Oral ulcers in patients with advanced breast cancer receiving everolimus: a case series report on clinical presentation and management

Everolimus-associated stomatitis in a patient who had renal transplant

“…Previous case reports of mIAS have been reported in patients receiving high doses of everolimus for cancer treatment or liver transplants 15 16. Case series have described management of mIAS with Magic Mouthwash with the lesions resolving in 3–15 days in patients with renal cell carcinoma and breast cancer 13.…”

Risk of oral and gastrointestinal mucosal injury in patients with solid tumors treated with everolimus, temsirolimus or ridaforolimus: a comparative systematic review and meta-analysis

“…Stomatitis resolved within 1-2 weeks. Two of the four patients, who had interrupted everolimus, developed recurrent stomatitis following drug resumption, and everolimus was again discontinued and restarted after 2 weeks [21].…”

Overview and Management of Dermatologic Events Associated with Targeted Therapies for Medullary Thyroid Cancer

“…The lesions are very painful and may impair the ability to eat, drink, or speak (59,61). These aphthous-stomatitis-like lesions are treated with topical corticosteroids (e.g., clobetasol 0.05% cream) applied onto the lesions or dexamethasone solution swish and spit, taken three times daily with avoidance of eating or drinking for 30 minutes afterward (59,61).…”

“…The lesions are very painful and may impair the ability to eat, drink, or speak (59,61). These aphthous-stomatitis-like lesions are treated with topical corticosteroids (e.g., clobetasol 0.05% cream) applied onto the lesions or dexamethasone solution swish and spit, taken three times daily with avoidance of eating or drinking for 30 minutes afterward (59,61). In addition, topical lidocaine 2-4% jelly applied onto the lesions, or one tablespoon or less of lidocaine viscous swished around in the mouth and spat out (taken no more than every 3 h), will help mitigate the pain so that patients can eat or drink (38).…”

“…When xerotic skin is very dry and scaly, and for xerosis in the palms and soles, moisturizing creams or lotions containing salicylic acid 3-6%, respectively, or ammonium lactate 12%/lactic acid 12% (ammonium lactate topical) are recommended. Figure 7 (49,59,61,64,65) provides measures that may be helpful in preventing and managing xerosis and stomatitis.…”