Oral Human Papillomavirus and Human Herpesvirus-8 Infections Among Human Immunodeficiency Virus Type 1–Infected Men and Women in Italy

Mistro, Annarosa Del; Baboci, Lorena; Frayle, Helena; Trevisan, Rossana; Bergamo, Elisa; Lignitto, Laura; Sasset, Lolita; Cecchetto, Maria Grazia; Cattelan, Anna María; Calabrò, Maria Luisa

doi:10.1097/olq.0b013e31826ef2da

Cited by 22 publications

(15 citation statements)

References 28 publications

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“…Although the 19.5% prevalence for oral HPV infection was higher than previously reported for HIV-uninfected youth [Summersgill et al, 2001;Smith et al, 2004;Fakhry et al, 2006;D'Souza et al, 2007;Smith et al, 2007;Kreimer et al, 2010Kreimer et al, , 2011Beachler et al, 2012;Gillison et al, 2012;Kero et al, 2012;Pickard et al, 2012;Paolini et al, 2013], it was similar to that among youth at high-risk for sexually transmitted infections [Du et al, 2012;Schlecht et al, 2012]. The oral EBV prevalence (88.2%) in our study population was consistent with estimates previously reported in HIV-infected adults (42.1-90%) [Ammatuna et al, 2001;Miller et al, 2006], and healthy adults (90%) [Ikuta et al, 2000], and KSHV prevalence (11.8%) was also consistent with prior reports (11.6-57%) [Widmer et al, 2006;de Franca et al, 2011;Del Mistro et al, 2012].…”

Section: Discussionsupporting

confidence: 91%

Prevalence and risk factors for oral DNA tumor viruses in HIV-infected youth

Kahn

Rudy

et al. 2016

J. Med. Virol.

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Human papillomavirus (HPV), Epstein-Barr virus (EBV), and Kaposi sarcoma-associated herpes virus (KSHV) may promote oral cancers, especially among immunosuppressed individuals. The aims of this study were to examine whether demographic characteristics, medical history, sexual behaviors, substance use, CD4+ T-cell count, HIV viral load, and HPV vaccination were associated with HPV, EBV and KSHV infection and viral load. Multivariable modeling using logistic or linear regression examined associations between independent variables and infection or viral load, respectively. Among 272 HIV-infected 12–24 year-old youth, 19.5% were positive for oral HPV, 88.2% for EBV, and 11.8% for KSHV. In multivariable models, recent marijuana use (OR 1.97, 95% CI 1.02–3.82) and lower CD4+ T-cell count (< 350 vs. ≥ 350 cells/mm3: OR 1.92, 95% CI 1.003–3.69) were associated with HPV infection; lifetime tobacco use (estimated coefficient [EC] 1.55, standard error [SE] 0.53, p=.0052) with HPV viral load; recent tobacco use (OR 2.90, 95% CI 1.06–7.97) and higher HIV viral load (≥ 400 vs. < 400 copies/mL: OR 3.98, 95% CI 1.84–8.74) with EBV infection; Black vs. White race (EC 1.18, SE 0.37, p=.0023) and lower CD4+ T-cell count (EC 0.70, SE 0.28, p=.017) with EBV viral load, male vs. female gender (OR 10, 95% CI 1.32–100) with KSHV infection, and younger age at HIV diagnosis (1–14 vs. 18–20 years: EC 0.33, SE 0.16, p=.049; 15–17 vs. 18–20 years: EC 0.35, SE 0.13, p=.0099) with KSHV viral load. In conclusion, substance use and immunosuppression are associated with oral DNA tumor viruses in HIV-infected youth.

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Section: Discussionsupporting

confidence: 91%

Prevalence and risk factors for oral DNA tumor viruses in HIV-infected youth

Kahn

Rudy

et al. 2016

J. Med. Virol.

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“…Of notice, a high frequency of HHV‐8 infection was observed among MSM, compared to previous studies that reported a frequency ranging from 6% to 32.4% [Pierrotti et al, 2005; Ishak de et al, ; Batista et al, ]. This association is related to a greater number of sexual partners and a history of ISTDs [Mistro et al, ]. Although, it seems pertinent to observe that in sexual encounters it is difficult to exclude the possibility of behaviors that involve an oral route, such as oral sex which presented a borderline significance.…”

Section: Discussionmentioning

confidence: 80%

Prevalence of human herpesvirus 8 infection in people living with HIV/AIDS in Pernambuco, Brazil

et al. 2016

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This cross-sectional study aimed to estimate the seroprevalence and risk factors for Human herpesvirus 8 (HHV-8) infection among people living with HIV/AIDS in Recife, Pernambuco, Brazil. A total of 500 individuals were tested for antibodies against HHV-8 using the whole-virus ELISA. The prevalence of anti-HHV-8 was 28.6% and the frequency among 140 men who have sex with men (MSM) was 38.6%. In the univariate model, there were significant associations with male gender, detectable HIV load, travel abroad, bissexual, and homossexual orientation. The first HHV-8 seroepidemiologic study, in northeast Brazil, documents a highly prevalent HHV-8 infection among MSM living with HIV/AIDS. J. Med. Virol. 88:2016-2020, 2016. © 2016 Wiley Periodicals, Inc.

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“…However, data reported on heterosexual HIV-infected men are scarce [10,11]. The purpose of this study is to present data on the prevalence, evolution (clearance and incidence) and risk factors associated with type-specific HPV infections in the oral mucosa of MSM and heterosexual HIV-infected men.…”

Section: Regular and Careful Oral Inspection Is Neededmentioning

confidence: 98%

Oral human papillomavirus type-specific infection in HIV-infected men: a prospective cohort study among men who have sex with men and heterosexual men

Darwich

Cañadas

Videla

et al. 2014

Clinical Microbiology and Infection

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The natural history of type-specific oral infection of human papillomavirus (HPV) was assessed in a cohort of HIV-infected men (538 men who have sex with men (MSM); 195 heterosexuals). Risk factors associated with oral HPV infections were examined. The overall prevalence of HPV was 16%: HPV-16 was the most prevalent type (3.7% MSM; 7.8% heterosexuals). The prevalence of HPV-16 in heterosexuals was associated with CD4 nadir counts <200 cells/μL (ORadjusted = 3.0, 95% CI, 1.4-6.3). The overall incidence of HPV was similar between groups (11%), but the incidence of HPV-16 was higher in heterosexuals (ORadjusted = 3.2, 95% CI, 1.1-9.5). Not only MSM but also HIV-infected heterosexual men are at risk of HPV infection. Regular and careful oral inspection is needed.

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Oral Human Papillomavirus and Human Herpesvirus-8 Infections Among Human Immunodeficiency Virus Type 1–Infected Men and Women in Italy

Abstract: High prevalence of oral HPV and HHV8 infections was observed; MSM had the highest figures, despite better control of HIV infection.

Cited by 22 publications

References 28 publications

Prevalence and risk factors for oral DNA tumor viruses in HIV-infected youth

Prevalence and risk factors for oral DNA tumor viruses in HIV-infected youth

Prevalence of human herpesvirus 8 infection in people living with HIV/AIDS in Pernambuco, Brazil

Oral human papillomavirus type-specific infection in HIV-infected men: a prospective cohort study among men who have sex with men and heterosexual men

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