Oral lichen planus and stress: An appraisal

Abstract

Introduction:Oral lichen planus (OLP) is a chronic inflammatory disease characterized by bilateral white striations or plaques on the buccal mucosa, tongue or gingiva that has a multifactorial etiology, where the psychogenic factors seem to play an important role.Purpose:The aim of this study was to determine the existing relation between the OLP and psychological alterations of the patient, such as stress, anxiety, and depression.Materials and Methods:Hospital anxiety and depression scale was applied for psychometric analysis.Results:The study indicates a definitive relationship between a stressful life event and onset and progression of OLP.Conclusion:Stress management and bereavement counseling should be a part of management protocol of OLP.

Declined hTERT expression of peripheral blood CD4+ T cells in oral lichen planus correlated with clinical parameter

“…Emerging evidences are suggesting that psychogenic factors such as anxiety, depression, and stress play important roles in the onset and progression of OLP . A high salivary cortisol level positively correlated anxiety was also showed in patients with OLP .…”

Clinical characteristics and analysis of familial oral lichen planus in eight Chinese families

“…Previous studies have suggested that OLP is a T cell-mediated autoimmune disease (3,12). Particular tendencies, such as smoking, alcohol consumption, drugs, eating spicy foods and bad hygiene, may exasperate symptoms of OLP (3,4,6). In addition, psychological disorders, such as anxiety, depression and stress, are associated with OLP (3,6,13).…”

“…(8). Histologically, OLP is characterized by a dense band-like lymphocytic infiltrate in the immediate sub-epithelial region with basal epithelial cell destruction (6).…”

“…OLP may occur in the buccal mucosa, tongue, gingiva, lip and palate, it may present in papular, reticular, plaque-like, atrophic, bullous and erosive forms (3)(4)(5), and frequently appears as a mixture of the forms (6). The lesions are typically multiple, symmetrical, bilateral and painless.…”

The Efficacy of Aloe vera Gel in Treatment of Oral Lichen Planus

“…Topical antimycotics (e.g., nystatin and amphotericin) may be prescribed when an infection is present. [3] Erosive OLP that is recalcitrant to topical corticosteroids may respond to topical tacrolimus. [4] Other potential therapies for recalcitrant OLP include hydroxychloroquine, dapsone, systemic corticosteroids, and topical and systemic retinoids.…”