Oral histoplasmosis masquerading as an invasive carcinoma

Boutros, Hedy H; Winckle, Robert B van; Evans, Gerald A.; Wasan, S.

doi:10.1016/0278-2391(95)90135-3

Cited by 14 publications

(6 citation statements)

References 17 publications

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“…Historically, amphotericin B has been the drug of choice for systemic histoplasmosis (1–3, 8, 12, 16, 17, 32–37). The options have broadened considerably since the introduction of the azole compounds, ketoconazole and itraconazole (2, 6, 8, 38).…”

Section: Treatmentmentioning

confidence: 99%

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Oral histoplasmosis associated with HIV infection: a comparative study

Hernández

Blanc

Sambuelli

et al. 2004

J Oral Pathology Medicine

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OBJECTIVE: Histoplasmosis is a granulomatous fungal disease caused by Histoplasma capsulatum. The objective of the present paper was to describe the prevalence of oral histoplasmosis (OH) in two services from an endemic area in Argentina between 1991 and 2002 and to compare the clinicopathological profile of OH between HIV-positive and HIV-negative patients. METHODS: About 733 HIV+ (group A) and 14 260 patients (group B) were examined. Clinical diagnosis was confirmed by cytology, biopsy or culture. RESULTS: About 21 (3%) and 10 (0.07%) cases of OH were diagnosed in group A and B respectively. Most patients were male. A total of 90% of patients in group A were <45 years old whereas 70% of group B were more than 45 years old. Palate, gingiva and oropharynx were the most frequent locations. The importance of including histoplasmosis in the differential diagnosis of ulcerated oral lesions in immunocompromised patients was discussed.

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Section: Treatmentmentioning

confidence: 99%

“…The infecting agents are airborne spores from the mycelial form. It is usually found in warm, humid environments that contain bird and bat excreta (1–7). The most endemic areas for H. capsulatum are certain river valleys of the world between latitudes 45° north and 30° south of the equator (1, 4, 6–15).…”

Section: Introductionmentioning

confidence: 99%

Oral histoplasmosis associated with HIV infection: a comparative study

Hernández

Blanc

Sambuelli

et al. 2004

J Oral Pathology Medicine

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“…They are sometimes granulomatous, and the clinical appearance may resemble a malignant tumor. 40 The diagnosis is based on clinical appearance and histopathology and/or culture.…”

Section: Fungal Infectionsmentioning

confidence: 99%

Non‐Plaque‐Induced Gingival Lesions

Holmstrup

1999

Ann Periodontol

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The origin of gingival inflammation is occasionally different from that of routine plaque-associated gingivitis, and such non-plaque-associated types of gingivitis often present characteristic clinical features. Examples of such forms of gingivitis are specific bacterial, viral, and fungal infections. Specific bacterial infections of gingiva may be due to Neisseria gonorrhea, Treponema pallidum, streptococci, and other organisms. The most important viral infections of gingiva are herpes simplex virus type 1 and 2 and varicella-zoster virus. Fungal infections may be caused by several fungi, the most important of these being Candida species including C. albicans, C. glabrata, C. krusei, C. tropicalis, C. parapsilosis, and C. guillermondii. Gingival histoplasmosis is a granulomatous disease caused by the fungus Histoplasma capsulatum and, as for the other specific infections of gingiva, a confirmed diagnosis may require histopathologic examination and/or culture. Atypical gingivitis may also occur as gingival manifestations of dermatological diseases, the most relevant of these being lichen planus, pemphigoid, pemphigus vulgaris, erythema multiforme, and lupus erythematosus. Non-plaque induced gingival inflammation can be caused by allergic reactions to dental restorative materials, toothpastes, mouthwashes, and foods. In addition, gingival inflammation may result from toxic reactions, foreign body reactions, or mechanical and thermal trauma.

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“…Bats can become infected, and they transmit histoplasmosis through their droppings. 2,3,5,7 Histoplasmosis can be confirmed by histopathologic findings in cases in which abundant intracellular organisms are present. This disease has variable clinical findings, with pulmonary or systemic (disseminated) involvement.…”

mentioning

confidence: 97%

Pathology Quiz Case 2: Diagnosis

2011

Arch Otolaryngol Head Neck Surg

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Oral histoplasmosis masquerading as an invasive carcinoma

Cited by 14 publications

References 17 publications

Oral histoplasmosis associated with HIV infection: a comparative study

Oral histoplasmosis associated with HIV infection: a comparative study

Non‐Plaque‐Induced Gingival Lesions

Pathology Quiz Case 2: Diagnosis

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