2009
DOI: 10.1016/j.bjoms.2008.08.005
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Oral Mucosal irritation with incorrect use of alendronate

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Cited by 16 publications
(13 citation statements)
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“…Common side effects are oesophageal and gastric mucosal irritation [5]. Moreover, bisphosphonate intake represents a major risk factor for the development of bisphosphonate-induced osteonecrosis of the jaw and maxillofacial bone [6].…”
Section: Introductionmentioning
confidence: 99%
“…Common side effects are oesophageal and gastric mucosal irritation [5]. Moreover, bisphosphonate intake represents a major risk factor for the development of bisphosphonate-induced osteonecrosis of the jaw and maxillofacial bone [6].…”
Section: Introductionmentioning
confidence: 99%
“…The oral lesions were considered the result of prolonged BP remaining in the oral cavity, due to chewing of the tablet by the patient before swallowing, thus causing local tissue irritation. In our case, oral manifestations including labial ulceration, as well as gingival-osseous necrosis adjacent to the lower right canine are associated, for the first time, with intravenous use of ZA, and not oral aledronate, as in other cases [7][8][9][10][11][12].…”
Section: Discussionmentioning
confidence: 79%
“…Similarly, oral mucosal ulcerations of the tongue, the buccal mucosa, the floor of the mouth, or the lip are thought to be related to orally administrated BP (aledronate). These cases have been considered to arise because of incorrect, prolonged, local mucosal exposure or contact with the drug during oral (per os) administration [7][8][9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…Oesophageal and gastrointestinal ulceration are well‐established side effects of alendronate, but oral ulceration is less widely known . Many case reports attribute the development of oral ulceration with incorrect use of the medication, where the patient keeps the tablet in the mouth for a prolonged period instead of immediately swallowing it . However, reports have surfaced in which the adverse reaction has occurred when alendronate has been administered appropriately .…”
Section: Drug‐associated Mucosal Ulceration Mucositis and Bullous DImentioning
confidence: 99%
“…45 Many case reports attribute the development of oral ulceration with incorrect use of the medication, where the patient keeps the tablet in the mouth for a prolonged period instead of immediately swallowing it. 47 However, reports have surfaced in which the adverse reaction has occurred when alendronate has been administered appropriately. 46 While alendronate accounts for the majority of oral ulceration case reports, there have been cases involving the use of both etidronate and risedronate.…”
Section: Drug-associated Aphthous-like Ulcerationmentioning
confidence: 99%