Oral mucositis in patients with leukaemia following high-dose chemotherapy and autologous haematopoietic stem cells transplantation

Wojciechowicz, Jolanta; Kostyra, Magdalena; Kozińska, Justyna; Hus, Marek; Tomaszewski, Tomasz

doi:10.1016/j.achaem.2014.02.001

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…Also chemotherapy affects salivary glands function leading to temporary or permanent dysfunction that can result in saliva secretion reduction and inadequate composition. In addition chemotherapy affect microflora diversity and load; this imbalance responsible for opportunistic infections or the reactivation of latent viruses (Hey et al, 2009, Wojciechowicz et al, 2018. This result in the same line with that occured after 1 dose of 5-fluorouracil chemotherapy induced similar changes on sub mandibular salivary gland of rabbits and also reported that the severity and prevalence of pathological changes increased as chemotherapeutic doses increased (Özel et al, 2010, Merhan andEnas, 2020).…”

Section: Discussionmentioning

confidence: 68%

Protective role of royal jelly to alleviate side effects of chemotherapy on submandibular salivary glands of albino rats (Histological and Electron Microscopic Study)

Ahmad

Bakr

2021

Egyptian Dental Journal

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Chemotherapeutic agents often have severe tissue injury and cytotoxic effect. Royal jelly has beneficial biological effects, such as anti-inflammatory, antitumor, anti-allergic, and antioxidant activities on various cell types. Aim:The purpose of this study was to evaluate the protective role of royal jelly on cytarabine induced cytotoxicity on submandibular salivary glands of albino rats.Methods: 21 male albino rats weighing between 220 and 250 g. were divided equally into three groups. Group I (control group) normal without any medication. Group II (cytarabine group) at dose (100mg/kg/ I.P). Group III (cytarabine & Royal jelly group) was administrated royal jelly prior to cytarabine injection. After 2 weeks, the submandibular salivary glands were dissected out and prepared for histological and electron microscopic (TEM) examinations.Results: Light microscopic examination of cytarabine group revealed deformity of the secretory portions with numerous intracellular vacuoles, deeply stained atrophied nuclei. Dilated excretory ducts with degenerated epithelial lining. Some secretory cells were completely degenerated. While Royal jelly treated group revealed well defined serous acini and well formed striated ducts. TEM examination of cytarabine group revealed pyknotic nuclei with nuclear polymorphism. Swollen mitochondria and dilated RER. Striated duct has ill-defined cell boundaries and cytoplasmic vacuolizations. These changes were more improved with Royal jelly treated group group. Conclusion:Administration of Royal jelly produced a protective effect against cytotoxic changes induced by chemotherapy in rat submandibular salivary glands.

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Section: Discussionmentioning

confidence: 68%

Protective role of royal jelly to alleviate side effects of chemotherapy on submandibular salivary glands of albino rats (Histological and Electron Microscopic Study)

Ahmad

Bakr

2021

Egyptian Dental Journal

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“…In the present sample there were a great number of participants with leukemia, consequently, the conditioning regimens were mostly MA, which could explain the high incidence of OM (Eslami et al, 2016;Ramírez-amador et al, 2010;Small et al, 2007;Wojciechowicz et al, 2014).…”

Section: Discussionmentioning

confidence: 81%

Evaluación longitudinal de la mucositis oral en el trasplante de células madre hematopoyéticas: un estudio piloto

Mazur

Furquim

Nabhan

et al. 2019

OVital

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Objetivo: describir la incidencia y el puntaje de la mucositis oral (MO) y las morbilidades relacionadas en individuos sometidos a trasplante de células madre hematopoyéticas (TCMH) a lo largo del período de inmunosupresión. Métodos: Los sujetos con enfermedades onco / hematológicas, mayores de 14 años, sometidos a TCMH alogénico fueron evaluados diariamente por la presencia y clasificación de OM, nivel de dolor, disfagia, disgeusia y xerostomía. El examen comenzó dos días antes de la infusión de células madre hematopoyéticas y finalizó veinte días después. La OM se clasificó de acuerdo con la escala de la OMS y se utilizó la escala analógica visual (EVA) para medir el nivel de dolor. Resultados: se reclutaron 23 individuos, el 83% con enfermedades malignas y el 91% con OM. La mediana del grado máximo de OM fue 3 y el nivel máximo de dolor fue 9. Hubo una mediana de 11 días de uso de medicación opioide. Los sujetos que tuvieron el mayor número de días con dolor en la boca alcanzaron el grado máximo de OM y el mayor número de días y el uso de opioides. Conclusión: Hubo una alta incidencia y puntuaciones más altas de OM, pérdida de masa corporal y dolor en esta muestra.

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“…Of the remaining articles, 22 articles met the eligibility criteria. However, a total of 13 studies were excluded, including non‐randomized controlled studies (Aisa et al, 2005; Batlle et al, 2014; Baysal et al, 2021; Chen et al, 2017; Vokurka et al, 2011; Wojciechowicz et al, 2014), articles whose full text could not be accessed (Toro et al, 2014), studies without stem cell transplantation (Katranci et al, 2012; Papadeas et al, 2007; Sorensen et al, 2008), and articles with participants under the age of 18 (Kamsvåg et al, 2020; Kawaguchi et al, 2020; Magnusson et al, 2017). As a result, a total of nine articles were included in the systematic review (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Nurses play an important role in analysing the quality of life and strengths of patients undergoing stem cell transplantation, assessing their needs and implementing evidence‐based nursing interventions (Gori et al, 2007; Okada et al, 2016). In the management of oral mucositis, nurses' roles include following patients regularly, creating programs by obtaining information about oral mucositis management, discovering complementary therapies such as cryotherapy and reporting the effects of these treatment methods (Walladbegi et al, 2018; Wojciechowicz et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The effect of cryotherapy on oral mucositis management in patients undergoing stem cell transplantation: A systematic review of randomized controlled trials

Sezgi̇n

Bektaş

Özer

2022

Int J of Nursing Practice

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Aim This study aimed to investigate the effect of cryotherapy on oral mucositis management in patients undergoing stem cell transplantation. Background Oral mucositis is among the most common symptoms of stem cell transplantation. Cryotherapy may be an important treatment option in the oral mucositis process. Design A systematic review. Data Sources A literature review of studies published in the English language was conducted on Web of Science, Springer Link, Science Direct, Cochrane Library, PubMed, Scopus, ProQuest, Ovid, EBSCOhost/CINAHL Complete and MEDLINE databases until April 2022. The studies reviewed covered the years between 2006 and 2020. The data were summarized narratively. Review Methods This systematic review was organized in accordance with the Cochrane 2022 guidelines and reported using Preferred Reporting Items for Systematic Reviews and Meta‐Analyses. Results Nine studies were included in the systematic review. No significant publication bias was found in the main results. The results showed that the cryotherapy intervention had a positive effect on oral mucositis in patients undergoing stem cell transplantation. Conclusions In this systematic review of nine randomized controlled trials, the majority of the studies show that cryotherapy intervention can be an effective method for reducing oral mucositis in patients undergoing stem cell transplantation.

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Oral mucositis in patients with leukaemia following high-dose chemotherapy and autologous haematopoietic stem cells transplantation

Cited by 3 publications

References 11 publications

Protective role of royal jelly to alleviate side effects of chemotherapy on submandibular salivary glands of albino rats (Histological and Electron Microscopic Study)

Protective role of royal jelly to alleviate side effects of chemotherapy on submandibular salivary glands of albino rats (Histological and Electron Microscopic Study)

Evaluación longitudinal de la mucositis oral en el trasplante de células madre hematopoyéticas: un estudio piloto

The effect of cryotherapy on oral mucositis management in patients undergoing stem cell transplantation: A systematic review of randomized controlled trials

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