ORAL ULCERATIONS AS THE fiRST INDICATION OF FOLATE DEfiCIENCY SECONDARY TO METHOTREXATE THERAPY

Blanchard, Ariel; Kerpel, Stanley M.; Reich, R.; Freedman, Paul D.

doi:10.1016/j.oooo.2019.02.113

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Methotrexate (MTX) is a drug commonly used for the treatment of many forms of cancer by the way of inhibiting cancer cells from multiplying 1 . It was introduced into malignant disease treatment more than 50 years ago 2 however, its therapeutic effect is restricted by its low Blood brain barrier (BBB) permeability and poor brain targeting 3 .…”

Section: Introductionmentioning

confidence: 99%

“…It is considered as a basic chemotherapy drug for the treatment of brain tumors, especially leptomeningeal metastatic cancer and primary central nervous system lymphoma (PCNSL) 4 . MTX is also used to reduce inflammation in both psoriasis and rheumatoid arthritis 1 . It can enter the cells via two mechanisms active transport and passive diffusion, but active transport is the most dominant way 5 ,by the reduced folate carrier 6 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuro Protective Effects of Wheat Germ Oil on the Brain Inflammation Induced by Methotrexate in Mice

Hussein¹,

Radwan²

2019

Int Res J Pharm

View full text Add to dashboard Cite

The aim of this study is to evaluate the neurotoxicity of methotrexate (MTX) in mice, as well as the neuroprotective effects of wheat germ oil (WGO). One group of mice received corn oil orally for 10 days and a single dose of methotrexate (20 mg/kg) intraperitoneally on the 7th day. Another group was given both wheat germ oil orally for 10 days and methotrexate single dose (20 mg/kg) intraperitoneally on the 7th day. Our results suggest that the administration of MTX produced neurochemical and neurotoxic alterations in the brain causing severe damage including peripheral neuropathy and encephalopathy. It also led to brain tissue-damage by reactive oxygen species (ROS) generation, caused alteration in mitochondrial permeability and tissue injury as a response to the oxidative stress. WGO has neuroprotective action through scavenging the oxygen free radicals, decreasing lipid peroxidation and ameliorating the histopathological changes induced by MTX. WGO is recommended to patients undergoing MTX treatment.

show abstract

Section: Introductionmentioning

confidence: 99%