Oral manifestations of systemic and cutaneous lupus erythematosus in a Venezuelan population

López-Labady, Jeaneth; Dorrego, Mariana Villarroel; González, Nieves; Perez, Ricardo; Henning, Magdalena Mata de

doi:10.1111/j.1600-0714.2007.00569.x

Cited by 47 publications

(71 citation statements)

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“…The oral mucosa can be affected in its systemic form (SLE) as well as in its cutaneous form (CLE) 10,11 as confirmed in the sample presented here, although publications about the frequency of these lesions are conflicting, depending on the stage of them and on the kind of treatment received 10,13 . Some authors suggest that the genal mucosa is involved in 9-45% of the cases of patients suffering from SLE and in 3-20% of cases of patients suffering from CLE 10,13 .…”

Section: Discussionmentioning

confidence: 59%

“…Preference for the jugal mucosa is due to the thickness of the epithelium as well as to its level of keratinization that allows histopathological alterations to reflect themselves clinically with greater facility than in other mucosas 6 . Lupus erythemathosus (LE) can develop in both sexes 3 and at any age although there is a greater predominance among women 10,11 . In this research there was a proportion of 1:4.…”

Section: Discussionmentioning

confidence: 99%

“…Lupus erythematosus (LE) is an autoimmune disease that, classically, can be subdivided into systemic lupus erythematosus (LES) and cutaneous lupus erythematosus(LEC) 10,11 . The involvement of the oral mucosa may occur in both forms 12 and the possibility of manifesting itself in a more agressive way recquires more attention and early diagnosis 3,12,13 .…”

Section: Introductionmentioning

confidence: 99%

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Avaliação clínica das lesões orais associadas a doenças dermatológicas

Gonçalves

Júnior²,

Cruz

2010

An. Bras. Dermatol.

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BACKGROUND: Dermatologic diseases are not only represented by lesions affecting the skin but also by manifestations that may involve the mucous membranes, including oral mucosa. OBJECTIVES: To evaluate the frequency of oral manifestations associated with dermatologic diseases considering location and clinical characteristics of the lesions found and also gender, age and race of patients. METHOD: It was an observational, cross-sectional study of patients who sought for treatment at the Dermatology Service of the University Hospital (Hospital Presidente Dutra-HUPD); UFMA, between October 2007 and October 2008 (n=88) . RESULTS: Age varied from 5 to 88 and there was predominance of female patients. 35% of the cases studied were diagnosed as lichen planus; 33% as lupus erythematosus; 24% as erythema multiforme; 7% as pemphigus vulgaris and 1% as pemphigoid group. Oral manifestations were more common among patients suffering from lichen pplanus (51%) and lupus erythematosus (20%). The most common clinical presentation found was reticular lichen planus located most predominantly in the buccal mucosa. CONCLUSIONS: It is essential that dentists know these pathologies to be able to diagnose them in an early stage of the disease and to direct patients to adequate treatment. Furthermore, intraoral examination should be included as a routine practice in dermatological services. Keywords: Dermatology; Diagnosis, oral; Oral manifestations Resumo: FUNDAMENTOS: As doenças dermatológicas não estão representadas apenas pelas lesões que afetam a pele, mas, também, por manifestações que podem envolver as mucosas, inclusive a mucosa oral. OBJETIVOS: Avaliar a frequência das manifestações orais em pacientes com doenças dermatológicas, considerando-se a localização e as características clínicas das lesões encontradas, o sexo, a idade e a raça dos acometidos. MÉTODOS: Estudo observacional, do tipo transversal, com pacientes que procuraram atendimento no Serviço de Dermatologia do Hospital Universitário Presidente Dutra (HUPD) da Universidade Federal do Maranhão (UFMA) entre outubro de 2007 e outubro de 2008 (n=88). RESULTADOS: A idade variou entre cinco e 88 anos, e o sexo feminino foi o mais atingido (2:1). Dos casos examinados, 35% eram de líquen plano, 33% de lúpus eritematoso, 24% de eritema multiforme, 7% de pênfi-go vulgar e 1% do grupo penfigoide. As lesões orais foram mais frequentes nos portadores de líquen plano (51%) e lúpus eritematoso (20%). O líquen plano reticular foi a forma clínica mais comum e a mucosa jugal, o sítio mais acometido. CONCLUSÕES: O conhecimento dessas patologias pelo cirurgião-dentista é de fundamental importância, cabendo-lhe uma parcela de responsabilidade pelo diagnóstico precoce e orientação para o tratamento adequado. Além disso, o exame intraoral deve ser incorporado como prática de rotina durante o atendimento dermatológico.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Avaliação clínica das lesões orais associadas a doenças dermatológicas

Gonçalves

Júnior²,

Cruz

2010

An. Bras. Dermatol.

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“…High prevalence of oral lesions in SLE is probably because of the fact that all tissues are potentially affected in this pole of the disease. 2 The oral lesions in acute LE are very common and appear erythematous stains of purple color with desquamative gingivitis, palatal erythema, and rarely ulcers. The bullae appear associated with bullous LE and affect the lip in a linear fashion.…”

Section: Discussionmentioning

confidence: 99%

“…Immunosuppressive treatments probably maintain patients free of mucosal alterations. 2 Dentists must enforce preventive dental care and monitor patients with SLE closely for head and neck infections because they are predisposed to severe infections. Thorough clinical examination is required to avoid overlooking infections.…”

Section: Discussionmentioning

confidence: 99%

Important Role of Caregiver in Management of Systemic Lupus Erythematosus on Patient with Mental Retardation

Ariani

Wimardhani²

2017

UIP HEATH MED

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Background: Systemic Lupus Erythematous (SLE) is a chronic autoimmune disease causing inflammation, pain and tissue damages. The systemic steroid and antimalarial agents are SLE's standard therapies. The challenges in achieving significant result include the extended period of treatment. Therefore, the patients' compliance to the dentist's treatment is crucial. There are some conditions where patient's compliance is difficult to obtain, for example in patients with mental retardation. To be able to receive information and treatment well, it takes an important role of caregiver to communicate and to assist the daily care.

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Mucosal lesions in cutaneous lupus erythematosus successfully treated with hydroxychloroquine

Kamaguchi

Iwata

Asaka

et al. 2019

Oral Science International

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| INTRODUC TI ONHydroxychloroquine (HCQ) is an antimalarial drug that has been used commonly in various countries to treat systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE), rheumatoid arthritis, and other inflammatory diseases. 1 HCQ was banned for a long time in Japan because of severe chloroquine retinopathy and was reapproved in 2015 as a first-line treatment for CLE. 2 CLE manifestations are wide-ranging, occasionally including mucous involvement of the lip, the tongue, and the buccal and nasal mucosa. 3 It is essential for dental practitioners to be familiar with CLE clinical manifestations and treatments, because CLE patients may present at dental clinics for their initial and main manifestations. However, in the field of dental medicine, no cases have addressed the effectiveness of HCQ for oral mucosal lesions in CLE. We present a case of CLE whose oral lesions were successfully treated with HCQ in close cooperation with dermatologists. | C A S E REP ORTA 76-year-old male was referred to the dental medicine and dermatology departments of our institution with a 12-month history of erosions on the lower lip and a 16-month history of erythematous macules on the skin. Physical examinations revealed multiple infiltrating erythematous plaques on the back, arms and palms, and painful erosions on the lower lip ( Figure 1A,B).Histopathological examinations of mucosa from the lower lip revealed hyperkeratosis, the thinning of the epithelium and the vacuolar degeneration of the basal cell layer accompanied by noticeable civatte bodies on the epidermis (Figure 2A). Perivascular infiltrates of lymphocytes and plasma cells associated with interstitial mucin deposition were observed in the dermis ( Figure 2B). Direct immunofluorescence showed linear deposition of C3 andIgM at the basement membrane zone ( Figure 3A). Multiple civatte bodies within the epidermis were clearly detected by fibrinogen staining ( Figure 3B). Systemic involvement suggestive of SLE, such as renal dysfunction, hemolytic anemia, and neurologic disease, was not detected. Considering all of the findings, we diagnosed the case as CLE with oral mucosal lesions. We administered a topical steroid and an oral rinse of azulene sodium salfanate, which proved ineffective. Therefore, HCQ (200 mg and 400 mg on alternate days) was introduced. One month later, the multiple rashes on the skin and erosions on the oral mucosa had resolved ( Figures 4A,B and 5). AbstractCutaneous lupus erythematosus (CLE) is a rare, potentially disfiguring, chronic autoimmune disease with extremely variable skin and mucosal membrane manifestations.Hydroxychloroquine (HCQ) is an antimalarial drug that has been used in various countries to treat autoimmune diseases including CLE. HCQ was banned for a long time in Japan because of severe chloroquine retinopathy and was reapproved as a first-line treatment for CLE in 2015. There are no case reports describing the effectiveness of HCQ for CLE with oral mucosal lesions in the dental field. We present a case of CLE w...

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Oral manifestations of systemic and cutaneous lupus erythematosus in a Venezuelan population

Abstract: These findings corroborated that ulcers are not the only manifestation of LE in the oral mucosa. Clinical and histological examinations are significant as immunoproteins are not always found on the oral sample.

Cited by 47 publications

References 22 publications

Avaliação clínica das lesões orais associadas a doenças dermatológicas

Avaliação clínica das lesões orais associadas a doenças dermatológicas

Important Role of Caregiver in Management of Systemic Lupus Erythematosus on Patient with Mental Retardation

Mucosal lesions in cutaneous lupus erythematosus successfully treated with hydroxychloroquine

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