Oral Rehydration: Toward a Real Solution

Guarino, Alfredo; Albano, Fabio; Guandalini, Stefano; ,

doi:10.1002/j.1536-4801.2001.tb07526.x

J. pediatr. gastroenterol. nutr.

2001

DOI: 10.1002/j.1536-4801.2001.tb07526.x

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Oral Rehydration: Toward a Real Solution

Alfredo Guarino,

Fabio Albano,

Stefano Guandalini

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Cited by 4 publications

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Reduced Osmolarity Oral Rehydration Solutions: New and Improved ORS?

Fuchs

2002

J. pediatr. gastroenterol. nutr.

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Reduced Osmolarity Oral Rehydration Solutions: New and Improved ORS?

Fuchs

2002

J. pediatr. gastroenterol. nutr.

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Oral Rehydration Solution Containing a Mixture of Non‐Digestible Carbohydrates in the Treatment of Acute Diarrhea: A Multicenter Randomized Placebo Controlled Study on Behalf of the ESPGHAN Working Group on Intestinal Infections

Hoekstra,

Szajewska,

Zikri

et al. 2004

J. pediatr. gastroenterol. nutr.

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Objective:A randomized, double‐blind, placebo‐controlled multicenter study to evaluate efficacy and safety of a mixture of non‐digestible carbohydrates (NDC) as an adjunct to oral rehydration therapy in treatment of acute infectious diarrhea in children with mild to moderate dehydration.Methods:144 boys aged 1 to 36 months with diarrhea defined as three or more watery stools per day for >1 day but <5 days with mild or moderate dehydration (World Health Organization criteria) were randomly assigned to receive hypotonic oral rehydration solution (ORS) (Na 60 mmol/L, glucose 111 mmol/L) with or without a mixture of NDC (soy polysaccharide 25%, α‐cellulose 9%, gum arabic 19%, fructooligosaccharides 18.5%, inulin 21.5%, resistant starch 7%).Results:Intention‐to‐treat analysis did not show significant differences in mean 48 hour stool volume (ESPGHAN‐ORS with NDC versus ESPGHAN‐ORS, 140 ± 124 g/kg versus 143 ± 114 g/kg; P = 0.41). Duration of diarrhea after randomization was similar in both groups (82 ± 39 hours versus 97 ± 76 hours, P = 0.24). There were no significant differences in the duration of hospital stay (111 ± 44 hours versus 126 ± 78 hours; P = 0.3). Unscheduled intravenous rehydration was similar in both groups (21.4% versus 16.2%, P = 0.42).Conclusion:In boys with acute non‐cholera diarrhea with mild to moderate dehydration a mixture of non‐digestible carbohydrates was ineffective as an adjunct to oral rehydration therapy.

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The Dawning of the “Zinc Era” in the Treatment of Pediatric Acute Gastroenteritis Worldwide?

Canani

Ruotolo

2006

J. pediatr. gastroenterol. nutr.

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Oral Rehydration: Toward a Real Solution

Cited by 4 publications

References 59 publications

Reduced Osmolarity Oral Rehydration Solutions: New and Improved ORS?

Reduced Osmolarity Oral Rehydration Solutions: New and Improved ORS?

Oral Rehydration Solution Containing a Mixture of Non‐Digestible Carbohydrates in the Treatment of Acute Diarrhea: A Multicenter Randomized Placebo Controlled Study on Behalf of the ESPGHAN Working Group on Intestinal Infections

The Dawning of the “Zinc Era” in the Treatment of Pediatric Acute Gastroenteritis Worldwide?

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