Oral Microbiome and Oral Cancer

Perera, Manosha; Perera, Irosha; Tilakaratne, W. M.

doi:10.1002/9781119893035.ch7

Cited by 4 publications

(1 citation statement)

References 58 publications

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“…Oral cancer presents significant challenges stemming from late diagnosis, high metastatic potential, treatment complexities, and frequent recurrence. Dental pathogens interact with oral cancer through multifaceted mechanisms [8]. Firstly, chronic inflammation induced by pathogens creates a microenvironment conducive to tumor development.…”

Section: Introductionmentioning

confidence: 99%

Piperine-coated zinc oxide nanoparticles target biofilms and induce oral cancer apoptosis via BCl-2/BAX/P53 pathway

Shaik,

Kandaswamy,

Guru

et al. 2024

BMC Oral Health

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Background Dental pathogens play a crucial role in oral health issues, including tooth decay, gum disease, and oral infections, and recent research suggests a link between these pathogens and oral cancer initiation and progression. Innovative therapeutic approaches are needed due to antibiotic resistance concerns and treatment limitations. Methods We synthesized and analyzed piperine-coated zinc oxide nanoparticles (ZnO-PIP NPs) using UV spectroscopy, SEM, XRD, FTIR, and EDAX. Antioxidant and antimicrobial effectiveness were evaluated through DPPH, ABTS, and MIC assays, while the anticancer properties were assessed on KB oral squamous carcinoma cells. Results ZnO-PIP NPs exhibited significant antioxidant activity and a MIC of 50 µg/mL against dental pathogens, indicating strong antimicrobial properties. Interaction analysis revealed high binding affinity with dental pathogens. ZnO-PIP NPs showed dose-dependent anticancer activity on KB cells, upregulating apoptotic genes BCL2, BAX, and P53. Conclusions This approach offers a multifaceted solution to combatting both oral infections and cancer, showcasing their potential for significant advancement in oral healthcare. It is essential to acknowledge potential limitations and challenges associated with the use of ZnO NPs in clinical applications. These may include concerns regarding nanoparticle toxicity, biocompatibility, and long-term safety. Further research and rigorous testing are warranted to address these issues and ensure the safe and effective translation of ZnO-PIP NPs into clinical practice.

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Section: Introductionmentioning

confidence: 99%

Piperine-coated zinc oxide nanoparticles target biofilms and induce oral cancer apoptosis via BCl-2/BAX/P53 pathway

Shaik,

Kandaswamy,

Guru

et al. 2024

BMC Oral Health

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Impact of γ-herpes viruses’ status on established risk factor profile of oral squamous cell carcinoma tissues in a group of Sri Lankan male

Perera,

Perera

2023

Preprint

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Microbial dysbiosis is evident in oral squamous cell carcinoma (OSCC) tissues of a group of Sri Lankan male patients with oral risk habits

Perera,

Perera

2024

Preprint

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Our study identifies several potential periodontal pathogens, including Campylobacter concisus, Prevotella salivae, Prevotella loeschii, and Fusobacterium oral taxon 204. Additionally, Candida albicans is frequently associated with oral potentially malignant disorders (OPMDs) and oral cancers. Notably, we found a significant association between Candida etchellii and oral cancer for the first time. Furthermore, Capnocytophaga, Atopobium, and Candida were the most abundant microbial genera present in oral squamous cell carcinoma (OSCC) tissues.

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Oral Microbiome and Oral Cancer

Cited by 4 publications

References 58 publications

Piperine-coated zinc oxide nanoparticles target biofilms and induce oral cancer apoptosis via BCl-2/BAX/P53 pathway

Piperine-coated zinc oxide nanoparticles target biofilms and induce oral cancer apoptosis via BCl-2/BAX/P53 pathway

Impact of γ-herpes viruses’ status on established risk factor profile of oral squamous cell carcinoma tissues in a group of Sri Lankan male

Microbial dysbiosis is evident in oral squamous cell carcinoma (OSCC) tissues of a group of Sri Lankan male patients with oral risk habits

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