Oral health status and risk of bacteremia following allogeneic hematopoietic cell transplantation

Sultan, Ahmed S.; Zimering, Yvette; Petruzziello, Gloria; Alyea, Edwin P.; Antin, Joseph H.; Soiffer, Robert J.; Ho, Vincent T.; Sonis, Stephen T.; Woo, Sook‐Bin; Marty, Francisco M.; Treister, Nathaniel S.

doi:10.1016/j.oooo.2017.06.003

Cited by 23 publications

(24 citation statements)

References 23 publications

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“…In this respect, it is important to mention that Kishimoto et al (2017) recently showed that intensity and duration of neutropenia is linked to oral mucositis and not to odontogenic infection during high-dose chemotherapy for hematological malignancies. In line with this observation, Sultan et al (2017) showed that oral health status was not associated with risk of bacteremia. Finally, it has to be noted that in hematologic patients undergoing high-dose chemotherapy and allogenic stem cell transplant, oral complications may last longer and be of a different kind due to graft-versus-host disease (Haverman et al, 2014).…”

Section: Hematolog I C Patientssupporting

confidence: 68%

Should oral foci of infection be removed before the onset of radiotherapy or chemotherapy?

et al. 2020

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An oral focus of infection is defined as a pathologic process in the oral cavity that does not cause major infectious problems in healthy individuals, but may lead to severe local or systemic inflammation under certain circumstances (Nabil & Samman, 2011; Sennhenn-Kirchner et al., 2009). Frequently observed potential oral foci of infection include caries profunda, periodontal disease, periapical problems, (partially) impacted or partially erupted teeth not fully covered by bone or showing radiolucency, cysts, non-vital pulps, and ulcerations (Ben

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Section: Hematolog I C Patientssupporting

confidence: 68%

Should oral foci of infection be removed before the onset of radiotherapy or chemotherapy?

et al. 2020

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“…149 There have been arguments that such infections could probably be of oral origin. [149][150][151] Hence in individuals undergoing dental procedures, particularly, those at a moderate to high risk of developing disseminated infections, it has been recommended that antibiotic prophylaxis be administered, [152][153][154][155] although consensus on the practice is in controversy. 156,157 The antibiotic that is routinely prescribed as prophylaxis in such individuals is amoxicillin.…”

Section: The Implications Of Mrsa Oral Carriage For Antibiotic Prophymentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus in the Oral Cavity: Implications for Antibiotic Prophylaxis and Surveillance

Donkor

Kotey

2020

Infect Dis (Auckl)

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The oral cavity harbors a multitude of commensal flora, which may constitute a repository of antibiotic resistance determinants. In the oral cavity, bacteria form biofilms, and this facilitates the acquisition of antibiotic resistance genes through horizontal gene transfer. Recent reports indicate high methicillin-resistant Staphylococcus aureus (MRSA) carriage rates in the oral cavity. Establishment of MRSA in the mouth could be enhanced by the wide usage of antibiotic prophylaxis among at-risk dental procedure candidates. These changes in MRSA epidemiology have important implications for MRSA preventive strategies, clinical practice, as well as the methodological approaches to carriage studies of the organism.

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“…The application of high-dose chemotherapy or a combination of high-dose chemotherapy and radiation of the body in the conditioning regimen prior to hematopoietic stem cell transplantation, as well as bone marrow aplasia within the first 3-4 weeks following transplantation are the causes of early complications in the form of febrile neutropenia and mucositis [28,37]. Pain and bleeding, xerostomia due to transient dysfunction of the salivary glands, taste disturbance and hypersensitivity of dentin may appear.…”

Section: Oral Changes After Hematopoietic Stem Cell Transplantationmentioning

confidence: 99%

“…Loss of antibodies and other antibacterial proteins, changes in the salivary glycoprotein concentration can compromise the barrier function of oral mucous membranes and increase the risk of developing infections. Poor oral hygiene, untreated caries and caries complications, extensive periodontal disease, and dental infections can be the cause of streptococcal bacteremia in the period immediately following the hematopoietic stem cell transplantation [29,37,38]. [6,38,39].…”

Section: Oral Changes After Hematopoietic Stem Cell Transplantationmentioning

confidence: 99%

Oral changes in patients before and after transplantation of solid organs and hematopoietic stem cells

et al. 2021

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Introduction/Objective. The aim of this paper is to point out the prevalence and severity of oral diseases in patients in the period before and after the transplantation of solid organs and hematopoietic stem cells. Methods. MEDLINE literature search was done via PubMed. Results. The development and improvement of transplantation medicine in specialized centers lead to an increasing number of patients, both adults and children, with transplanted solid organs and hematopoietic stem cells. Despite the success of therapy, numerous changes and complications can be observed on other organs in patients undergoing transplantation of solid organs and hematopoietic stem cells in the pre and post-transplant phase. Systemic diseases and conditions related to organ and cell transplantation, which are accompanied by numerous oral manifestations. The most common oral changes are gingival enlargement, desquamation of the oral epithelium, very painful ulcerations, polypoid and granulomatous changes in the oral mucosa, hard dental tissues with frequent complications, developmental anomalies of teeth in younger children, and in the later stage also the occurrence of oral cancer. After transplantation of solid organs and hematopoietic changes in the oral cavity and other organs occur depending on the patient?s post- transplantation period as well as on the applied immunosuppressive therapy. Conclusion. Oral changes development pre and post transplantation of solid organ and hematopoietic stem cells points to the importance of timely and good cooperation between the dentist and the doctor who treats the underlying disease.

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Oral health status and risk of bacteremia following allogeneic hematopoietic cell transplantation

Cited by 23 publications

References 23 publications

Should oral foci of infection be removed before the onset of radiotherapy or chemotherapy?

Should oral foci of infection be removed before the onset of radiotherapy or chemotherapy?

Methicillin-Resistant Staphylococcus aureus in the Oral Cavity: Implications for Antibiotic Prophylaxis and Surveillance

Oral changes in patients before and after transplantation of solid organs and hematopoietic stem cells

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