Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis

Lee, Hwee Chyen; Thng, Tien Guan Steven; Goh, Chee Leok

doi:10.1016/j.jaad.2016.03.001

Cited by 147 publications

(176 citation statements)

References 19 publications

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“…(12) Hwee Chyen Lee et al observed that relapse of melasma after stopping TXA 27.2% of those who improved and they suggested another course of TXA or other forms of therapy. (13) Our study results are comparable with the studies which showed beneficial effects in melasma treatment following oral TXA and topical TXA with microneedling procedure were observed. We observed significant improvement in both modalities of treatment, in which oral TXA shows higher improvement.…”

Section: Discussionsupporting

confidence: 90%

Comparative Clinical Study of Oral Tranexamic Acid and Topical Tranexamic Acid with Microneedling in the Management of Melasma

A¹

2017

jmscr

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Section: Discussionsupporting

confidence: 90%

Comparative Clinical Study of Oral Tranexamic Acid and Topical Tranexamic Acid with Microneedling in the Management of Melasma

A¹

2017

jmscr

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“…Melasma is known to have a high relapse rate (26). In one of the studies (14), oral TA alone resulted in a decrease in MASI by 1.89 at 3 months follow-up.…”

Section: Discussionmentioning

confidence: 97%

“…Management of melasma remains challenging and the search for a safe and effective therapy continues. The exact pathogenesis of melasma remains unclear, but genetic influences, ultraviolet (UV) exposure, and hormonal therapy have been reported as possible causative factors (5,8,26). Although epidermal hyperpigmentation is the key feature of melasma, increased dermal vascularity and expression of angiogenic factors also play a role and have remained important areas of interest in pigment research (4)(5)(6).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review

Kim¹,

Moon²,

Cho³

et al. 2017

Acta Derm Venerol

103

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“…After oral TA for 4 months, 89.7% of Korean patients had documented improvement, [17] and at a dosage of 250 mg twice daily for a therapeutic period of 6 months, TA was effective in 64.8% of Chinese patients. [3] Furthermore, a preliminary study of 2 tablets of compounded TA administered 3 times per day reported that improvement occurred in 85% of patients in 4 weeks, 97% in 8 and 12 weeks, and 100% in 16 weeks.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasma

Ma²,

Juliandri³

et al. 2017

Medicine

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To evaluate the efficacy of a functional microarray of microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women in China.Thirty female subjects with melasma were enrolled in this study. The left or right side of the face was chosen randomly to be pretreated with a functional microarray of MNs, followed by topical 0.5% TA solution once per week for 12 weeks. The other half-face was the control, treated with a sham device plus topical 0.5% TA solution. At baseline and at weeks 4, 8, and 12 of treatment, clinical (photographic) evaluations and parameters determined by Visia were recorded. At baseline and week 12, patient satisfaction scores and the biophysical parameters measured by Mexameter were also recorded. Side effects were evaluated at baseline and at the end of the 12 weeks.In total, 28 women (93.3%) completed the study. The brown spots’ scores measured by Visia were significantly lower on the combined therapy side than on the control side at 12 weeks after starting treatment; there was no significant difference between sides at 4 or 8 weeks. After 12 weeks, melanin index (MI) decreased significantly in both 2 groups, and the MI was significantly less on the combined side at week 12. Transepidermal water loss, roughness, skin hydration, skin elasticity, and erythema index showed no significant differences between 2 sides at baseline, 4, 8, and 12 weeks after treatment. Physicians’ evaluations of photographs showed better results at week 12 with combined therapy: >25% improvement was observed in the MNs plus TA side in 25 patients, and in the TA side in only 10 patients. Subjective satisfaction scores on both sides increased significantly. The participants were more satisfied with the results of the combined therapy side than the control side. No obvious adverse reactions were observed throughout the study.Combined therapy with a functional microarray of MNs and topical TA solution is a promising treatment for melasma.

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Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis

Cited by 147 publications

References 19 publications

Comparative Clinical Study of Oral Tranexamic Acid and Topical Tranexamic Acid with Microneedling in the Management of Melasma

Comparative Clinical Study of Oral Tranexamic Acid and Topical Tranexamic Acid with Microneedling in the Management of Melasma

Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review

Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasma

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