Oral microbiome findings challenge dentistry dogma

Campbell, Kristina

doi:10.1038/d41586-021-02920-w

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…These bacteria were found by Wirth et al [60] mainly in patients with gingivitis [60], which was in line with our investigation, where we found them with a greater log 2 in the BR group. Contrary to these findings, which indicate that S. salivarius has an anti-inflammatory action in the oral cavity [61], it has also been observed in dental caries [58]. Earlier findings showed that MUC7 attaches to S. gordonii but MUC5B does not, and S. sanguinis, S. oralis, and S. sobrinus can bind to MUC7 but not MUC5B [70].…”

Section: Discussionmentioning

confidence: 88%

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Changes in the Composition of Unstimulated and Stimulated Saliva Due to Chewing Sour Cherry Gum and a Toothbrush Change

Skopkó,

Homoki,

Fazekas

et al. 2024

Cells

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Background: Our previous studies demonstrated that sour cherry anthocyanins (AC) reduce the salivary count of Streptococcus mutans and inhibit salivary amylase activity within 30 minutes after chewing AC gum. AC gum and changing toothbrushes after scaling reduced the Gram-negative species in the unstimulated salivary microbiota. The present study examined the effect of AC gums on salivary factors, including changes in microbiome. Methods: The study was conducted over three weeks with two groups; young adults (18–30) and adults (30–45). Ten participants changed their toothbrushes, while the other 10 participants did not change after the control period. After scaling, all participants received three doses of AC gum daily. The salivary mRNA and protein levels of cytokines, mucins, melatonin, and the microbiota of unstimulated and stimulated saliva were determined by polymerase chain reaction, enzyme-linked immunosorbent assay, and 16S rRNA gene sequencing. Results: Significantly higher levels of tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), mucin5B (MUC5B), mucin7 (MUC7), and melatonin were detected in stimulated saliva. Correlation analysis of these factors with the microbiota showed positive correlations with the genera Lachnospiraceae, Eikenella, Saccharibacteria_(TM7), Streptococcus, Prevotella, and Haemophilus. Conclusions: AC chewing gum has a beneficial effect on the composition of the oral microbiome, and toothbrush replacement leads to changes in the levels of salivary pro-inflammatory cytokines.

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Section: Discussionmentioning

confidence: 88%

“…These results were in line with our study, where we found these bacteria with a higher abundance in the NBR group. Contradictory findings state that S. salivarius has an anti-inflammatory effect in the oral cavity [61], yet it also occurs in dental caries [58].…”

Section: Discussionmentioning

confidence: 99%

Changes in the Composition of Unstimulated and Stimulated Saliva Due to Chewing Sour Cherry Gum and a Toothbrush Change

Skopkó,

Homoki,

Fazekas

et al. 2024

Cells

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“…Streptococcus oralis has been recognized as a commensal organism in the oral cavity and an opportunistic pathogen capable of invading the bloodstream to cause bacteremia and infective endocarditis [ 38 ]. Streptococcus dentisani has been identified as a common inhabitant of the human oral cavity and possesses the ability to inhibit periodontal pathogens through a comprehensive probiotic action, characterized by antimicrobial, anti-adhesive, and anti-inflammatory effects [ 39 ]. Another pathogen found in the APXD group clustering is Streptococcus sanguinis , which is a Gram-positive, non-spore-forming, facultative anaerobic bloodstream pathogen that may cause infective endocarditis [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Metagenomic Characterization and Comparative Analysis of Removable Denture-Wearing and Non-Denture-Wearing Individuals in Healthy and Diseased Periodontal Conditions

Wong,

Hung,

Yip

et al. 2024

Microorganisms

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Removable denture wearers are at an increased risk of developing periodontal diseases due to biofilm deposition and microbial colonization on the denture surface. This study aimed to characterize and compare the metagenomic composition of saliva in denture wearers with different periodontal statuses. Twenty-four community-dwelling elders were recruited and grouped into denture wearers with active periodontitis (APD), non-denture wearers with active periodontitis (APXD), denture wearers with stable periodontal health conditions (SPCD), and non-denture wearers with stable periodontal health conditions (SPCXD). Saliva samples were collected and underwent Type IIB restriction-site-associated DNA for microbiome (2bRAD-M) metagenomic sequencing to characterize the species-resolved microbial composition. Alpha diversity analysis based on the Shannon index revealed no significant difference between groups. Beta diversity analysis using the Jaccard distance matrix was nearly significantly different between denture-wearing and non-denture-wearing groups (p = 0.075). Some respiratory pathogens, including Streptococcus agalactiae and Streptococcus pneumoniae, were detected as the top 30 species in saliva samples. Additionally, LEfSe analysis revealed a substantial presence of pathogenic bacteria in denture groups. In the cohort of saliva samples collected from community-dwelling elders, a remarkable abundance of certain opportunistic pathogens was detected in the microbial community.

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“…53 These oral microbes can escape the antibacterial defense of saliva and adapt to living in warm and humid environments, and are exposed to oxygen regularly. 54 Complex biological signal systems and interactions with the host regulate the microbes. Once the oral microbes is out of balance, the microbes will produce virulence factors and metabolites, leading to dental caries, periodontal diseases, etc.…”

Section: Microbial Environmentmentioning

confidence: 99%

Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Jia,

Zhang,

et al. 2024

Chem. Soc. Rev.

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Oral microbiome findings challenge dentistry dogma

Cited by 9 publications

References 7 publications

Changes in the Composition of Unstimulated and Stimulated Saliva Due to Chewing Sour Cherry Gum and a Toothbrush Change

Changes in the Composition of Unstimulated and Stimulated Saliva Due to Chewing Sour Cherry Gum and a Toothbrush Change

Metagenomic Characterization and Comparative Analysis of Removable Denture-Wearing and Non-Denture-Wearing Individuals in Healthy and Diseased Periodontal Conditions

Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

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