Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study

Khajehdehi, Parviz; Pakfetrat, Maryam; Javidnia, Katayoun; Azad, F.; Malekmakan, Leila; Nasab, Mahshid Hashemi; Dehghanzadeh, Gholamreza

doi:10.3109/00365599.2011.585622

Cited by 180 publications

(155 citation statements)

References 24 publications

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“…In addition to the preventive effect of curcumin on insulin resistance, we demonstrated here that after the induction of obesity by HFD, short-term curcumin gavage still reversed glucose intolerance, clearly suggesting the therapeutic application of curcumin in the treatment of insulin resistance-related metabolic disorders. In light of its clinical usage, studies have been conducted and verified the effectiveness of curcumin in treating hyperglycemia-induced oxidative stress and related disorders, such as diabetic nephropathy [35,36] . In accordance, the present study provides a significant mechanism of Nrf2 activation by which curcumin can defend oxidative stress and mitochondrial redox imbalance and attenuate the abnormality of glucose metabolism in the condition of nutritional oversupply.…”

Section: Discussionmentioning

confidence: 99%

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

Wang²,

Gao³

et al. 2012

WJD

212

134

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AIM:To investigate the signaling mechanism of antioxidative action by curcumin and its impact on glucose disposal. METHODS:Male C57BL/6J mice were fed with either a normal diet (n = 10) or a high fat diet (HFD) (n = 20) to induce obesity and insulin resistance. After 16 wk, 10 HFD-fed mice were further treated with daily curcumin oral gavage at the dose of 50 mg/kg body weight (BW) (HFD + curcumin group). After 15 d of the curcumin supplementation, an intraperitoneal glucose tolerance test was performed. Fasting blood samples were also collected for insulin and glucose measurements. Insulin-sensitive tissues, including muscle, adipose tissue and the liver, were isolated for the assessments of malondialdehyde (MDA), reactive oxygen species (ROS) and nuclear factor erythroid-2-related factor-2 (Nrf2) signaling. RESULTS:We show here that in a HFD mouse model, short-term curcumin gavage attenuated glucose intolerance without affecting HFD-induced BW gain. Curcumin also attenuated HFD-induced elevations of MDA and ROS in the skeletal muscle, particularly in its mitochondrial fraction, but it had no such an effect in either adipose tissue or the liver of HFD-fed mice. Correspondingly, in skeletal muscle, the levels of total or nuclear content of Nrf2, as well as its downstream target, heme oxygenase-1, were reduced by HFD-feeding. Curcumin intervention dramatically reversed these defects in Nrf2 signaling. Further analysis of the relationship of oxidative stress with glucose level by a regression analysis showed a positive and significant correlation between the area under the curve of a glucose tolerance test with MDA levels either in muscle or muscular mitochondria. CONCLUSION:These findings suggest that the shortterm treatment of curcumin in HFD-fed mice effectively ameliorates muscular oxidative stress by activating Nrf2 function that is a novel mechanism for its effect in improving glucose intolerance. Key words: Oxidative stress; Insulin resistance; Glucose tolerance; Nuclear factor erythroid-2-related factor-2; Curcumin; Mitochondria

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Section: Discussionmentioning

confidence: 99%

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

Wang²,

Gao³

et al. 2012

WJD

212

134

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“…In addition, several other pro-inflammatory biomarkers are decreased by curcumin in human subjects (Hanai and Sugimoto, 2009;Khajehdehi et al, 2011;Koosirirat et al, 2010). In most of these studies, 150-500 mg of curcumin was sufficient to manifest a response.…”

Section: Suppression Of Tnf-a By Curcumin In Patientsmentioning

confidence: 99%

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Aggarwal

Gupta

Sung

2013

British J Pharmacology

343

239

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TNFs are major mediators of inflammation and inflammation-related diseases, hence, the United States Food and Drug Administration (FDA) has approved the use of blockers of the cytokine, TNF-a, for the treatment of osteoarthritis, inflammatory bowel disease, psoriasis and ankylosis. These drugs include the chimeric TNF antibody (infliximab), humanized TNF-a antibody (Humira) and soluble TNF receptor-II (Enbrel) and are associated with a total cumulative market value of more than $20 billion a year. As well as being expensive ($15 000-20 000 per person per year), these drugs have to be injected and have enough adverse effects to be given a black label warning by the FDA. In the current report, we describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable and highly safe in humans, yet can block TNF-a action and production in in vitro models, in animal models and in humans. In addition, we provide evidence for curcumin's activities against all of the diseases for which TNF blockers are currently being used. Mechanisms by which curcumin inhibits the production and the cell signalling pathways activated by this cytokine are also discussed. With health-care costs and safety being major issues today, this golden spice may help provide the solution. LINKED ARTICLESThis article is part of a themed section on Emerging Therapeutic Aspects in Oncology. To view the other articles in this section visit http://dx

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“…150 Orally administered curcumin has also been shown to down-151 modulate TNF-a expression in humans [35,36] (Table 3). Several 152 other proinflammatory biomarkers are also decreased by curcumin 153 in human subjects [37][38][39]. In most studies with human subjects, 154 150-500 mg of curcumin was sufficient to manifest a response, 155 and as little as 150 mg of curcumin has been shown to be effective 156 in reducing serum levels of pro-inflammatory cytokines [35].…”

Section: Introductionmentioning

confidence: 99%

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

Gupta

Tyagi

Deshmukh-Taskar

et al. 2014

Archives of Biochemistry and Biophysics

280

172

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Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study

Abstract: Short-term turmeric supplementation can attenuate proteinuria, TGF-β and IL-8 in patients with overt type 2 diabetic nephropathy and can be administered as a safe adjuvant therapy for these patients.

Cited by 180 publications

References 24 publications

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

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