high risk of developing malignancies.

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“…: A critical appraisal' that recently appeared in JOMFP. [ 1 ] Oral lichen planus (OLP) is a common condition. Review articles have suggested a varied prevalence of OLP-0.5–2.2%, 1–2%, 0.1–4% and 1.27%.…”

mentioning

confidence: 99%

“…Although rightly pointed out in the article by Desai et al .,[ 1 6 ] that it is rather improbable for the majority of OLP cases to transform into oral squamous cell carcinoma (OSCC); the status of OLP as an oral potentially malignant disorder (OPMD) cannot be entirely dismissed. One of the first studies conducted by Krutchkoff et al ., 1978[ 7 ] acknowledged that patients with OLP have a higher propensity to develop carcinomas but did not believe there was enough evidence to accept that OLP has the biological potential to progress into cancer.…”

mentioning

confidence: 99%