Oral manifestation of Crohn’s disease without concomitant gastrointestinal involvement

Salek, Hamid; Balouch, Amir; Sedghizadeh, Parish P.

doi:10.1007/s10266-013-0108-3

Cited by 8 publications

(17 citation statements)

References 6 publications

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“…Cobblestoning: The yugal mucosa exhibits normal color plaques separated by mild depressions or fissures, giving the appearance of cobblestones. In some circumstances, these lesions can difficult normal function, such as chewing ( 3 , 12 ).…”

Section: Resultsmentioning

confidence: 99%

Oral manifestations of gastrointestinal disorders

2017

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BackgroundA considerable number of gastrointestinal disorders (GIDs) of varied nature (inflammatory, infectious, genetic and other etiology) may produce alterations in the hard and soft oral tissues. Among these are Crohn’s disease, ulcerative colitis, celiac and gastroesophageal reflux disease.Material and MethodsArticle search was done using the National library of medicine (PubMed) database using different search terms and analyzed according to their importance.ResultsA large variety of GIDs can give rise to oral lesions, including: RAS like ulceration, mucosal tags, cobblestoning, mucogingivitis, labial and facial swelling, pyostomatitis vegetans, disgeusia and dental abnormalities, among others. Although in most cases the gastrointestinal signs and symptoms highlight in the clinical picture, a considerable percentage of these patients are affected by oral manifestations before the onset of gastrointestinal symptoms. This lesions can cause significant functional and aesthetics damages as well deteriorate the patient quality of life.ConclusionsAlthough the frequency of oral manifestations is variable across GIDs and in most cases is non-specific, these alterations may precede the underlying disease and therefore can facilitate an opportune diagnosis. Key words:Gastrointestinal disorders, oral lesions, oral mucosal disorders.

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Section: Resultsmentioning

confidence: 99%

Oral manifestations of gastrointestinal disorders

2017

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“…The use of the term 'orofacial granulomatosis' synonymously for oral Crohn's disease has generated some controversy. Some authors are of the opinion that the identical clinical presentation and histopathology of the two conditions suggests that they are a common process (67). They support this theory based on the fact that oral presentation may precede or succeed intestinal symptoms by several years, indicating that the lack of intestinal involvement at a particular point in time does not necessary mean the absence of it (17,68).…”

Section: Controversy Over Terminologymentioning

confidence: 99%

“…Others argue that the diagnosis of oral Crohn's disease can be made only in the presence or history of intestinal involvement (67). They base their argument on the notion that features consistent with orofacial granulomatosis can be seen in association with other autoimmune processes, such as cheilitis granulomatosa, sarcoidosis, and…”

Section: Controversy Over Terminologymentioning

confidence: 99%

The prevalence of oral lesions in patients with inflammatory bowel disease

Kiyani

Allen

McNamara

et al. 2014

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Inflammatory bowel disease is a group of idiopathic conditions characterized by chronic inflammation of the gastrointestinal tract, with Crohn's disease and ulcerative colitis being two common forms of this process. Extraintestinal manifestations of inflammatory bowel disease can be seen repeatedly in over 50% of patients, and can involve the skin, oral cavity, eyes, joints and the biliary tract. Oral lesions specific to Crohn's disease and ulcerative colitis often have very characteristic appearances. Some non-specific processes such as aphthous ulceration and candidiasis have also been linked to this condition. Despite detailed documentation of the presence and the nature of oral lesions in patients with inflammatory bowel disease, limited data is available regarding the prevalence. The objective of this study was to estimate the frequency of oral changes associated with inflammatory bowel disease in the U.S population in comparison to age-and sex-matched healthy controls. Methodology: One hundred patients with a prior diagnosis of either Crohn's disease or ulcerative colitis underwent periodic comprehensive oral examinations at the Wexner Medical Center gastroenterology clinic. Any abnormal oral mucosal changes noted during the exam were documented. A control population underwent a similar exam and documentation in the new patient screening clinic of The Ohio State University, College of Dentistry. iii Results: Out of 100 patients in the inflammatory bowel disease group, three were unavailable for follow-up. No lesions specific to either Crohn's disease or ulcerative colitis were noted in the remaining ninety-seven patients over the 12-month period. Two patients presented with candidiasis, 2 with aphthous ulcers and 2 with herpetic lesions. One patient in the control group also presented with aphthous ulcers. Conclusion: Based on these findings, the prevalence of oral lesions in this patient population with inflammatory bowel disease can be estimated to be less than 1%.

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“…Além disso, há uma variação de 150 tipos de genes que aumentam o risco da DII. Os fatores ambientais atuando em um indivíduo geneticamente suscetível favorecem o desenvolvimento da doença (11,12).…”

Section: Etiopatogêneseunclassified

O que o Cirurgião-Dentista Precisa Saber Sobre a Doença de Crohn?

Chagas¹,

Leão²,

Torres³

2021

RNO

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A doença de Crohn é descrita como uma doença inflamatória intestinal de alta complexidade, caracterizando-se por apresentar lesões e inflamações transmurais que podem acometer todo o trato gastrointestinal. A doença de Crohn pode apresentar manifestações bucais, tais como lesões na mucosa, alterações do fluxo salivar e envolvimento periodontal. Para este ar tigo de revisão, foi realizada uma busca de literatura nas bases de dados PubMed, Scielo e Academic Google, com espaço temporal de 2010 a 2020, utilizando palavras-chaves obtidas de acordo com o descritor em ciência da saúde. Foi encontrado que as lesões bucais estão presentes em cerca de 46,75% dos pacientes jovens e 22% dos pacientes idosos com doença de Crohn, podendo ser bastante incômodas, persistentes e de difícil tratamento. Apresentam-se com diversos aspectos clínicos como: ulcerações lineares ou aftosas, nodularidades da mucosa e aumento de volume labial. Essas lesões estão diretamente relacionadas com a doença, mas algumas lesões podem surgir de forma indireta, como complicação da doença de Crohn ou como efeitos adversos do tratamento. As manifestações bucais podem ser os primeiros sinais da doença de Crohn, logo, o reconhecimento de seus aspectos clínicos pode contribuir para um diagnóstico precoce. Cabe ao cirurgião-dentista reconhecer, diagnosticar e tratar, junto a uma equipe multiprofissional, as manifestações bucais da doença de Crohn, promovendo melhoras no quadro clínico dos pacientes.

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Oral manifestation of Crohn’s disease without concomitant gastrointestinal involvement

Cited by 8 publications

References 6 publications

Oral manifestations of gastrointestinal disorders

Oral manifestations of gastrointestinal disorders

The prevalence of oral lesions in patients with inflammatory bowel disease

O que o Cirurgião-Dentista Precisa Saber Sobre a Doença de Crohn?

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