Basaloid squamous cell carcinoma (BSCC) is a rare, unique, and aggressive variant of squamous cell carcinoma which mostly occurs in the upper aerodigestive tract. Histologically and immunologically different from conventional squamous cell carcinoma, it is mostly seen in men of the sixth and seventh decades and is commonly associated with tobacco and alcohol usage. BSCC usually presents as a high stage disease with distant metastasis, high recurrence rate, and poor prognosis. In the head-and-neck region, BSCC has a strong predilection for sites such as the base of the tongue, soft palate, and epiglottis. Less commonly, it may also occur on the floor of the mouth, gingiva, and tonsils. In the present article, we report a case of BSCC in the right maxillary anterior gingiva of a 57-year-old female for its rarity.

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Background: The influence of environmental factors on dental caries is a well-established fact; however, little is known about the impact of genetics on the caries process. Aims: This study was aimed to analyse the association between the vitamin D receptor (VDR) gene polymorphism and dental caries. It also compared the risk of dental caries between individuals with homozygous (tt and TT) genotype and heterozygous (Tt) genotype. Further, this study also aimed to compare VDR gene polymorphism by gender. Methodology: A total of 196 subjects were selected based on their decayed, missing, filled teeth (DMFT) index according to the WHO guidelines (1997), and were divided into two groups based on caries experience. The case group was further classified into low and high caries groups. The saliva samples were collected, DNA was extracted, and VDR Taq1 (T/C) gene polymorphism was analysed by polymerase chain reaction–based restriction fragment length polymorphism (PCR-RFLP) and visualized under 2% agarose gel. Results: There was no significant difference in the VDR Taq1 polymorphism and dental caries between the case and control group. However, further stratification showed a statistically significant difference based on caries experience in the study group. The heterozygous mutant genotype (Tt) was associated with a higher caries experience (62.1%) (P = 0.008) with the frequency of ‘t’ allele being 77% as compared to ‘T’ allele (63.6%) in the high caries group. Conclusion: VDR Taq1 gene polymorphism does not seem to have a role in the incidence of dental caries in the studied population; however, it may have a role in the severity of the caries process.