Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats

Wang, Chengfang; Dan-qing, LI; Xue, Huadan; Hu, Bo

doi:10.1016/j.brainres.2009.10.034

Cited by 49 publications

(39 citation statements)

References 33 publications

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“…Oral administration of catalpol resulted in an increased expression of glucose transporter subtype 4 (GLUT4) in skeletal muscle of STZ-induced diabetic rats [16][17][18]. Catalpol can also ameliorate diabetic encephalopathy in rats [19]. In addition, catalpol has other pharmacological effects, such as neuron protection [20,21], against H 2 O 2 -induced apoptosis [22], and anti-inflammatory properties [23,24].…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis

Jiang

et al. 2014

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Catalpol, an iridoid glycoside, exists in the root of Radix Rehmanniae. Some studies have shown that catalpol has a remarkable hypoglycemic effect in the streptozotocininduced diabetic model, but the underlying mechanism for this effect has not been fully elucidated. Because mitochondrial dysfunction plays a vital role in the pathology of diabetes and because improving mitochondrial function may offer a new approach for the treatment of diabetes, this study was designed. Catalpol was orally administered together with metformin to high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mice daily for 4 weeks. Body weight (BW), fasting blood glucose (FBG) level, and glucose disposal (IPGTT) were measured during or after the treatment. The results showed a dose-dependent reduction of FBG level with no apparent changes in BW through four successive weeks of catalpol administration. Catalpol treatment substantially reduced serum total cholesterol and triglyceride levels in the diabetic mice. In addition, catalpol efficiently increased mitochondrial ATP production and reversed the decrease of mitochondrial membrane potential and mtDNA copy number in skeletal muscle tissue. Furthermore, catalpol (200 mg/kg) rescued mitochondrial ultrastructure in skeletal muscle, as detected with transmission electron microscopy. The relative mRNA level of peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) a was significantly decreased in muscle tissue of diabetic mice, while this effect was reversed by catalpol, resulting in a dose-dependent up-regulation. Taken together, we found that catalpol was capable of lowering FBG level via improving mitochondrial function in skeletal muscle of HFD/STZ-induced diabetic mice.

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Section: Introductionmentioning

confidence: 99%

Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis

Jiang

et al. 2014

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“…In the same way, a TeV-scale mass for the right-handed sneutrino can also be generated, which can serve as a good dark matter candidate [11]. In paper [12], we find the right handed neutrino can enhance the mass of SM Higgs several GeV.…”

Section: Introductionmentioning

confidence: 84%

Extending the MSSM with Singlet Higgs and Right Handed Neutrino for the Self-Interacting Dark Matter

Kang

Wang

2016

Commun. Theor. Phys.

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In order to meet the requirement of BBN, the right handed neutrino is added to the singlet Higgs sector in the GNMSSM. The spectrum and Feynman rules are calculated. the dark matter phenomenology is also studied. In case of λ ∼ 0, the singlet sector can give perfect explanation of relic abundance of dark matter and small cosmological structure simulations. The BBN constraints on the light mediator can be easily solved by decaying to the right handed neutrino. When the λ N is at the order of O(0.1), the mass of the mediator can be constrained to several MeV.

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“…O diabetes induz dano a neurônios, aumento de células apoptóticas no hipocampo, e disfunção cognitiva acompanhados de aumento acentuado do estresse oxidativo no cérebro 78 . O catalpol, por apresentar propriedades anti-inflamatórias e antioxidantes, foi testado por meio da suplementação oral em longo prazo em ratos diabéticos e mostrou capacidade para proteger os neurônios contra a neurodegeneração ao promover melhora da atividade de enzimas antioxidantes GPx, SOD, CAT e diminuir a concentração de malondialdeído (MDA) 78 .…”

Section: Antioxidantes E Encefalopatia Diabéticaunclassified

“…O catalpol, por apresentar propriedades anti-inflamatórias e antioxidantes, foi testado por meio da suplementação oral em longo prazo em ratos diabéticos e mostrou capacidade para proteger os neurônios contra a neurodegeneração ao promover melhora da atividade de enzimas antioxidantes GPx, SOD, CAT e diminuir a concentração de malondialdeído (MDA) 78 . Em modelo animal experimental de diabetes os níveis de MDA estão aumentados.…”

Section: Antioxidantes E Encefalopatia Diabéticaunclassified

Encefalopatia Diabética E Depressão: Dano Oxidativo No Cérebro

Louzada¹,

Vargas²

2015

cbr

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Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats

Cited by 49 publications

References 33 publications

Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis

Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis

Extending the MSSM with Singlet Higgs and Right Handed Neutrino for the Self-Interacting Dark Matter

Encefalopatia Diabética E Depressão: Dano Oxidativo No Cérebro

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