Oral health and risk for head and neck squamous cell carcinoma: the Carolina Head and Neck Cancer Study

Abstract

Objective-Recent reports have linked oral health and periodontal disease indicators with increased risk of squamous cell carcinoma of head and neck (SCCHN). Thus far, evidence has been inconclusive; our objective was to study the association between oral health and SCCHN risk in the context of a large population-based study. Methods NIH Public Access Author ManuscriptCancer Causes Control. Author manuscript; available in PMC 2011 April 1. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript assessed using interview data on tooth loss and mobility, mouthwash use, and frequency of dental visits.Results-Subjects were 26-80 years old (median age = 61). The distribution of tooth loss among controls was 0-5 teeth = 60%; 5-14 = 15%; and 16-28 = 25%. After controlling for covariates, tooth loss did not yield any notable association with SCCHN (16-28 vs. 0-5 lost teeth: OR: 1.21, 95% CI: 0.94, 1.56). Self-reported history of tooth mobility was moderately associated with increased SCCHN risk (OR: 1.33, 95% CI: 1.07, 1.65); however, the association did not persist among never smokers. Routine dental visits were associated with 30% risk reduction (OR: 0.68, 95% CI: 0.53, 0.87).Conclusions-These data provide support for a possible modest association of periodontal disease, as measured by self-reported tooth loss indicators, but not tooth loss per se, with SCCHN risk.

A Literature Analysis of the Risk Factors for Oral Cancer

“…This chronic infection and resultant low-grade systemic inflammatory response along with oxidative stress may be one possible pathway of carcinogenesis (Gasche et al, 2011). Also, the oral ecological shifts accompanying periodontal disease are characterized by proliferation of ketone-producing and nitratereducing microorganisms, which may contribute to increases in carcinogen concentrations (Divaris et al, 2010). Furthermore, several oral microorganisms can produce carcinogenic acetaldehyde from alcohol (Homann et al, 2000).…”

Existe associação entre doença periodontal e câncer? Análise investigativa clínica

“…A IL-6 induzida pela inflamação crônica também pode ocasionar a hipermetilação de genes supressores tumorais através da indução transcripcional e estabilização da DNMT1 (GASCHE et al, 2011;LOD et al, 2014;ROKAVEC;ONER;HERMEKING, 2016 Quanto aos estudos com enfoque nos CCP, a estratégia de utilizar a mobilidade dental como uma manifestação representativa da DP também já foi empregada (HUJOEL et al, 2003;DIVARIS et al, 2010). Outros parâmetros utilizados para sugerir a presença da periodontite foram:…”

“…• perda dentária auto relatada (WINN et al, 1991;MARSHALL et al, 1992;BUNDGAARD et al, 1995;HIRAKI et al, 2008;MICHAUD et al, 2008;DIVARIS et al, 2010;NARAYAN et al, 2014);…”

“…• questionários sobre cuidados com higiene oral e consultas odontológicas (ZHENG et al, 1990;WINN et al, 1991;MARSHALL et al, 1992;BUNDGAARD et al, 1995;VELLY et al, 1998;MORENO-LOPEZ et al, 2000;GARROTE et al, 2001;GUHA et al, 2007;REZENDE et al, 2008;HOLMES et al, 2009;DIVARIS et al, 2010;ELIOT et al, 2013;MOERGEL et al, 2013;NARAYAN et al, 2014);…”

“…Dos procedimentos, pouco mais de 51% foram realizados devido a DP, 35,4% devido à cárie, 9,5% por uma combinação de ambos e 3,5% por outras razões. Assim, é correto dizer que a perda dentária é o desfecho de uma série de eventos ocorridos ao longo da vida do indivíduo e sua relação com a DP pode ser confundida por inúmeros de fatores, como o autocuidado, acesso ao tratamento, nível e qualidade do tratamento recebido e fatores socioeconômicos DIVARIS et al, 2010). Desta forma, a despeito de seu emprego rotineiro, este critério não é o ideal para espelhar a ação da DP.…”