Oral supplementation with l-glutamine alters gut microbiota of obese and overweight adults: A pilot study

Souza, Alessandra Zanin Zambom de; Zambom, Adriano Zanin; Abboud, Kahlile Youssef; Reis, Sabrina Karen; Tannihão, Fabiana; Guadagnini, Dioze; Saad, Mário J.A.; Prada, Patrícia O.

doi:10.1016/j.nut.2015.01.004

Cited by 71 publications

(40 citation statements)

References 32 publications

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“…had higher abundances in mice fed 0% melanoidin malts. However, there were significant decreases in Dorea and Oscillibacter throughout the study, which may be in line with a previous study showing the reduction of some genera belonging to Firmicutes, such as Dorea, after oral supplementation of glutamine [42]. A significant increase in Roseburia spp.…”

Section: Discussionsupporting

confidence: 91%

Gut Microbiota Modulation by Dietary Barley Malt Melanoidins

Aljahdali

Gadonna‐Widehem²,

Anton³

et al. 2020

Nutrients

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Melanoidins are the final Maillard reaction products (protein–carbohydrate complexes) produced in food by prolonged and intense heating. We assessed the impact of the consumption of melanoidins from barley malts on gut microbiota. Seventy-five mice were assigned into five groups, where the control group consumed a non-melanoidin malt diet, and other groups received melanoidin-rich malts in increments of 25% up to 100% melanoidin malts. Feces were sampled at days 0, 1, 2, 3, 7, 14, and 21 and the microbiota was determined using V4 bacterial 16S rRNA amplicon sequencing and short-chain fatty acids (SCFA) by gas chromatography. Increased melanoidins was found to result in significantly divergent gut microbiota profiles and supported sustained SCFA production. The relative abundance of Dorea, Oscillibacter, and Alisitpes were decreased, while Lactobacillus, Parasutterella, Akkermansia, Bifidobacterium, and Barnesiella increased. Bifidobacterium spp. and Akkermansia spp. were significantly increased in mice consuming the highest melanoidin amounts, suggesting remarkable prebiotic potential.

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Section: Discussionsupporting

confidence: 91%

Gut Microbiota Modulation by Dietary Barley Malt Melanoidins

Aljahdali

Gadonna‐Widehem²,

Anton³

et al. 2020

Nutrients

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“…In addition, the branch-chain amino acids (BCAAs) isoleucine and valine were negatively associated with the abundance of Christensenellaceae and positively associated with Blautia . Recent studies have shown that glutamine supplementation alters gut microbiota composition and improves glucose tolerance and obesity [29, 30]. In contrast, BCAAs and other hydrophobic amino acids, including alanine and the aromatic amino acids phenylalanine and tyrosine, have been shown to be elevated in individuals with metabolic disorders.…”

Section: Resultsmentioning

confidence: 99%

Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort

et al. 2017

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BackgroundThe gut microbiome is a complex and metabolically active community that directly influences host phenotypes. In this study, we profile gut microbiota using 16S rRNA gene sequencing in 531 well-phenotyped Finnish men from the Metabolic Syndrome In Men (METSIM) study.ResultsWe investigate gut microbiota relationships with a variety of factors that have an impact on the development of metabolic and cardiovascular traits. We identify novel associations between gut microbiota and fasting serum levels of a number of metabolites, including fatty acids, amino acids, lipids, and glucose. In particular, we detect associations with fasting plasma trimethylamine N-oxide (TMAO) levels, a gut microbiota-dependent metabolite associated with coronary artery disease and stroke. We further investigate the gut microbiota composition and microbiota–metabolite relationships in subjects with different body mass index and individuals with normal or altered oral glucose tolerance. Finally, we perform microbiota co-occurrence network analysis, which shows that certain metabolites strongly correlate with microbial community structure and that some of these correlations are specific for the pre-diabetic state.ConclusionsOur study identifies novel relationships between the composition of the gut microbiota and circulating metabolites and provides a resource for future studies to understand host–gut microbiota relationships.Electronic supplementary materialThe online version of this article (doi:10.1186/s13059-017-1194-2) contains supplementary material, which is available to authorized users.

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“…Next to butyric acid, glutamine is the major source for the epithelial cells and important for the recovery and preservation of the intestinal mucosa. It cannot be excluded that this may have an effect on the microbiota composition, as oral supplementation of glutamine has been shown to change the microbiota composition with a lower ratio of Firmicutes to Bacteroidetes (reduction of Dialister, Dorea, Pseudobutyrivibrio, and Veillonella) in obese subjects . Barley is also a very good source of polyphenols, a group of indigestible components associated to the fiber matrix and reported to reduce inflammatory responses, for example, through regulation of oxidative stress‐sensitive factors and increased expression of antioxidant proteins .…”

Section: Discussionmentioning

confidence: 99%