Oral histoplasmosis after radiation therapy for laryngeal squamous cell carcinoma

Ezzedine, Khaled; Accoceberry, Isabelle; Malvy, Denis

doi:10.1016/j.jaad.2006.10.026

Cited by 16 publications

(3 citation statements)

References 15 publications

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“…It is well known that disseminated disease is frequently seen in immunocompromised states such as HIV [4], as well as with hidden chronic immunosuppressive conditions such as extremes of age, diabetes and alcoholism and post radiotherapy for malignancies [3,6,9]. In 20% of patients there is no identified risk factor for dissemination [2,5,10].…”

Section: Discussionmentioning

confidence: 99%

Head and Neck Histoplasmosis—A Nightmare for Clinicians and Pathologists! Experience at a Tertiary Referral Cancer Centre

Viswanathan

Chawla

D’Cruz

et al. 2007

Head and Neck Pathol

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Histoplasmosis is a rarely reported deep mycotic infection in the Indian context. Oral or oropharyngeal manifestation can occur as an isolated symptom or as part of a disseminated process associated with immunosuppression especially with HIV and diabetes. Five cases of head and neck histoplasmosis accrued over 6 years in a tertiary referral cancer institute were reviewed. All these patients presented clinically as cancer. In three patients, the marked pseudoepitheliomatous hyperplasia led to a mistaken biopsy diagnosis of malignancy following which definitive surgical treatment was performed. The subsequent excision revealed typical features of histoplasmosis. Isolated oral presentation of histoplasmosis can mimic malignancy both clinically as well as pathologically, leading to potentially disastrous consequences. A high index of suspicion in those with overt or hidden immunosuppression and a deep wedge biopsy to demonstrate the organisms in the subepithelial tissue is recommended.

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Section: Discussionmentioning

confidence: 99%

Head and Neck Histoplasmosis—A Nightmare for Clinicians and Pathologists! Experience at a Tertiary Referral Cancer Centre

Viswanathan

Chawla

D’Cruz

et al. 2007

Head and Neck Pathol

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“…2 Infection occurs via inhalation of spores in soil containing bird and bat fecal matter. 3 In a healthy host, H capsulatum is rarely fatal and normally causes a self-limiting pneumonia, but in immunocompromised patients, it is more widespread and possibly fatal.…”

Section: Commentmentioning

confidence: 99%

Disseminated Trichosporon inkin and Histoplasma capsulatum in a patient with newly diagnosed AIDS

David

Martin

Deng

et al. 2008

Journal of the American Academy of Dermatology

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“…Of note is the increasing resistance of oral Bacteroides spp to penicillin and of Eikenella corrodens to clindamycin. Fungal causes, such as histoplasmosis in susceptible hosts living in endemic areas, also can occur [55]. Tuberculosis needs to be considered in the microbiologic investigation of prevertebral space infection, as in Pott's disease.…”

Section: Infections Of Deep Fascial Spacesmentioning

confidence: 99%

Microbiologic Investigations for Head and Neck Infections

Roscoe

Hoang

2007

Infectious Disease Clinics of North America

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A variety of methods, including direct examination of stained smears, antigen detection, routine and special cultures, and histopathologic evaluation are available for investigation of head and neck infections. Newer rapid molecular techniques with increased sensitivity and specificity are becoming available at many centers. Evaluation of specific causes in head and neck infections is complicated by the tendency for polymicrobial infections, difficulty in obtaining adequate specimens, and the presence of a diverse endogenous microflora at various mucosal sites that also can include true pathogens. These aspects of laboratory investigation for head and neck infections are reviewed in this article.

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Oral histoplasmosis after radiation therapy for laryngeal squamous cell carcinoma

Cited by 16 publications

References 15 publications

Head and Neck Histoplasmosis—A Nightmare for Clinicians and Pathologists! Experience at a Tertiary Referral Cancer Centre

Head and Neck Histoplasmosis—A Nightmare for Clinicians and Pathologists! Experience at a Tertiary Referral Cancer Centre

Disseminated Trichosporon inkin and Histoplasma capsulatum in a patient with newly diagnosed AIDS

Microbiologic Investigations for Head and Neck Infections

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