Oral Magnesium Supplementation for the Prevention of Preeclampsia: a Meta-analysis or Randomized Controlled Trials

Yuan, Jing; Yu, Ying; Zhu, Tongyu; Lin, Xiaohong; Jing, Xincheng; Zhang, Juan

doi:10.1007/s12011-021-02976-9

Cited by 14 publications

(10 citation statements)

References 37 publications

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“…Jain et al examined blood samples from pregnant women with and without PE and found that a decrease in serum magnesium concentration during pregnancy may be a cause of PE 42 . A meta–analysis of magnesium intake and PE also showed that magnesium supplementation during pregnancy reduces the risk of PE (risk ratio [RR] = 0.54, 95%CI 0.59–0.98, P = 0.04) 43 . Our results for phosphorus 45 , iron 46 , manganese 47 and zinc 48 were similar to those obtained in previous studies.…”

Section: Discussionmentioning

confidence: 99%

The association between dietary mineral intake and the risk of preeclampsia in Chinese pregnant women: a matched case–control study

Liu,

Wang,

et al. 2023

Sci Rep

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Previous studies on the relationship between dietary minerals and preeclampsia (PE) have given inconsistent results. The aim of this study was to further clarify the relationship between dietary minerals intake and PE in Chinese pregnant women. In this study, 440 pairs of hospital–based preeclamptic and healthy women were matched 1:1. Dietary intake was obtained through a 78–item semi–quantitative food frequency questionnaire. Multivariate conditional logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were plotted to evaluate the dose–response relationship between dietary minerals intake and PE. This study found significant inverse associations for dietary intake of calcium, magnesium, phosphorus, iron, copper, manganese and zinc and the risk of PE in both univariate and multivariate models (all P- trend < 0.05). After adjusting for possible confounders, compared with the lowest quartile, the odds ratio of the highest quartile was 0.74 (95% CI 0.56–0.98) for calcium, 0.63 (95% CI 0.42–0.93) for magnesium, 0.45 (95% CI 0.31–0.65) for phosphorus, 0.44 (95% CI 0.30–0.65) for iron, 0.72 (95% CI 0.53–0.97) for copper, 0.66 (95% CI 0.48–0.91) for manganese and 0.38 (95% CI 0.25–0.57) for zinc. In addition, a reverse J–shaped relationship between dietary minerals intake and PE risk was observed (P–overall association < 0.05). In Chinese pregnant women, a higher intake of dietary minerals, including calcium, magnesium, phosphorus, copper, iron, manganese, and zinc was associated with a lower odds of PE.

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Section: Discussionmentioning

confidence: 99%

The association between dietary mineral intake and the risk of preeclampsia in Chinese pregnant women: a matched case–control study

Liu,

Wang,

et al. 2023

Sci Rep

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“…Mg supplementation may lower the odds of developing pre-eclampsia, based on moderate certainty of evidence. Pooled outcomes found a significant beneficial effect, though many of the individual Mg trials had non-significant results (53) . Based on high-quality evidence, a healthy maternal dietary pattern characterised by high intake of fruits, vegetables, whole-grain foods, fish and poultry as highlighted in Mediterranean and New Nordic diets was associated with 22 % reduced odds of developing pre-eclampsia (39) .…”

Section: Quality Of Evidencementioning

confidence: 94%

“…Serum vitamin B 12 was on average 15•24 pg/mL lower among women with pre-eclampsia when compared with those without (36) . Significantly lower Se concentrations among pre-eclamptic women compared with (12,32) OR 9•97 4•00, 24•9 23 1912 96 % High Serum Zn* (12,33) OR 0•35 0•17, 0•68 14 1091 88 % High Serum vitamin C* (12,34) OR 0•37 0•22, 0•61 29 2777 91 % Moderate Serum vitamin E* (12,34) OR 0 (31,37) RR 0•62 0•43, 0•91 12 1353 0 % High Vitamin D and Ca supplementation* (31,37) RR 0•49 0•31, 0•77 3 1120 0 % High Ca supplementation (52) RR 0•49 0•39, 0•61 30 20 445 59 % Moderate Mg supplementation* (53) RR 0•76 0•59, 0•98 7 2653 1 % Moderate Multiple micronutrient supplementation* (31) RR 0•40 0•27, 0•59 2 510 0 % Low Healthy maternal dietary pattern* (39) OR 0•78 0•70, 0•86 4 126 811 39 % High Ultra-processed foods dietary pattern (54) OR 1•28…”

Section: Possible Associationsmentioning

confidence: 99%

An evidence review and nutritional conceptual framework for pre-eclampsia prevention

et al. 2022

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Pre-eclampsia is a serious complication of pregnancy, and maternal nutritional factors may play protective roles or exacerbate risk. The tendency to focus on single nutrients as a risk factor obscures the complexity of possible interactions, which may be important given the complex nature of pre-eclampsia. An evidence review was conducted to compile definite, probable, possible and indirect nutritional determinants of pre-eclampsia to map a nutritional conceptual framework for pre-eclampsia prevention. Determinants of pre-eclampsia were first compiled through an initial consultation with experts. Secondly, an expanded literature review was conducted to confirm associations, elicit additional indicators and evaluate evidence. The strength of association was evaluated as definite RR<0.40 or ≥3.00, probable RR 0.40-0.69 or 1.50-2.99, possible RR 0.70-0.89 or 1.10-1.49 or not discernible RR 0.90-1.09. The quality of evidence was evaluated using GRADE. Twenty-five nutritional factors were reported in two umbrella reviews and 22 meta-analyses. Of these, 14 were significantly associated with pre-eclampsia incidence. Maternal vitamin D deficiency and higher serum iron emerged as definite nutritional risk factors for pre-eclampsia incidence across populations, while low serum zinc was a risk factor in Asia and Africa. Calcium and/or vitamin D supplementation were probable protective nutritional factors. Healthy maternal dietary patterns were possibly associated with lower risk of developing pre-eclampsia. Potential indirect pathways of maternal nutritional factors and pre-eclampsia may exist through obesity, maternal anaemia and gestational diabetes mellitus. Research gaps remain on the influence of household capacities and sociocultural, economic and political contexts, as well as interactions with medical conditions.

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“…For instance, recent evidence suggests that maternal supplementation of magnesium could be a way of alleviating the effects of oxidative stress. In fact, in maternal erythrocytes, magnesium modulates the rhythm of exchange of ions (especially SO4 2− ) through the protein AE1 (aka BAND3), and this leads putatively to a stabilization of the membrane structure, increasing their homeostasis and thus improving the resistance to oxidative stress-connected diseases [ 21 , 22 ], such as preeclampsia/eclampsia, diseases well known to be sensitive to magnesium supplementation [ 23 ].…”

Section: Reminders About Hypoxia Oxidative Stress and Placental Developmentmentioning

confidence: 99%

The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

2022

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Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to chemical, physical, and biological agents of OS, with potential pathological consequences. Here we shortly review the physiological and developmental functions of OS in the placenta, and present a series of environmental pollutants inducing placental oxidative stress, for which some insights regarding the underlying mechanisms have been proposed, leading to a recapitulation of the noxious effects of OS of environmental origin upon the human placenta.

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Oral Magnesium Supplementation for the Prevention of Preeclampsia: a Meta-analysis or Randomized Controlled Trials

Cited by 14 publications

References 37 publications

The association between dietary mineral intake and the risk of preeclampsia in Chinese pregnant women: a matched case–control study

The association between dietary mineral intake and the risk of preeclampsia in Chinese pregnant women: a matched case–control study

An evidence review and nutritional conceptual framework for pre-eclampsia prevention

The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

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