Oral phytonadione in neonatal hypoprothrombinemia

Shoshkes, M; Epplebaum, Aaron; Wilner, Milton

doi:10.1016/s0022-3476(59)80176-1

Cited by 7 publications

(1 citation statement)

References 18 publications

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“…PT was not significantly different between the investigated regimens, except for one paper by O'Connor et al 1986, reporting a significantly higher PT when no vit K prophylaxis was given compared to 2 mg oral or 1 mg IM once at birth [16]. In the other studies, PT values were within or above the adult range in the first days of life [22,24,25,30,35].…”

Section: Literature Reviewmentioning

confidence: 90%

Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant

et al. 2021

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Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB incidence. Simultaneously, information on practices was collected from Belgian pediatric and neonatal departments. Based on the review and these practices, a consensus was developed and voted on by all co-authors and heads of pediatric departments. Today, practices vary. In line with literature, the advised prophylactic regimen is 1 or 2 mg IM vitamin K once at birth. In the case of parental refusal, healthcare providers should inform parents of the slightly inferior alternative (2 mg oral vitamin K at birth, followed by 1 or 2 mg oral weekly for 3 months when breastfed). We recommend 1 mg IM in preterm <32 weeks, and the same alternative in the case of parental refusal. When IM is perceived impossible in preterm <32 weeks, 0.5 mg IV once is recommended, with a single additional IM 1 mg dose when IV lipids are discontinued. This recommendation is a step towards harmonizing vitamin K prophylaxis in all newborns.

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