Oral nickel exposure may induce Type I hypersensitivity reaction in nickel-sensitized subjects

Büyüköztürk, Suna; Gelincik, Aslı; Ünal, Derya; Demirtürk, Mustafa; Çelik, Dolay Damla; Erden, Sacide; Çolakoğlu, Bahattin; Kuruca, Serap Erdem

doi:10.1016/j.intimp.2015.03.012

Cited by 17 publications

(7 citation statements)

References 30 publications

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“…Although contact urticaria to Ni have been described as a rare occurrence in literature, recently Salujia et al identified 11 patients with a contact urticarial to Ni and skin prick tests positive to Ni diluted at 2,5 % and 5% in aqueous solution, but patch tests negative, so suggesting immediate type reactions to Ni are yet undervalued and misdiagnosed [23]. Such an investigation confirmed a previous study of Büyüköztürk et al who have suggested the oral exposure to Ni may elicit an immediate type sensitization to the metal as they observed in a cohort of 69 patients [24].…”

Section: Foods Containing High Level Of Nisupporting

confidence: 62%

Nickel Hypersensitivity: A General Review on Clinical Aspects and Potential Co-Morbidities

GF¹,

Bonamonte²

2016

J Allergy Ther

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Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are able to induce an allergic reaction, nickel is the most frequent cause of metal allergy worldwide. The high prevalence of skin sensitization to that metal is the result of an ubiquitous exposure, being contained in different everyday things, such as detergents, cheap jewelry, cosmetics, coins, buttons, zippers, eyeglasses, buckles, clasps, inks, dental prosthesis and foods even. However, nickel is able to induce a wide range of morphological and clinical patterns, ranging from simple allergic contact dermatitis to systemic contact dermatitis and systemic nickel allergy syndrome. The latter seems to be promoted by nickel rich-foods or through endogenous route caused by metal implants which seem to elicit mainly in loco symptoms, sometimes with catastrophic consequences as aseptic bone necrosis following the implantation of hip prosthesis.

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Section: Foods Containing High Level Of Nisupporting

confidence: 62%

Nickel Hypersensitivity: A General Review on Clinical Aspects and Potential Co-Morbidities

GF¹,

Bonamonte²

2016

J Allergy Ther

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“…ACD and SNAS are complex conditions whose pathogenesis is yet to be fully elucidated. It has been suggested that an innate immune response, type I hypersensitivity and type IV immune reaction are responsible for cutaneous flare-ups [ 24 , 25 ], whereas circulating immune complexes (Type III reaction) and non-specific cytokine release may be in turn potentially responsible for the generalized symptoms of SNAS [ 26 ], leading altogether to enhanced inflammatory response. Unequivocal evidence produced in the past decades shows that low grade inflammation plays an important role in the pathogenesis of metabolic syndrome, where the activation of specific pathways leading to adipocyte dysfunction seems to lie at the bottom of the question[ 27 – 29 ].…”

Section: Discussionmentioning

confidence: 99%

Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals

et al. 2018

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BackgroundA lack of balance between energy intake and expenditure due to overeating or reduced physical activity does not seem to explain entirely the obesity epidemic we are facing, and further factors are therefore being evaluated. Nickel (Ni) is a ubiquitous heavy metal implied in several health conditions. Regarding this, the European Food Safety Authority has recently released an alert on the possible deleterious effects of dietary Ni on human health given the current levels of Ni dietary intake in some countries. Pre-clinical studies have also suggested its role as an endocrine disruptor and have linked its exposure to energy metabolism and glucose homeostasis dysregulation. Ni allergy is common in the general population, but preliminary data suggest it being even more widespread among overweight patients.ObjectivesThe aim of this study has been to evaluate the presence of Ni allergy and its association with the metabolic and endocrine profile in overweight and obese individuals.MethodsWe have evaluated 1128 consecutive overweight and obese outpatients. 784 were suspected of being allergic to Ni and 666 were assessed for it. Presence of Ni allergy and correlation with body mass index (BMI), body composition, metabolic parameters and hormonal levels were evaluated.ResultsWe report that Ni allergy is more frequent in presence of weight excess and is associated with worse metabolic parameters and impaired Growth Hormone secretion.ConclusionsWe confirm that Ni allergy is more common in obese patients, and we report for the first time its association with worse metabolic parameters and impaired function of the GH-IGF1 axis in human subjects.

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“…Büyükoztürk et al. (2015) studied patients with positive patch testing to nickel, by skin‐prick testing and measurement of interleukin (IL)‐10, IL‐4, IL‐5 and interferon (IFN)‐γ in supernatants of peripheral blood mononuclear cells stimulated by nickel during proliferation. Some patients were described as having reactions after placing dental devices in their mouth, others experienced symptoms after consuming foods with high levels of nickel, such as whole wheat, rye, cocoa, tea and green salads.…”

Section: Assessmentmentioning

confidence: 99%

“…At least part of the reason for a higher production of ROS in mouse testis compared to rat testis appears to be related to the much higher concentration of protamine 2 in mouse testes. The rat expresses only 2-5% of the level of protamine 2 compared to the mouse (Bunick et al, 1990;Belokopytova et al, 1993). Thus, some of the ROS production appears to be a result of the formation of a complex between nickel and the N terminus of protamine 2 in species that express this protein.…”

Section: Reproductive Toxicitymentioning

confidence: 99%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

101

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The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of postimplantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL 10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 lg/kg bw. Eczematous flare-up reactions in the skin elicited in nickel-sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest-observed-adverse-effect-level of 4.3 lg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel-sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.

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Oral nickel exposure may induce Type I hypersensitivity reaction in nickel-sensitized subjects

Cited by 17 publications

References 30 publications

Nickel Hypersensitivity: A General Review on Clinical Aspects and Potential Co-Morbidities

Nickel Hypersensitivity: A General Review on Clinical Aspects and Potential Co-Morbidities

Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals

Update of the risk assessment of nickel in food and drinking water

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