Oral Lichen Planus

Torti, Dorothea C.; Jorizzo, Joseph L.; McCarty, Martha Ann

doi:10.1001/archderm.143.4.511

Cited by 60 publications

(14 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, a study did demonstrate that systemic absorption can occur with topical tacrolimus when treating OLP [66]. As with cutaneous LP, if patients are refractory to the above treatments, oral corticosteroids are also an option along with immunomodulatory agents such as azathioprine or methotrexate [67][68][69]. Given the risk of malignant transformation to oral squamous cell carcinoma, patients with OLP should be examined every 6 to 12 months with the option of biopsy if signs are suggestive of oral cancer.…”

Section: Lichen Planusmentioning

confidence: 99%

Cutaneous Manifestations of Viral Hepatitis

Ahmed

Said

2015

Curr Infect Dis Rep

View full text Add to dashboard Cite

There are several extrahepatic cutaneous manifestations associated with hepatitis B and hepatitis C virus infection. Serum sickness and polyarteritis nodosa are predominantly associated with hepatitis B infection, whereas mixed cryoglobulinemia associated vasculitis and porphyria cutanea tarda are more frequently seen in hepatitis C infection. The clinico-pathogenic associations of these skin conditions are not completely defined but appear to involve activation of the host immune system including the complement system. Management of the aforementioned cutaneous manifestations of viral hepatitis is often similar to that done in cases without viral hepatitis, with control of immune activation being a key strategy. In cases associated with hepatitis B and C, control of viral replication with specific antiviral therapy is also important and associated with improvement in most of the associated clinical manifestations.

show abstract

Section: Lichen Planusmentioning

confidence: 99%

Cutaneous Manifestations of Viral Hepatitis

Ahmed

Said

2015

Curr Infect Dis Rep

View full text Add to dashboard Cite

show abstract

“…1 , 8 Involvement of the oral mucosa is a common finding and can be the only sign of the disease. 2 , 6 , 7 The scalp, nails and genitalia can also be affected. Some studies have suggested malignant potential for OLP.…”

Section: Introductionmentioning

confidence: 99%

A Randomized Placebo-controlled Double Blind Clinical Trial of Quercetin for Treatment of Oral Lichen Planus

Amirchaghmaghi

Delavarian

Iranshahi

et al. 2015

J Dent Res Dent Clin Dent Prospects

View full text Add to dashboard Cite

Background and aims. Standard treatment of oral lichen planus (OLP) includes topical or systemic corticosteroids that have many adverse effects. A trend toward alternative natural or herbal drugs has attended recently. This study was conducted to evaluate the effect of quercetin in treatment of erosive-atrophic OLP.Materials and methods. Thirty patients participated in this randomized clinical trial from April 2010 to June 2010 (Trial Registration Number: NCT01375101). Patients were randomly allocated in two groups. Both groups received the standard treatment (dexamethasone mouthwash and nystatin suspension). Experimental group received oral 250 mg quercetin hydrate capsules (bid) and the control group received placebo capsules. The pain and severity of the lesions were recorded at the initial visit and the follow-ups. All recorded data were analyzed with chi-square, Mann-Whitney, t-test, Wilcoxon and Friedman tests using SPSS 11.5.Results. There were no significant differences between the two groups in severity of the lesions and pain in the follow-ups.According to the Friedman test, there was a significant reduction in pain (P = 0.01) and severity indices (P = 0.00) in the case group. These differences were not observed in the control group(P = 0.26,SI; and P = 0.86, PI). No adverse effect of quercetin was reported.Conclusion. According to the results, no significant therapeutic effect can be considered for quercetin in treatment of OLP.

show abstract

“…Lichen planus (LP) is an autoimmune disorder mediated by T lymphocytes that recognize self‐antigens on keratinocytes as foreign, leading to inflammation and keratinocyte cell death (1). Oral form of lichen planus (OLP) is a chronic inflammatory disease with unknown etiology, affecting approximately 2% of the population (2).…”

Section: Introductionmentioning

confidence: 99%

“…Six clinical forms of OLP have been described, but a simpler clinical classification consists of three types of lesions: reticular, atrophic, and erosive. Whereas reticular lesions are generally asymptomatic and often discovered incidentally during an oral examination, atrophic and erosive lesions frequently result in discomfort, causing patients to seek care (1, 3, 4).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The roles of matrix metalloproteinases‐2, ‐7, ‐10 and tissue inhibitor of metalloproteinase‐1 in the pathogenesis of oral lichen planus

Rubaci

Kazancioğlu

Olgaç

et al. 2012

J Oral Pathology Medicine

View full text Add to dashboard Cite

Along with the exposure of the role of MMPs activity on diseases characterized by the tissue destruction, several studies were conducted on the pharmacological control of MMPs activity. However, understanding of the biological functions of MMPs is very important for the development and implementation of MMP inhibitors in the treatment of diseases. According to the results of this study, we suggest that MMP-2, MMP-7, and TIMP-1 may be involved in the formation of OLP lesions. Further studies on MMPs may be useful for understanding and treating the diseases such as OLP.

show abstract

Oral Lichen Planus

Cited by 60 publications

References 18 publications

Cutaneous Manifestations of Viral Hepatitis

Cutaneous Manifestations of Viral Hepatitis

A Randomized Placebo-controlled Double Blind Clinical Trial of Quercetin for Treatment of Oral Lichen Planus

The roles of matrix metalloproteinases‐2, ‐7, ‐10 and tissue inhibitor of metalloproteinase‐1 in the pathogenesis of oral lichen planus

Contact Info

Product

Resources

About