Oral Focal Acantholytic Dyskeratosis

Zunt, Susan L.; Tomich, Charles E.

doi:10.1111/j.1524-4725.1990.tb00072.x

Cited by 11 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The etiology of oral WD/FAD is also unknown. Some authors have suggested a role for local trauma (10, 12), and others have considered a role for tobacco (4, 9, 11). Taken together, the data of the present analysis of the literature revealed that smoking appears to be the most prevalent predisposing factor, with about 60% of the 41 reported lesions appearing in smokers.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Warty dyskeratoma/focal acantholytic dyskeratosis – an update on a rare oral lesion

Allon

Buchner

2011

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…They are uncommon and except for one series (9), most reported cases are either single case reports or reports of 2-3 cases. Owing to the paucity of the reports, many aspects of the oral lesions have not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

Warty dyskeratoma/focal acantholytic dyskeratosis – an update on a rare oral lesion

Allon

Buchner

2011

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…1 These variants may be observed not only in the classical dermatoses that coined the term but also in various other skin diseases such as Grover's disease, acantholytic acanthoma, 2 warty dyskeratoma, 3 linear epidermal naevus, 4 naevus corniculatus, 5 oral focal dyskeratosis 6 and acantholytic dermatosis localized to the vulvocrural area. 1 These variants may be observed not only in the classical dermatoses that coined the term but also in various other skin diseases such as Grover's disease, acantholytic acanthoma, 2 warty dyskeratoma, 3 linear epidermal naevus, 4 naevus corniculatus, 5 oral focal dyskeratosis 6 and acantholytic dermatosis localized to the vulvocrural area.…”

mentioning

confidence: 99%

“…The four major patterns of acantholysis are mainly defined by the level of clefting and include: (i) the acantholytic dyskeratotic pattern of Darier's disease; (ii) acantholysis in the entire epidermis as observed in Hailey±Hailey disease; and (iii) a suprabasal (vulgaris); as well as (iv) a superficial (seborrhoeic) type of pemphigus pattern. 1 These variants may be observed not only in the classical dermatoses that coined the term but also in various other skin diseases such as Grover's disease, acantholytic acanthoma, 2 warty dyskeratoma, 3 linear epidermal naevus, 4 naevus corniculatus, 5 oral focal dyskeratosis 6 and acantholytic dermatosis localized to the vulvocrural area. 7 All patterns of acantholysis may also occur as an incidental histopathological finding, remaining subclinical in many inflammatory and neoplastic skin diseases, for example: leucocytoclastic vasculitis, 1 pityriasis rosea, chondrodermatitis nodularis helicis, 8 dermatofibroma, 9 basal cell carcinoma 1 and also in acral lentiginous malignant melanoma.…”

mentioning

confidence: 99%

A localized variant of paraneoplastic pemphigus: acantholysis associated with malignant melanoma

et al. 2001

View full text Add to dashboard Cite

We report a 72-year-old male patient with a nodular malignant melanoma that was associated with focal suprabasal acantholysis (FSA). This phenomenon, which is regarded as an incidental finding by dermatopathologists, may be associated with inflammatory and also neoplastic skin diseases. Haematoxylin and eosin stained sections from an erythematous plaque surrounding the patient's tumour showed FSA, direct immunofluorescence (DIF) and indirect immunofluorescence (IIF) on normal human skin, monkey oesophagus and rat urinary bladder were negative. On electron microscopy few desmosomes could be detected in the basal cell layer of the acantholytic areas and there was a nearly complete loss of these structures in the spinous cell layer. Only remnants of cytoplasmic plaques and keratin filaments could be observed in those areas. In contrast, adherens junctions appeared to be well preserved. An enzyme-linked immunosorbent assay (ELISA) using recombinant fusion proteins as antigens did not show circulating autoantibodies against desmoglein 1 (Dsg1) or desmoglein 3 (Dsg3). In contrast, immunoblotting revealed autoantibodies directed against keratinocyte antigens with a molecular weight of 85 kDa and 250 kDa, the first band corresponding to the molecular weight of comigrating plakoglobin. Immunoprecipitation with patient serum also revealed a 85-kDa band. We conclude that these autoantibodies, probably in conjunction with cofactors produced by the tumour, could play a part in the pathogenesis of this variant of FSA, for which we propose the term 'localized paraneoplastic pemphigus.'

show abstract

“…Tlie specfrum of disorders with fhe histopathologic pattern of localized aeantholytic dyskeratosis has also been enlarged in the last few years. Formerly, they were limited to classic warty dyskeratoma, a localized form of acanfliolytic dyskeralosis involving to the infundibular epithelium (8), but foei of localized acantholytic dyskeratosis have also been described invoh ing the oral mucosa (oral focal acantholytic dyskeratosis) (11). Brownstein found acantholytic patterns of pemphigus \ tilgaris, pemphigus vegetans, superficial pemphigus, and Hailey-Hailey disease in a series of 31 solitary keratotic papules or nodules.…”

Section: Discussionmentioning

confidence: 99%

Incidental acantholysis

et al. 1993

View full text Add to dashboard Cite

The incidental finding of microscopic foci of acantholytic dyskeratosis, reproducing the histological pattern of Darier's disease, has been the subject of a number of papers in the last few years. In contrast, the incidental finding of other types of acantholysis has not been mentioned in the literature. In the last 5 years, we have noticed such a microscopic finding in 14 biopsy specimens (0.15% of our cutaneous specimens). they were from 13 patients (7 men and 6 women); their ages ranged from 37 to 79 years (mean, 63). Three lesions were located on the head, 7 on the trunk, and 4 on the limbs. The histological diagnoses were basal cell carcinoma (6 cases), keratoacanthoma (2 cases), psoriasis (2 cases), elastolytic granuloma, acral arteriovenous angioma, tinea corporis, and leukocytoclastic vasculitis (1 case each). The histological patterns of the acantholytic foci simulated pemphigus vulgaris (9 cases), superficial pemphigus (1 case), Hailey-Hailey disease (3 cases), and unclassifiable acantholysis (1 case). None of the patients had familial or personal history of acantholytic disorders. We propose a classification of the primary acantholytic disorders based on both their acantholytic pattern and their clinical extent.

show abstract

Oral Focal Acantholytic Dyskeratosis

Cited by 11 publications

References 22 publications

Warty dyskeratoma/focal acantholytic dyskeratosis – an update on a rare oral lesion

Warty dyskeratoma/focal acantholytic dyskeratosis – an update on a rare oral lesion

A localized variant of paraneoplastic pemphigus: acantholysis associated with malignant melanoma

Incidental acantholysis

Contact Info

Product

Resources

About