Oral malignant acanthosis nigricans associated with endometrial adenocarcinoma

Abstract

We report a 59-year-old patient with malignant acanthosis nigricans associated with metastasis of endometrial carcinoma. The patient presented papillomatosis lesions that appeared to be benign on multiple skins of body folds, particularly on lips. The lesions in lips and axilla had histological characteristic appearances of acanthosis nigricans, while the masses in abdomen and pelvis were metastasis endometrial adenocarcinoma. The article highlights the importance of biopsy and histopathological diagnosis in presumed benign lesions and the role of doctors in screening for body internal tumors.

Widespread Thickened, Verrucous, Hyperpigmented Plaques in a Woman With Weight Loss

“…Malignant AN has a more striking clinical presentation involving unusual locations such as the oral cavity, conjunctiva, and palms, in accordance with the severity of the disease. [2][3][4] It can occur with other cutaneous markers of internal malignant neoplasm, such as tripe palms and the Leser-Trélat sign. 2,3 It is mostly associated with gastric adenocarcinoma, followed by pulmonary carcinoma, hepatic carcinoma, esophageal carcinoma, and ovarian cancer, 2,3 arising either before or after detection of the tumor.…”

“…Acanthosis nigricans is a reactive skin pattern that presents as velvety to verrucous hyperpigmented plaques in body folds such as the axilla, neck, groin, and umbilicus. Malignant AN has a more striking clinical presentation involving unusual locations such as the oral cavity, conjunctiva, and palms, in accordance with the severity of the disease . It can occur with other cutaneous markers of internal malignant neoplasm, such as tripe palms and the Leser-Trélat sign .…”

Malignant acanthosis nigricans: a case report

“…There are two forms of acanthosis nigricans, benign and malignant, with the underlying disease mechanisms differing between the two types. Benign acanthosis nigricans can be caused by genetic and endocrine factors, obesity, and certain medications leading to elevated insulin levels [4]. Malignant acanthosis nigricans, on the other hand, is considered to represent a paraneoplastic syndrome co-occurring with cancers and is associated with internal malignancies, particularly gastric adenocarcinomas (55-61%) [5].…”

Image Gallery: Generalized mucosal and cutaneous papillomatosis, a unique sign of malignant acanthosis nigricans

“…Recently, a 41‐year‐old man presented with a rapid progression of verrucous lesions of the oral mucosa (a–d; haematoxylin–eosin stain, original magnification × 40) and eyelid conjunctivae (e), and typical skin symptoms (f–h) during postsurgery chemotherapy for gastric adenocarcinoma. Papillomatous mucosal lesions occur in 30–40% of patients with malignant AN and affect life quality dramatically …”