Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study

Kim, Jemin; Kim, Tae Hyun; Lee, Joohee; Choi, Se‐Young; Suk, Jangmi; Yang, Joo Hwan; Yang, Joon Sung; Kim, Jihee

doi:10.1089/jmf.2022.k.0097

Cited by 14 publications

(13 citation statements)

References 23 publications

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“…Low-molecular-weight collagen peptides are highly absorbable and favorably affect the quality and quantity of dermal component of the skin. 12,13 Several in vivo studies revealed the underlying mechanisms of oral collagen supplementation. In particular, this therapeutic approach reduces the expression and activation TA B L E 3 Skin wrinkling parameters of the per-protocol study population.…”

Section: Discussionmentioning

confidence: 99%

“…18,23 To date, the impact of collagen peptides on TEWL changes remains controversial. 11,13,16,18 The exact mechanism and effect of collagen peptides on the epidermal barrier via TEWL remain to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Previous clinical studies have employed doses of 0.5-10 g of collagen peptides, all demonstrating favorable effects on skin elasticity without notable adverse outcomes. 4,12,13 The translated values from in vivo studies ranged from 480 to 1620 mg/day, which enhanced skin dryness and wrinkle reduction. 4 However, the optimal dosage of collagen supplementation warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…It was suggested that these peptides can stimulate human fibroblasts to synthesize extracellular matrix molecules and strengthen the skin tissue 7 . In recent years, several clinical trials reported consistent data on oral collagen supplements with beneficial effects on the skin 11–13 . The aim of this study is to evaluate the clinical efficacy of oral low‐molecular‐weight collagen peptides supplementation for preventing wrinkles as well as promoting skin whitening via biophysical and skin imaging techniques.…”

Section: Introductionmentioning

confidence: 99%

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Low‐molecular‐weight collagen peptides supplement promotes a healthy skin: A randomized, double‐blinded, placebo‐controlled study

Seong,

Lee,

Lee

et al. 2023

J of Cosmetic Dermatology

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BackgroundOral collagen peptides supplementation was reported to improve skin integrity and counteract skin aging.AimsA randomized, double‐blinded, placebo‐controlled study was conducted to clinically evaluate the impact of low‐molecular‐weight collagen peptides on the human skin.Patients/MethodsHealthy adult participants (n = 100) were randomly assigned to receive a test product containing low‐molecular‐weight collagen peptides or a placebo. Parameters of skin wrinkles, elasticity, hydration, and whitening (melanin and erythema indexes) were measured at baseline and after 4, 8, and 12 weeks.ResultsCompared with the placebo group, the average skin roughness, maximum of all peak‐to‐valley values, maximum peak height of the wrinkle, and average maximum height of the wrinkle were significantly improved in the test group. Parameters of skin elasticity, including overall elasticity, net elasticity, and biological elasticity, were also significantly improved in the test group at Week 12 as compared with the placebo group. Moreover, skin hydration and whitening parameters changed more significantly in the test group than in the placebo group. None of the participants experienced adverse events related to the test product.ConclusionsTaken together, these findings suggest that low‐molecular‐weight collagen peptides supplementation can safely ehance human skin wrinkling, hydration, elasticity, and whitening properties.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Low‐molecular‐weight collagen peptides supplement promotes a healthy skin: A randomized, double‐blinded, placebo‐controlled study

Seong,

Lee,

Lee

et al. 2023

J of Cosmetic Dermatology

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“…RM-ANOVA and subsequent post hoc analysis revealed an overall significant improvement in the wrinkle scale during the study period as well as significant differences in the wrinkle scale between all follow-up appointments The unit of measurements and its interpretations were derived from previous studies. [6][7][8][9][10] Abbreviations: AU, artificial unit; R2, visco-elasticity in %; TEWL, transepidermal water loss.…”

Section: Efficacy Evaluationmentioning

confidence: 99%

The efficacy of intradermal hyaluronic acid filler as a skin quality booster: A prospective, single‐center, single‐arm pilot study

Lee,

Kim,

Lee

et al. 2023

J of Cosmetic Dermatology

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BackgroundThe use of “skin boosters” comprised of hyaluronic acid (HA)‐based fillers to improve skin quality has gained popularity recently, especially in individuals interested in skin rejuvenation.AimThis study aimed to evaluate the efficacy and safety of intradermal micropuncture injections of HA‐based gel filler combined with lidocaine (BYRYZN® SKINBOOSTER HA, ACROSS Co., Ltd., Gangwon‐do, Korea).Patients/MethodsA prospective, single‐arm, open‐label pilot study was conducted with study subjects who were aged between 30 and 60 years old and exhibited evidence of skin aging, such as wrinkles and loss of elasticity. They received three injections at 2‐week intervals and were followed up for a total of 12 weeks.ResultsTwenty subjects with a mean age of 54.1 years were included. The mean Lemperle wrinkle scale demonstrated a 40% decrease from 2.60 ± 0.60 at baseline to 1.55 ± 0.51 at week 8. The improvement rate was maintained at about 33% until week 12. The average maximum height of the wrinkle (Rz, μm), average skin roughness (Ra, μm), skin elasticity (R2, AU), facial curved length (mm), skin pore size (mm2), skin hydration (AU), TEWL (g/hm2), and skin glossiness (gloss value, AU) exhibited statistically significant improvements over time compared with the baseline measurements. No serious adverse effects or persistent adverse effects were reported, except for a transient subcutaneous nodule in one subject.ConclusionsThis study demonstrates that multiple microinjections of HA‐based gel filler for facial skin aging are safe and effective in improving facial skin quality.

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Efficacy and Safety of Type III Collagen Lyophilized Fibers Using Mid-to-Deep Dermal Facial Injections for the Correction of Dynamic Facial Wrinkles

Jia,

Qiu,

Zhang

et al. 2024

Aesth Plast Surg

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Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study

Cited by 14 publications

References 23 publications

Low‐molecular‐weight collagen peptides supplement promotes a healthy skin: A randomized, double‐blinded, placebo‐controlled study

Low‐molecular‐weight collagen peptides supplement promotes a healthy skin: A randomized, double‐blinded, placebo‐controlled study

The efficacy of intradermal hyaluronic acid filler as a skin quality booster: A prospective, single‐center, single‐arm pilot study

Efficacy and Safety of Type III Collagen Lyophilized Fibers Using Mid-to-Deep Dermal Facial Injections for the Correction of Dynamic Facial Wrinkles

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