Oral Immunotherapy to Hake in 8 Pediatric Patients

Martorell-Calatayud, Cristina; Carnés, Jerónimo; Gómez, A.; Fernandez, Lilia; Zudaire, Luis Echeverría; Rodríguez, C. Santana; Galán, C. Gómez; Pérez, T Toral; Río, Pablo Rodríguez del; Aragonés, Antonio Martorell

doi:10.18176/jiaci.0372

Cited by 13 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the high consistency in the types of major allergens and fish among the six studies, they were combined into one overall study called Combination-6 for the quantitative analyses. In total, six clinical studies were included, with four utilizing processed meat from cod fish [ 46 , 47 , 48 ] and one each from salmon [ 49 ] and shrimp [ 50 ]. The processing methods in these studies included simple cooking in three studies [ 46 , 48 , 50 ], enzymatic hydrolysis of protease in one study [ 49 ], and lyophilization in one study [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…In total, six clinical studies were included, with four utilizing processed meat from cod fish [ 46 , 47 , 48 ] and one each from salmon [ 49 ] and shrimp [ 50 ]. The processing methods in these studies included simple cooking in three studies [ 46 , 48 , 50 ], enzymatic hydrolysis of protease in one study [ 49 ], and lyophilization in one study [ 47 ]. The Combination-6 study employed multiple processing methods, including cooking alone [ 8 , 42 ], dehydration and cooking [ 41 , 43 ], lyophilization [ 44 ], and dilution [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…( A ) Main meta-analysis; ( B ) subgroup analysis of seafood species (crustacea and fish); ( C ) subgroup analysis of different processing methods (simple cooking and others). IRR: incidence rate ratio [ 46 , 47 , 48 , 49 , 50 ].…”

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Intervention Efficacy of Slightly Processed Allergen/Meat in Oral Immunotherapy for Seafood Allergy: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis in Mouse Models and Clinical Patients

Han,

Wang,

Chen

et al. 2024

Nutrients

View full text Add to dashboard Cite

Background: Seafood allergy is a significant global health concern that greatly impacts a patient’s quality of life. The intervention efficacy of oral immunotherapy (OIT), an emerging intervention strategy, for seafood allergy remains controversial. This study aimed to perform a systematic review and meta-analysis to evaluate the efficacy of slightly processed allergen/meat from fish and crustacea in OIT, both in mouse models and clinical patients. Methods: A comprehensive literature search was performed in four mainstream databases and the EBSCOhost database to identify all relevant case–control and cohort studies. The aim was to elucidate the intervention efficacy, encompassing various processing methods and assessing the efficacy of multiple major allergens in OIT. Results: The meta-analysis included five case–control studies on crustacean allergens in mouse models and 11 cohort studies on meat from fish and crustacea in clinical patients for final quantitative assessments. In mouse models, crustacean allergen substantially decreased the anaphylactic score after OIT treatment (mean difference (MD) = −1.30, p < 0.01). Subgroup analyses with low-level heterogeneities provided more reliable results for crab species (MD = −0.63, p < 0.01, I2 = 0), arginine kinase allergen (MD = −0.83, p < 0.01, I2 = 0), and Maillard reaction processing method (MD = −0.65, p < 0.01, I2 = 29%), respectively. In clinical patients, the main meta-analysis showed that the slightly processed meat significantly increased the incidence rate of oral tolerance (OT, incidence rate ratio (IRR) = 2.90, p < 0.01). Subgroup analyses for fish meat (IRR = 2.79, p < 0.01) and a simple cooking treatment (IRR = 2.36, p = 0.01) also demonstrated a substantial increase in the incidence rate of OT. Sensitivity and meta-regression analyses successfully identified specific studies contributing to heterogeneity in mouse models and clinical patients, although these studies did not impact the overall significant pooled effects. Conclusions: This meta-analysis provides preliminary evidence for the high intervention efficacy of slightly processed allergen/meat from fish and crustacea in OIT, both in mouse models and clinical patients. The Maillard reaction and cooking processing methods may emerge as potentially effective approaches to treating allergen/meat in OIT for clinical patients, offering a promising and specific treatment strategy for seafood allergy. However, these findings should be interpreted cautiously, and further supporting evidence is necessary.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Intervention Efficacy of Slightly Processed Allergen/Meat in Oral Immunotherapy for Seafood Allergy: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis in Mouse Models and Clinical Patients

Han,

Wang,

Chen

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…However, several allergic reactions during OIT and the following observation period were documented both in adults and children, and they still did not reach a tolerated dose comparable to a typical fish portion. Recently, similar approaches were performed by D’Amelio in 2017 and Martore-Calatayud in 2019 by using hake instead in paediatric populations, with promising results [ 186 , 187 ].…”

Section: Managementmentioning

confidence: 99%

IgE-Mediated Fish Allergy in Children

et al. 2021

View full text Add to dashboard Cite

Fish allergy constitutes a severe problem worldwide. Its prevalence has been calculated as high as 7% in paediatric populations, and in many cases, it persists into adulthood with life-threatening signs and symptoms. The following review focuses on the epidemiology of Immunoglobulin E (IgE)-mediated fish allergy, its pathogenesis, clinical manifestations, and a thorough approach to diagnosis and management in the paediatric population. The traditional approach for managing fish allergy is avoidance and rescue medication for accidental exposures. Food avoidance poses many obstacles and is not easily maintained. In the specific case of fish, food is also not the only source of allergens; aerosolisation of fish proteins when cooking is a common source of highly allergenic parvalbumin, and elimination diets cannot prevent these contacts. Novel management approaches based on immunomodulation are a promising strategy for the future of these patients.

show abstract

“…Parvalbumin constitutes the main fish allergen, although enolase, aldolase, vitellogenin, and tropomyosin have also been described as allergens [ 103 ]. Recently, a Spanish group has reported the use of OIT to hake in several pediatric patients (aged 4–14 years) [ 76 ]. They proposed a novel and original protocol based on OIT with a known concentration of protein content and parvalbumin, administrating increasing quantities of lyophilized hake extract, up to reach the target dose of 225 mg.…”

Section: Allergen-specific Treatmentsmentioning

confidence: 99%

New Insights in Therapy for Food Allergy

Mayorga

Palomares

Cañas

et al. 2021

Foods

View full text Add to dashboard Cite

Food allergy is an increasing problem worldwide, with strict avoidance being classically the only available reliable treatment. The main objective of this review is to cover the latest information about the tools available for the diagnosis and treatment of food allergies. In recent years, many efforts have been made to better understand the humoral and cellular mechanisms involved in food allergy and to improve the strategies for diagnosis and treatment. This review illustrates IgE-mediated food hypersensitivity and provides a current description of the diagnostic strategies and advances in different treatments. Specific immunotherapy, including different routes of administration and new therapeutic approaches, such as hypoallergens and nanoparticles, are discussed in detail. Other treatments, such as biologics and microbiota, are also described. Therefore, we conclude that although important efforts have been made in improving therapies for food allergies, including innovative approaches mainly focusing on efficacy and safety, there is an urgent need to develop a set of basic and clinical results to help in the diagnosis and treatment of food allergies.

show abstract

Oral Immunotherapy to Hake in 8 Pediatric Patients

Cited by 13 publications

References 0 publications

Intervention Efficacy of Slightly Processed Allergen/Meat in Oral Immunotherapy for Seafood Allergy: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis in Mouse Models and Clinical Patients

Intervention Efficacy of Slightly Processed Allergen/Meat in Oral Immunotherapy for Seafood Allergy: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis in Mouse Models and Clinical Patients

IgE-Mediated Fish Allergy in Children

New Insights in Therapy for Food Allergy

Contact Info

Product

Resources

About