Oral gliadin‐protected superoxide dismutase in addition to phototherapy for treating non‐segmental vitiligo: A 24‐week prospective randomized placebo‐controlled study

Fontas, Éric; Montaudié, Henri; Passeron, Thierry

doi:10.1111/jdv.17331

Cited by 17 publications

(16 citation statements)

References 25 publications

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“…Due to differences in patient selection, protocols, mixture of compounds used in trials, poor methodology in some studies using these different combinations of antioxidants and a lack of corroborating reports, there is little or no consensus on their use for vitiligo. There is, however, some evidence for improvement with the combination of phototherapy with oral antioxidants like Polypodium leucotomos and gliadin‐protected superoxide dismutase (SOD) 46,48,49 . RCTs with good methodology and reproducible results are needed to fully consider the use of antioxidants and vitamins in vitiligo.…”

Section: Resultsmentioning

confidence: 99%

Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force—Part 2: Specific treatment recommendations

Seneschal,

Speeckaert,

Taïeb

et al. 2023

Acad Dermatol Venereol

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BackgroundThe treatment of vitiligo can be challenging. Up‐to‐date agreed consensus recommendations on the use of topical and systemic therapies to facilitate the clinical management of vitiligo are currently lacking.ObjectivesTo develop internationally agreed‐upon expert‐based recommendations for the treatment of vitiligo.MethodsIn this consensus statement, a consortium of 42 international vitiligo experts and four patient representatives participated in different online and live meetings to develop a consensus management strategy for vitiligo. At least two vitiligo experts summarized the evidence for different topics included in the algorithms. A survey was then given to a core group of eight experts to resolve the remaining issues. Subsequently, the recommendations were finalized and validated based on further input from the entire group during two live meetings.ResultsThe recommendations provided summarize the latest evidence regarding the use of topical therapies (steroids, calcineurin inhibitors and Jak‐inhibitors) and systemic therapies, including steroids and other systemic immunomodulating or antioxidant agents. The different modalities of phototherapies (NB‐UVB, photochemotherapy, excimer devices and home phototherapy), which are often combined with other therapies, are also summarized. Interventional approaches as well as depigmentation strategies are presented for specific indications. Finally, the status of innovative and targeted therapies under development is discussed.ConclusionsThis international consensus statement culminated in expert‐based clinical practice recommendations for the treatment of vitiligo. The development of new therapies is ongoing in vitiligo, and this will likely improve the future management of vitiligo, a disease that still has many unmet needs.

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Section: Resultsmentioning

confidence: 99%

Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force—Part 2: Specific treatment recommendations

Seneschal,

Speeckaert,

Taïeb

et al. 2023

Acad Dermatol Venereol

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“…In a different study, the addition of oral gliadin‐protected superoxide dismutase to NB‐UVB yielded better treatment outcomes 29 . In the combination therapy group, the Vitiligo Extent Score had a mean improvement of 19.85%, compared to 8.83% in the monotherapy group.…”

Section: Combination Therapymentioning

confidence: 95%

An update and review of narrowband ultraviolet B phototherapy for vitiligo

Wang

Rodrigues

2022

Dermatological Reviews

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Vitiligo is a chronic skin condition that results in depigmentation. It affects up to 2% of the population worldwide. Phototherapy is one of the most commonly used treatment methods for vitiligo. In the last few decades, there has been an increasing popularity of narrowband ultraviolet B phototherapy (NB-UVB) over other forms of phototherapy to treat vitiligo. This paper reviews efficacy and safety of NB-UVB treatment in vitiligo, including combination therapy with topical calcineurin inhibitors, corticosteroids, vitamin D analogs, antioxidants, and fractional CO 2 laser.Advantages and limitations of home-based phototherapy as an emerging alternative to conventional hospital-based phototherapy will also be explored.

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“…The following options are reported: Phototherapy with topicals: Generally, the combination of phototherapy with topicals (both calcineurin inhibitors, topical steroids and topical ruxolitinib) achieves better efficacy 40‐44 . As to which combination is better, the number of published studies is currently too limited to make a fair judgment. Combination with systemic antioxidants: There is some evidence to recommend the combination of phototherapy with oral antioxidants like polypodium leucotomos and gliadin‐protected SuperOxide Dismutase (SOD) for achieving better repigmentation 45‐47 Combination of systemic immunosuppressives with phototherapy: Most systemic immunosuppressive therapies can induce repigmentation when given in combination with phototherapy 48 .…”

Section: Treatment Recommendationsmentioning

confidence: 99%

Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the International Vitiligo Task Force Part 1: towards a new management algorithm

van Geel,

Speeckaert,

Taïeb

et al. 2023

Acad Dermatol Venereol

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BackgroundThe treatment of vitiligo can be challenging and depends on several factors such as the subtype, disease activity, vitiligo extent, and treatment goals. Vitiligo usually requires a long‐term approach. To improve the management of vitiligo worldwide, a clear and up‐to‐date guide based on international consensus with uniform stepwise recommendations is needed.ObjectivesTo reach an international consensus on the nomenclature and to develop a management algorithm for the diagnosis, assessment, and treatment of vitiligo.MethodsIn this consensus statement, a consortium of 42 international vitiligo experts and four patient representatives participated in online and live meetings to develop a consensus management strategy for vitiligo. At least two vitiligo experts summarized the evidence of topics included in the algorithms. A survey was utilized to resolve remaining issues among a core group of eight experts. Subsequently, the unanimous recommendations were finalized and validated based on further input from the entire group during two live meetings.ResultsThe algorithms highlight the importance of shared decision‐making. Dermatologists are encouraged to provide patients with detailed explanations of the prognosis and expected therapeutic outcomes based on clinical examination. The treatment goal should be discussed and clearly emphasized to patients given the different approaches for disease stabilization and repigmentation. The evaluation of disease activity remains a cornerstone in the tailor‐made approach to vitiligo patients.ConclusionsThese new treatment algorithms are intended to guide clinical decision‐making in clinical practice. Promising novel therapies for vitiligo are on the horizon, further highlighting the need for reliable outcome measurement instruments and greater emphasis on shared decision‐making.

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Oral gliadin‐protected superoxide dismutase in addition to phototherapy for treating non‐segmental vitiligo: A 24‐week prospective randomized placebo‐controlled study

Cited by 17 publications

References 25 publications

Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force—Part 2: Specific treatment recommendations

Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force—Part 2: Specific treatment recommendations

An update and review of narrowband ultraviolet B phototherapy for vitiligo

Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the International Vitiligo Task Force Part 1: towards a new management algorithm

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