Abstract:The purpose of this study was to determine the clinico-pathological characteristics of so-called "denture fibroma" and to perform a review of literature. A comparative analysis was carried out to clarify the epidemiological characteristics of the lesion. A total of 142 cases (average age of 65.2 ± 11.1 years), predominantly female, with so-called "denture fibroma" was examined. The residual alveolar ridge in the posterior region (43.7 %) and in the anterior region (43.0 %) was affected with almost the same tendency. However, significant difference in the frequency between the maxilla and mandible was not observed. Macroscopically, majority of the lesions ranged from 1.1 -2.0 cm (52.5%) and 0.1-1.0 cm 3 (59.0%) in diameter. Histopathologically, myxoid degeneration (55.7%) was the most common feature and the presence of minor salivary gland in the connective tissue (26.2%) was observed simultaneously. In the review of literature, the incidence of denture fibroma ranged from 2.0 to 15.0% of the number of cases investigated. The number of cases among denture wearers ranged from 4.9 to 18.0% as reported. Regarding gender, the lesion affects both male and female with equal predominance. In other patients, the lesion was predominantly observed in elderly people with complete denture. Regarding the site of the lesion, the maxilla was reported to be the favored site. When the anterior and posterior regions were compared, many cases of denture fibroma arose in the anterior region overwhelmingly. A denture worn for more than 10 years was reported to be relevant in the development of so-called "denture fibroma".