Oral health in patients with neurodegenerative and cerebrovascular disease: a retrospective study

Auerbacher, Marc; Gebetsberger, Lydia; Kaisarly, Dalia; Schmidmaier, Ralf; Hickel, Reinhard; Drey, Michael

doi:10.1080/09638288.2022.2088866

Cited by 9 publications

(2 citation statements)

References 28 publications

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“…Additionally, alternative approaches, e.g., behavior management, hypnodontia, or conscious sedation might increase treatment success [ 14 , 15 ]. Aside from these general professional framework conditions, patience, dedication, and the arrangement of enough time seem to be crucial factors in the achievement of amenability and compliance in patients with disablement [ 13 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Retrospective Evaluation of 20 Years of Outpatient Dental Services to Adults with Disabilities at the Dental Hospitals of the Medical University of Innsbruck, Austria

Schnabl,

Strohm,

Schummer

et al. 2024

Healthcare

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Disabled persons’ chairside dentistry is challenging. We aimed for a retrospective breakdown of dental services delivered to disabled patients by dental students and to discuss feasibility of a chairside approach. Consecutive patients, who received scheduled dental treatment by dental students from 2002 to 2021, were included. Demographic data, medical diagnoses, number of treatment sessions, performed treatments, and treatment break-offs were collected and analyzed with descriptive statistics. In total, 224 individuals with various disabilities (mean age 36.4 ± 14.6 years) received dental services in 2282 sessions altogether (10.3 ± 11. sessions per patient). Professional tooth cleaning was the most frequently provided treatment (55.8% of sessions). A total of 654 teeth were restored with fillings, 97 teeth were extracted, 56 teeth had endodontic treatment, and 25 removable dentures were fitted. Treatment break-off due to incompliance and referral to dental general anesthesia occurred in 74 patients (33%). Chairside treatment of disabled persons by dental students is feasible in many cases. Our study may serve as an incentive for clinicians/researchers to report on treatment modalities and outcomes of chairside dentistry in patients with special oral health care needs, preferably by the use of prospective study designs, to contribute data and strategies in the fight for control of oral health inadequacies.

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Section: Introductionmentioning

confidence: 99%

Retrospective Evaluation of 20 Years of Outpatient Dental Services to Adults with Disabilities at the Dental Hospitals of the Medical University of Innsbruck, Austria

Schnabl,

Strohm,

Schummer

et al. 2024

Healthcare

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“…P. gingivalis and gingipains have been identified in the bloodstream, cerebrospinal fluid, and brains of humans Dominy et al, 2019). Therefore, understanding the impact of gingipains upon ISRIBs efficacy in treating ALS may offer vital understanding for the use of ISRIB to treat ALS patients, especially as patients with neurodegenerative diseases often suffer from poor oral health (Auerbacher et al, 2022). Given that oral hygeine can be significantly improved by tooth brushing by non-dental professional in people with reduced ability to brush their own teeth (Barbe et al, 2021), understanding whether P. gingivalis infections may impact the efficacy this ISRIB derivative as an ALS treatment may guide to more thorough oral hygiene care in ALS patients.…”

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confidence: 99%

Crosstalk between host stress-induced translational control and infection by Porphyromonas gingivalis

Knowles¹

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Periodontitis, a chronic inflammatory gum disease, is caused in part by the periodontopathogen Porphyromonas gingivalis. Infection triggers activation of host inflammatory responses which induce stresses such as oxidative stress. Under such conditions, cells can activate the Integrated Stress Response (ISR), a signalling cascade which functions to determine cellular fate, by downregulating protein synthesis and either initiating a stressresponse gene expression program, or if stress cannot be overcome, initiating programmed cell death. Recent studies have implicated the ISR signalling in both host antimicrobial defences and within the pathomechanism of certain microbes. In this study, we investigated how P. gingivalis infection alters translation attenuation during oxidative stress-induced activation of the ISR pathway in oral epithelial cells. P. gingivalis infection alone did not result in ISR activation. In contrast, infection coupled with stress led to differential stress granule formation and composition, along with dysregulation of the microtubule network. Infection also heightened stress-induced translational repression, a response which could not be rescued by ISRIB, a potent ISR inhibitor. Heightened translational repression during stress was observed with both P. gingivalis conditioned media and outer membrane vesicles, implicating the role of a secretory factor, probably proteases known as gingipains, in this exacerbated translational repression. The effects of gingipain inhibitors and gingipains-deficient P. gingivalis mutants further confirmed these pathogen-specific proteases as the effector. Gingipains are known to degrade the mammalian target of rapamycin (mTOR) and these studies implicate the gingipain-mTOR axis as the effector of host translational dysregulation during stress.

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Oral Health—Bridging the Health Disparity Through Primary Care

Wallace,

Mayfield

2024

Advances in Family Practice Nursing

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Oral health in patients with neurodegenerative and cerebrovascular disease: a retrospective study

Cited by 9 publications

References 28 publications

Retrospective Evaluation of 20 Years of Outpatient Dental Services to Adults with Disabilities at the Dental Hospitals of the Medical University of Innsbruck, Austria

Retrospective Evaluation of 20 Years of Outpatient Dental Services to Adults with Disabilities at the Dental Hospitals of the Medical University of Innsbruck, Austria

Crosstalk between host stress-induced translational control and infection by Porphyromonas gingivalis

Oral Health—Bridging the Health Disparity Through Primary Care

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