Oral Oncology and Reconstructive Surgery Fellowship Training Programs in India—A Trainee Perspective

Mohan, Sumedha; Popli, Gourav; Aggarwal, Kshitij

doi:10.1055/s-0041-1731582

Cited by 2 publications

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“…Clinically, surgery is prioritized for early-stage OC with better treatment effects ( D'Souza and Kumar 2020 ). However, chemotherapy is a palliative regimen, and its efficacy is not yet satisfactory for patients with advanced OC ( Mohan et al, 2021 ). Therefore, markers for early detection of oral malignancies and alternative treatment agents are necessary.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology Identifies Therapeutic Targets and the Mechanisms of Glutathione Action in Ferroptosis Occurring in Oral Cancer

Huang

Zhan

2022

Front. Pharmacol.

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Oral cancer (OC) is one of the most pernicious cancers with increasing incidence and mortality worldwide. Surgery is the primary approach for the treatment of early-stage OC, which reduces the quality of life of the patients. Therefore, there is an urgent need to discover novel treatments for OC. Targeting ferroptosis to induce cell death through the modulation of lipid oxidation has been used as a new approach to treat many cancers. Glutathione (GSH) is a coenzyme factor of GSH peroxidase 4, and it carries potential applicability in treating OC. By using network pharmacology and molecular docking followed by systematic bioinformatic analysis, we aimed to study GSH-targeting ferroptosis to treat OC. We identified 14 core molecular targets, namely, EGFR, PTGS2, HIF1A, VEGFA, TFRC, SLC2A1, CAV1, CDKN2A, SLC3A2, IFNG, NOX4, DDIT4, CA9, and DUSP1, involved in ferroptosis that were targeted by GSH for OC treatment. Functional characterization of these molecular targets showed their importance in the control of cell apoptosis, cell proliferation, and immune responses through various kinase activities such as the mitogen-activated protein kinase activity (e.g., ERK1 and ERK2 cascades) and modulation of TOR signaling (e.g., the HIF-1 signaling pathway). Molecular docking further revealed the direct binding of GSH with EGFR, PTGS2, and HIF1A proteins. These findings provide a novel insight into the targets of GSH in ferroptosis as well as possible molecular mechanisms involved, suggesting the possible use of GSH as a combined therapy for treating OC.

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Section: Introductionmentioning

confidence: 99%

Network Pharmacology Identifies Therapeutic Targets and the Mechanisms of Glutathione Action in Ferroptosis Occurring in Oral Cancer

Huang

Zhan

2022

Front. Pharmacol.

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“…This letter concerns the article in South Asian Journal of Cancer by Mohan et al 1 Although the argument for oral and maxillofacial surgery (OMFS) as a possible forerunner for head and neck surgical oncology training is largely acceptable, there are several riders to it, which I wish to point out. The deficiencies of a master's degree (MDS) in OMFS for cancer care include the following practical issues.…”

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confidence: 97%

SuperSpecialty-Level Training in Head and Neck Surgical Oncology

Varghese

2022

South Asian J Cancer

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Oral Oncology and Reconstructive Surgery Fellowship Training Programs in India—A Trainee Perspective

Cited by 2 publications

References 1 publication

Network Pharmacology Identifies Therapeutic Targets and the Mechanisms of Glutathione Action in Ferroptosis Occurring in Oral Cancer

Network Pharmacology Identifies Therapeutic Targets and the Mechanisms of Glutathione Action in Ferroptosis Occurring in Oral Cancer

SuperSpecialty-Level Training in Head and Neck Surgical Oncology

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