Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease

Abstract

These findings suggest that periodontitis is associated with endothelial dysfunction in patients with CAD through a decrease in nitric oxide bioavailability. Systemic inflammation may be, at least in part, a cause and predictor of progression of endothelial dysfunction.

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

“…The effects of periodontal intervention on serum IL-6 are not consistent. Some studies showed that periodontal therapy results in a decrease in IL-6 levels [38], although others found no significant differences post-therapy [39], In a recent study on coronary artery disease patients with periodontitis, periodontal therapy reduced serum concentrations of IL-6 at 6 months post-therapy [33]. Similar findings can be obtained in which periodontitis patients with coronary heart disease received mechanical periodontal therapy and control patients did not receive periodontal therapy.…”

“…Severe periodontitis can result in systemic inflammation characterized by elevated serum IL-6 [32]. A recent study reported that subjects with both coronary artery disease and periodontitis had significantly higher serum IL-6 concentrations compared with subjects with coronary artery disease who had no periodontitis [33]. TNF-α is involved in the initiation and development of coronary artery disease [34], and its levels increased in patients with periodontitis [35].…”

Periodontal Inflammation as Risk Factor for Pancreatic Diseases

“…Endothelial function has been reported to be significantly lower in patients with periodontitis than in control subjects. In addition, endothelial dysfunction in hypertensive patients with periodontitis is more severe compared to hypertensive patients without periodontitis (Higashi et al, 2009). Recently, endothelial function was evaluated in healthy and periodontitis patients with coronary artery disease (Higashi et al, 2008).…”

Periodontal associations in cardiovascular diseases: The latest evidence and understanding

“…15 Furthermore, patients diagnosed with CVD showed a considerable reduction of CRP from 2.7 AE 1.9 to 1.8 AE 0.9 mg/L (p < 0.05) 6 months postperiodontal therapy. 16 With the high number of patients affected by the two diseases, it becomes imperative for practitioners to be informed and aware of the increasing supporting evidence pointing to periodontal disease as a risk factor for ACVD. Therefore, some general clinical guidelines to be considered when treating these patients are as follows 3 :…”