Oral submucous fibrosis and its dermatological relation

Ali, Fareedi Mukram; Patil, Ashok; Patil, Kishor; Prasant, M C

doi:10.4103/2229-5178.137772

Cited by 34 publications

(34 citation statements)

References 23 publications

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“…It becomes difficult to retract or evert the lips, which transform into an elliptical shape. [5] Etiology of OSMF is areca nut, chilies, and micronutrient deficiencies of iron, zinc, and essential vitamins. Demonstration of various autoantibodies has given a possible autoimmune basis to the disease.…”

Section: Discussionmentioning

confidence: 99%

Intralesional injections in oral submucous fibrosis - A series of case reports

Nagaraj¹,

Okade²,

Biswas³

et al. 2018

JMRPS

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Oral submucous fibrosis (OSMF) is a chronic insidious disease and is well-recognized as a premalignant condition. It is a collagen-related disorder associated with betel quid chewing and characterized by progressive hyalinization of the submucosa. It is a wellrecognized potentially malignant condition of the oral and oropharyngeal mucosa with initial inflammation followed by progressive fibrosis of the underlying connective tissues. The aim of this article is to report three cases of OSMF which was treated with intralesional injection of corticosteroids, hyaluronidase, and local anesthesia which showed remarkable improvement in the clinical symptoms.

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Section: Discussionmentioning

confidence: 99%

Intralesional injections in oral submucous fibrosis - A series of case reports

Nagaraj¹,

Okade²,

Biswas³

et al. 2018

JMRPS

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“…Oral submucous fibrosis (OSMF) was first reported in the mid-20th century and was found in the oral cavity, with symptoms of idiopathic partial epithelial atrophy and sclerosis (Ali, Patil, Patil, & Prasant, 2014). OSMF is a potentially malignant oral disorder with a high risk of malignant transformation.…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation therapy inhibits oral submucous fibrosis in mice

et al. 2020

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Objectives Oral submucous fibrosis (OSMF) is a chronic inflammatory disease and a potentially malignant oral disorder. However, the best therapeutic treatment for OSMF remains uncertain. Our previous study showed that photobiomodulation (PBM) therapy and forskolin could reduce arecoline‐induced fibrosis reactions via the cAMP pathway. The present study aimed to establish an animal model of areca nut extract (ANE)‐induced OSMF and to evaluate the therapeutic potential of PBM and forskolin for ANE‐induced OSMF. Subjects and methods The mice were divided into five groups. The buccal tissues were harvested for histomorphological analysis and immunoblotting. Results Our results showed that PBM significantly reduced the development of ANE‐induced OSMF, quantified by changes in submucosal layer thickness and collagen deposition. Additionally, PBM could extensively reduce the protein expression of the fibrotic marker genes alpha‐smooth muscle actin (α‐SMA) and connective tissue growth factor (CTGF) in buccal submucous lesions. However, forskolin treatment significantly decreased the protein expression of fibrotic marker genes but slightly decreased the observed histomorphological changes. Conclusions We established an ANE‐induced OSMF mouse model, which also provided a model for the development of a therapeutic treatment for OSMF. The anti‐fibrotic effects of PBM and forskolin may be useful for clinical interventions.

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“…It also reflects an autoimmune process in the oropharynx or a localized collagen disorder. 8 In advanced cases, trismus is the classical sequalae. Trismus cause problems in speech, oral hygiene, mastication and swallowing.…”

Section: Introductionmentioning

confidence: 99%

“…A cross-sectional study in Karachi which included 325 patients, showed a strong association among labial bands in the fauces and buccal bands. 8 In some cases, fibrosis affects the soft palate and uvula whereas gingiva is relatively spared. Blockage of Eustachian tube causes hearing impairment and oesophageal fibrosis causes swallowing difficulty.…”

Section: Introductionmentioning

confidence: 99%

Role of Pan Chewing in Oral Submucous Fibrosis - Our Experience

Anoop¹,

Bullar²,

Gupta³

et al. 2018

jebmh

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BACKGROUND Pan chewing causes Oral Sub-Mucous Fibrosis (OSMF) which is one of the major premalignant conditions of the oral cavity. It is seen mainly in South East Asia, Europe and North America. Malignant transformation to squamous cell carcinoma accounts for 2-3%. This risk is enhanced by the usage of pan and various tobacco products. MATERIALS AND METHODS We took up the present study in FH Medical College Etmadpur, Agra, from June 2017 to June 2018. 100 patients between the age group 21 years to 60 years where included in the study; who were attending outpatient department of ENT. RESULTS Most of them were having pan chewing as a habit. Pan chewing, tobacco chewing, and tobacco smoking were present in 16 patients. 78 patients were men. Most of the patients belonged to 30 to 39 age group. Conservative OPD treatment combined with surgical treatment gave good outcome in the treatment process. CONCLUSION We conclude that pan chewing and its various products has got strong association in the development of OSMF. Tobacco usage adds to the magnitude of the problem. Early diagnosis and treatment are important to prevent carcinomatous transformation.

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Oral submucous fibrosis and its dermatological relation

Cited by 34 publications

References 23 publications

Intralesional injections in oral submucous fibrosis - A series of case reports

Intralesional injections in oral submucous fibrosis - A series of case reports

Photobiomodulation therapy inhibits oral submucous fibrosis in mice

Role of Pan Chewing in Oral Submucous Fibrosis - Our Experience

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