Oral Lichen Planus: A review of clinical features, etiologies, and treatments

Elenbaas, Andrea; Enciso, Reyes; Al‐Eryani, Kamal

doi:10.1016/j.dentre.2021.100007

Cited by 29 publications

(30 citation statements)

References 123 publications

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“…Whilst spongiosis, leukocyte exocytosis, colloid body formation, postinflammatory hyper melanosis and saw-toothed rete ridges are introduced as less important histopathologic features of idiopathic OLP. 3,1,5,6 Although in the study of Kashyap et al, saw-toothed rete ridges are introduced as a major microscopic criterion.. 7 Consequently existing study intended to estimate& equate presence of saw tooth or pointed rete ridges in and between OLP and CLP.…”

Section: Introductionmentioning

confidence: 99%

A Histomorphology Comparison of Saw-Tooth Shaped Rete Ridge Between Oral and Cutaneous Lichen Planus

Saharkhiz

Aminzadeh

Yahyaabadi

2022

EDJ

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Lichen planus is chronic and comparatively collective inflammatory mucocutaneous disease. The histopathological features of oral lichen planus were described as comparable to those of cutaneous lichen planus(CLP). Among those saw-toothed rete ridges are introduced as less important histopathologic features of idiopathic OLP in contrast to CLP. Accordingly, existing study aimed to estimate existence of saw tooth rete ridges in OLP in comparison to CLP.; In this retrospective cross-sectional study, 56; E stained slides with clinical and histopathological diagnoses of OLP were randomly collected from the archive of the oral pathology laboratory. CLP cases were selected randomly from a private pathology laboratory and were evaluated for the presence of saw-toothed rete ridges. Collected data were evaluated using Chi-square; Fishers exact test in SPSS 24 at an error level of 0.05%. Chi-square test did not show a substantial difference between oral; cutaneous groups in terms of the shape of the rete ridges (p = 0.511). Outcomes of existing study showed that saw tooth rete ridge was seen in OLP similar to CLP. Future studies concerning clinical subtype and type of keratosis are recommended.

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Section: Introductionmentioning

confidence: 99%

A Histomorphology Comparison of Saw-Tooth Shaped Rete Ridge Between Oral and Cutaneous Lichen Planus

Saharkhiz

Aminzadeh

Yahyaabadi

2022

EDJ

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“…Oral lichen planus (OLP) is a chronic immune condition characterized by remission and flares. It is more common in females aged > 40 years and in non-Asian countries [ 1 2 ]. OLP has a worldwide prevalence of 1.01% and overall global prevalence of 0.89%.…”

Section: Introductionmentioning

confidence: 99%

“…OLP has a worldwide prevalence of 1.01% and overall global prevalence of 0.89%. The pathogenesis is postulated to be a chronic disease of the oral mucosa mediated by an antigen-specific mechanism that activates T-cells concomitant to a non-specific mechanism of mast cell degranulation [ 1 2 3 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of hyaluronic acid in the management of oral lichen planus: a systematic review and meta-analysis

Waingade

Medikeri

Gaikwad

2022

J Dent Anesth Pain Med

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Oral lichen planus (OLP) is a chronic inflammatory immune-mediated condition that has been identified as a potentially malignant oral disorder. Various therapies have been proposed for its management as alternative to corticosteroids. However, no definitive treatment has been identified that can result in complete remission or minimal recurrence. Hyaluronic acid has recently been used as an alternative therapy for the management of OLP. This study aimed to systematically review the effectiveness of Hyaluronic acid in the management of symptomatic OLP. Online electronic databases and manual searches were performed for randomized controlled trials (RCTs) published in English between January 2010 and April 2022. RCTs were identified that compared the efficacy of hyaluronic acid and other interventional therapies at baseline and during follow-up. The Cochrane Risk of Bias tool was used to assess the quality of the included studies. Visual analog scale (VAS) scores, Thongprasom sign scores, lesion size, degree of erythema, clinical severity, and disease severity were assessed both quantitatively and qualitatively. Seven studies were analyzed. Five studies reported a high risk of bias while the remaining two studies reported an unclear risk of bias. The overall quantitative assessment of size, symptoms, degree of erythema, and sign score in OLP lesions treated with HA was not statistically significant compared to that in the control group (P > 0.05). In addition, subgroup analysis comparing HA with placebo or corticosteroids did not yield statistically significant (P > 0.05) results. Qualitatively, both HA and tacrolimus resulted in an effective reduction in signs and symptoms. Clinical/disease severity index/scores were inconsistent. A high degree of heterogeneity was observed among the included studies. None of the included studies reported the side effects of HA. These findings suggest that corticosteroids, tacrolimus, placebo, and HA could be equally effective in OLP management. The clinical/disease severity index or score reduction cannot be determined with certainty. Thus, OLP can be treated with HA as an alternative therapy. Owing to limited clinical trials on HA, high heterogeneity, and high risk of bias in the included studies, definitive conclusions cannot be derived.

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“…"This decision was made primarily to reflect the reality of how readers are using journal content in the days of internet access, " -Laura Hirshbein, Editor in Chief [18]. The recently launched journals, for example Dentistry Review [19], are predominantly open access, printable online only publications.…”

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confidence: 99%

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J. Endod. Microsurg.

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Oral Lichen Planus: A review of clinical features, etiologies, and treatments

Cited by 29 publications

References 123 publications

A Histomorphology Comparison of Saw-Tooth Shaped Rete Ridge Between Oral and Cutaneous Lichen Planus

A Histomorphology Comparison of Saw-Tooth Shaped Rete Ridge Between Oral and Cutaneous Lichen Planus

Effectiveness of hyaluronic acid in the management of oral lichen planus: a systematic review and meta-analysis

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