Oral microbiota: A new view of body health

Lu, Maoyang; Xuan, Songyu; Wang, Zhao

doi:10.1016/j.fshw.2018.12.001

Cited by 166 publications

(132 citation statements)

References 64 publications

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“…The roles of these microorganisms include digestion of food, resisting pathogens, maintaining homeostasis, and modulating the immune system, contributing in this way oral and general well-being. Despite this, they are also responsible for a variety of oral diseases [29,30].…”

Section: Oral and Intestinal Microbiota And Colorectal Cancermentioning

confidence: 99%

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

et al. 2020

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Colorectal cancer (CRC) is the third most diagnosed type of cancer worldwide. Dietary features play an important role in its development, and the involvement of human microbial communities in this pathology has also recently been recognized. Individuals with CRC display alterations in gut bacterial composition and a notably higher abundance of putative oral bacteria in colonic tumors. Many experimental studies and preclinical evidence propose that dietary polyphenols have a relevant role in CRC development and progression, mainly attributed to their immunomodulatory activities. Furthermore, polyphenols can modulate oral and gut microbiota, and in turn, intestinal microbes catabolize polyphenols to release metabolites that are often more active and better absorbed than the original phenolic compounds. The current study aimed to review and summarize current knowledge on the role of microbiota and the interactions between dietary polyphenols and microbiota in relation to CRC development. We have highlighted the mechanisms by which dietary polyphenols and/or their microbial metabolites exert their action on the pathogenesis and prevention of CRC as modulators of the composition and/or activity of oral and intestinal microbiota, including novel screening biomarkers and possible nutritional therapeutic implications.

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Section: Oral and Intestinal Microbiota And Colorectal Cancermentioning

confidence: 99%

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

et al. 2020

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“…The role of these oral microorganisms includes digestion of food, resistance against pathogens, maintenance of homeostasis, and the modulation of the immune system, contributing to oral and general well-being. However, they are also responsible for a variety of oral diseases [ 75 , 76 ]. Moreover, from an ecological perspective, it is important to emphasize that the oral microbiota is a reservoir that can transfer microbial strains to other parts of the body, such as the digestive system.…”

Section: Oral and Gut Microbiota In Alzheimer’s Diseasementioning

confidence: 99%

Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease

et al. 2020

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to the most common form of dementia in elderly people. Modifiable dietary and lifestyle factors could either accelerate or ameliorate the aging process and the risk of developing AD and other age-related morbidities. Emerging evidence also reports a potential link between oral and gut microbiota alterations and AD. Dietary polyphenols, in particular wine polyphenols, are a major diver of oral and gut microbiota composition and function. Consequently, wine polyphenols health effects, mediated as a function of the individual’s oral and gut microbiome are considered one of the recent greatest challenges in the field of neurodegenerative diseases as a promising strategy to prevent or slow down AD progression. This review highlights current knowledge on the link of oral and intestinal microbiome and the interaction between wine polyphenols and microbiota in the context of AD. Furthermore, the extent to which mechanisms bacteria and polyphenols and its microbial metabolites exert their action on communication pathways between the brain and the microbiota, as well as the impact of the molecular mediators to these interactions on AD patients, are described.

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“…15,16 Interaction of oral microbiomes with other microbiomes in various sites of human body, their implications in systemic pathologies (like esophageal cancer, colorectal cancer, pancreatic cancer, and inflammatory diseases such as atherosclerosis, pneumonia, heart diseases, and rheumatoid arthritis), and its relationship to diabetes and Alzheimer's disease highlight the importance of engineering in vitro models that mimic oral cavity situation for better disease diagnosis and treatment. [17][18][19][20] Two review articles have been published thus far that investigate in vitro and in vivo model systems' potential for studying the human microbiome, but not oral mucosa equivalents. Coenye and Nelis drew attention to the tools that could be used for understanding medically relevant biofilms, while Werlang et al investigated the requirement of mucin mimetics for in vitro culture systems and modu-lation of microbial community structure.…”

Section: Introductionmentioning

confidence: 99%

Three-DimensionalIn VitroOral Mucosa Models of Fungal and Bacterial Infections

Tabatabaei

Moharamzadeh

Tayebi

2020

Tissue Engineering Part B: Reviews

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Oral mucosa is the target tissue for many microorganisms involved in periodontitis and other infectious diseases affecting the oral cavity. Three-dimensional (3D) in vitro and ex vivo oral mucosa equivalents have been used for oral disease modeling and investigation of the mechanisms of oral bacterial and fungal infections. This review was conducted to analyze different studies using 3D oral mucosa models for the evaluation of the interactions of different microorganisms with oral mucosa. In this study, based on our inclusion criteria, 43 articles were selected and analyzed. Different types of 3D oral mucosa models of bacterial and fungal infections were discussed in terms of the biological system used, culture conditions, method of infection, and the biological endpoints assessed in each study. The critical analysis revealed some contradictory reports in this field of research in the literature. Challenges in recovering bacteria from oral mucosa models were further discussed, suggesting possible future directions in microbiomics, including the use of oral mucosa-on-a-chip. The potential use of these 3D tissue models for the evaluation of the effects of antiseptic agents on bacteria and oral mucosa was also addressed. This review concluded that there were many aspects that would require optimization and standardization with regard to using oral mucosal models for infection by microorganisms. Using new technologies-such as microfluidics and bioreactors-could help to reproduce some of the physiologically relevant conditions and further simulate the clinical situation.

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Oral microbiota: A new view of body health

Cited by 166 publications

References 64 publications

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease

Three-DimensionalIn VitroOral Mucosa Models of Fungal and Bacterial Infections

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