1990
DOI: 10.1016/0190-9622(90)70174-g
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Oral hairy leukoplakia

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Cited by 39 publications
(12 citation statements)
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“…It appears that by inducing cell proliferation and enhancing cell survival within the lesion, the transforming proteins create an optimal environment for viral replication, subsequent infection of neighboring cells, and possible superinfection of infected cells, which results in the intertypic recombinants characteristic of HLP (40). Interestingly, the expression of these proteins is dependent on viral replication within HLP, as administration of the antiviral agent acyclovir, which targets the viral DNA polymerase, terminates expression of all viral proteins within HLP, transforming and replicative alike (35).…”
Section: Discussionmentioning
confidence: 99%
“…It appears that by inducing cell proliferation and enhancing cell survival within the lesion, the transforming proteins create an optimal environment for viral replication, subsequent infection of neighboring cells, and possible superinfection of infected cells, which results in the intertypic recombinants characteristic of HLP (40). Interestingly, the expression of these proteins is dependent on viral replication within HLP, as administration of the antiviral agent acyclovir, which targets the viral DNA polymerase, terminates expression of all viral proteins within HLP, transforming and replicative alike (35).…”
Section: Discussionmentioning
confidence: 99%
“…While EBV infection in B cells usually results in one of the latent forms of infection, infection of oral epithelial cells (as exemplified by the lateral tongue lesion oral hairy leukoplakia) (39) is normally completely lytic (53). Nevertheless, in the epithelial tumor nasopharyngeal carcinoma, most cells contain the type II form of latent viral infection, and only a small percentage of tumor cells are lytically infected (33).…”
mentioning
confidence: 99%
“…The detection of Epstein-Barr virus (EBV) DNA in the epithelial cells is confirmatory for the diagnosis of this lesion 5 , OHL is clinically described as asymptomatic non-removable white patch with corrugated surface. This white lesion can be distinguished by the formation of vertical grooves most commonly seen on the sides of the tongue, often bilaterally 7 . Clinical differential diagnosis is based on the exclusion of irritative hyperkeratosis, pseudomembranous candidiasis, lichen planus and white sponge nevus.…”
Section: Introductionmentioning
confidence: 99%