Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis

Stanojević, Stanislava; Blagojević, Veljko; Ćuruvija, Ivana; Veljović, Katarina; Bajić, Svetlana Soković; Kotur‐Stevuljević, Jelena; Bogdanović, Andrija; Petrović, Raisa; Vujnović, Ivana; Kovačević-Jovanović, Vesna

doi:10.1016/j.jff.2018.07.014

Cited by 4 publications

(4 citation statements)

References 74 publications

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“…Furthermore, L. rhamnosus may influence the composition through competition for nutrients and mucosal adhesion [29]. In this rize recent studies of L. rhamnosus in different IBD models, as shown i Damage score: Crude morphological scoring of the isolated colonic tissue [30]. Disease activity index (DAI) score: A composite score combining three conditions: percent weight loss, stool consistency, and stool bleeding [31].…”

Section: Introductionmentioning

confidence: 99%

The Potential Therapeutic Role of Lactobacillaceae rhamnosus for Treatment of Inflammatory Bowel Disease

Guo

Tian

et al. 2023

Foods

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Inflammatory bowel disease (IBD) is a heterogeneous group of diseases associated with chronic inflammation of the intestinal tract, and is highly prevalent worldwide. Although its origin is not yet fully understood, new evidence emphasizes that environmental factors, especially dietary factors and intestinal microbiota disorders are key triggers of IBD. Probiotics, such as Lactobacillaceae spp., play an essential role in human health as they exert beneficial effects on the composition of the human gastrointestinal microbial community and immune system. Probiotic-based therapies have been shown to be effective in alleviating IBD. Among these, Lactobacillaceae rhamnosus is one of the most widely used strains. L. rhamnosus is widely present in the intestines of healthy individuals; it regulates the intestinal immune system and reduces inflammation through a variety of mechanisms. The purpose of this study was to identify scientific evidence related to L. rhamnosus and IBD, review and summarize the results, and discuss the possible mechanisms of action as a starting point for future research on IBD treatment.

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Section: Introductionmentioning

confidence: 99%

The Potential Therapeutic Role of Lactobacillaceae rhamnosus for Treatment of Inflammatory Bowel Disease

Guo

Tian

et al. 2023

Foods

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“…This particular probiotic strain possesses immunomodulatory properties, as it increases IFN-γ /IL-4 ratio in lymph node cells when used as adjuvant for ocular mucosal immunization in mouse [29]. It also improves the health of adult rats with colitis when applied during early postnatal period, most probably by increasing microbiota diversity and intestinal growth during early life [30]. Given that variations in the efficacy of probiotics may be a result of inter-individual differences in probiotic colonization [31] and that data regarding the efficacy of probiotics as a result of differences in host innate immunity are lacking, we were interested to investigate whether i.p.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus rhamnosus Affects Rat Peritoneal Cavity Cell Response to Stimulation with Gut Microbiota: Focus on the Host Innate Immunity

et al. 2021

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Gut microbiota contribute to shaping the immune repertoire of the host, whereas probiotics may exert beneficial effects by modulating immune responses. Having in mind the differences in both the composition of gut microbiota and the immune response between rats of Albino Oxford (AO) and Dark Agouti (DA) rat strains, we investigated if intraperitoneal (i.p.) injection of live Lactobacillus rhamnosus (LB) may influence peritoneal cavity cell response to in vitro treatments with selected microbiota in the rat straindependent manner. Peritoneal cavity cells from AO and DA rats were lavaged two (d2) and seven days (d7) following i.p. injection with LB and tested for NO, urea, and H 2 O 2 release basally, or upon in vitro stimulation with autologous E.coli and Enterococcus spp. Whereas the single i.p. injection of LB nearly depleted resident macrophages and increased the proportion of small inflammatory macrophages and monocytes on d2 in both rat strains, greater proportion of MHCII hi CD163 − and CCR7 + cells and increased NO/diminished H 2 O 2 release in DA compared with AO rats suggest a more intense inflammatory priming by LB in this rat strain. Even though E.coli-and/or Enterococcus spp.-induced rise in H 2 O 2 release in vitro was abrogated by LB in cells from both rat strains, LB prevented microbiota-induced increase in NO/urea ratio only in cells from AO and augmented it in cells from DA rats. Thus, the immunomodulatory properties may not be constant for particular probiotic bacteria, but shaped by innate immunity of the host.

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“…There is currently no effective treatment available to prevent or cure food allergies [4]. However, according to numerous studies, breastfeeding protects the infant from developing allergic diseases, helps young infants' immune systems mature, and protects them from infections [4,29].…”

Section: Discussionmentioning

confidence: 99%

“…Stanojevic et al [29] revealed that early postnatal treatment with Lactobacillus rhamnosus LB64 appears to be effective in attenuating TNBS autoimmune encephalomyelitis. Similarly, early colonization with L. rhamnosus GG increased the richness and diversity of the colonic microbiota and promoted epithelial cell proliferation, differentiation, and mucosal IgA production in adults [38].…”

Section: Discussionmentioning

confidence: 99%

Probiotic Bacteria from Human Milk Can Alleviate Oral Bovine Casein Sensitization in Juvenile Wistar Rats

et al. 2023

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This study aims to see if probiotic bacteria from human milk could ameliorate oral cow’s milk sensitization. The probiotic potential of the SL42 strain isolated from the milk of a healthy young mother was first determined. Rats were then randomly gavaged with cow’s milk casein without an adjuvant or assigned to the control group. Each group was further subdivided into three groups, with each receiving only Limosilactobacillus reuteri DSM 17938, SL42, or a phosphate-buffered saline solution. Body weight, temperature, eosinophils, serum milk casein-specific IgE (CAS-IgE), histamine, and serum S100A8/A9 and inflammatory cytokine concentrations were measured. The animals were sacrificed after 59 days; histological sections were prepared, and the spleen or thymus weights, as well as the diversity of the gut microbiota, were measured. On days 1 and 59, SL42 abridged systemic allergic responses to casein by dropping histamine levels (25.7%), CAS-specific IgE levels (53.6%), eosinophil numbers (17%), S100A8/9 (18.7%), and cytokine concentrations (25.4–48.5%). Analyses of histological sections of the jejunum confirmed the protective effect of probiotic bacteria in the CAS-challenged groups. Lactic acid bacteria and Clostridia species were also increased in all probiotic-treated groups. These findings suggest that probiotics derived from human milk could be used to alleviate cow’s milk casein allergy.

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Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis

Cited by 4 publications

References 74 publications

The Potential Therapeutic Role of Lactobacillaceae rhamnosus for Treatment of Inflammatory Bowel Disease

The Potential Therapeutic Role of Lactobacillaceae rhamnosus for Treatment of Inflammatory Bowel Disease

Lactobacillus rhamnosus Affects Rat Peritoneal Cavity Cell Response to Stimulation with Gut Microbiota: Focus on the Host Innate Immunity

Probiotic Bacteria from Human Milk Can Alleviate Oral Bovine Casein Sensitization in Juvenile Wistar Rats

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