Oral Treatment of Ringworm With Griseofulvin

Williams, D. Innes; Marten, R H; Sárkány, I.

doi:10.1016/s0140-6736(58)92363-8

Cited by 160 publications

(42 citation statements)

References 5 publications

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“…Lauder and O'Sullivan (1958) described its use in the treatment of Trichopyhton 'l'errucosum infections in calves; it has been used in man, by Williams, et al (1958) agains't Microsporum audouini and Trichophyton rttbrum, and by Blank and Roth (1959), who reported the treatment of M. audouini, M. canis, T. rubrum, T. mentagrophytes, and T. tonsurans infection.…”

Section: B W Manktelowtmentioning

confidence: 99%

Thein vitroactivity of griseofulvin on some dermatophytes of veterinary interest

Manktelow¹

1960

New Zealand Veterinary Journal

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Section: B W Manktelowtmentioning

confidence: 99%

Thein vitroactivity of griseofulvin on some dermatophytes of veterinary interest

Manktelow¹

1960

New Zealand Veterinary Journal

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“…Griseofulvin was always given per os in the same doses used before by other investigators [3,4,7] and as recommended by Glaxo's ex perts. In children we have given 1 gram daily in sixteen cases and 0.5 gram daily in three (1,2 and 7 years old).…”

Section: Part I Therapeutic Trialsmentioning

confidence: 99%

Griseofulvin

Esteves¹,

Neves²

1959

Dermatology

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“…About twenty years later it was proved of value in the treatment of various fungous cutaneous infections in guinea-pig, cattle and man [13,26]. It was also reported that griseofulvin was effective in preventing, the inflammatory reactions often associated with mycoses [3,4,13].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory properties of griseofulvin

1977

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Anti-inflammatory activity of griseofulvin has been investigated in comparison with indomethacin and flufenamic acid. In vitro, griseofulvin has been proved the most effective of these agents in suppressing the contractions of smooth muscle preparations induced by a variety of proposed mediators of inflammation, i.e. histamine, 5-hydroxy-tryptamine, bradykinin and prostaglandin E2. In vivo, griseofulvin was unable to modify dextran oedema but suppressed carrageenin oedema, although its activity was poor when compared to that exhibited by indomethacin and flufenamic acid. When tested in rat pleurisy induced by dextran or homologous serum griseofulvin was able to prevent polymorph migration into the pleural space while mononuclears remained virtually unaffected. In contrast indomethacin and flufenamic acid mainly suppressed mononuclear migration while polymorphs resulted only slightly affected. Similar results have been exhibited by the drugs when tested on mononuclear turnover in pleural cavities from normal rats. Results are discussed in the light of the clinically established ability of griseofulvin to prevent cutaneous inflammatory reactions as well as of its effectiveness in the treatment of several polyarthritic syndromes.

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Oral Treatment of Ringworm With Griseofulvin

Cited by 160 publications

References 5 publications

Thein vitroactivity of griseofulvin on some dermatophytes of veterinary interest

Thein vitroactivity of griseofulvin on some dermatophytes of veterinary interest

Griseofulvin

Anti-inflammatory properties of griseofulvin

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